Cell line · CVCL_8811
NB4-LR1
Cancer cell line, Homo sapiens. Acute promyelocytic leukemia with PML-RARA. 6 papers.
4 sourcescell-lines-2026-11-14-0.1.0
Cite this record
ConductScience Library. NB4-LR1. Cell lines, record CVCL_8811. Release cell-lines-2026-11-14-0.1.0, 14 Nov 2026. https://conductscience.org/library/cell-lines/CVCL_8811
On this page
Cell line
As Cellosaurus gives it.
- Name
- NB4-LR1
- Accession
- CVCL_8811
- RRID
- RRID:CVCL_8811
- Synonyms
- NB4-RAr, NB4-R1
- Species
- Homo sapiens (Human)
- Sex
- Female
- Age at sampling
- 23Y
- Category
- Cancer cell line
- Diseases
- Acute promyelocytic leukemia with PML-RARA (NCIt C3182); Acute promyelocytic leukemia (ORDO Orphanet_520)
- Derived from
- Bone marrow (in situ)
- Parent
- NB4 (CVCL_0005)
- Entry created
- 2012-06-06
- Entry updated
- 2025-08-14
Source Cellosaurus
Problems0
Cellosaurus records no problem for this cell line.
None in this release.
Papers6
| Paper | Journal | Year | How we know | Retracted | Source |
|---|---|---|---|---|---|
| Novel noscapine derivative induces AML differentiation by dual-engaging DHODH and mitochondrial lipids to trigger a metabolic-epigenetic-transcriptional cascade. | Acta Pharm Sin B | 2026 | Its Methods give the RRID and name the line | PubMed | |
| Choosing the Right Cell Line for Acute Myeloid Leukemia (AML) Research. | Int J Mol Sci | 2023 | Cellosaurus cites it | PubMed | |
| Maturation sensitive and resistant t(15;17) NB4 cell lines as tools for APL physiopathology: nomenclature of cells and repertory of their known genetic alterations and phenotypes. | Oncogene | 2001 | Cellosaurus cites it | PubMed | |
Distinct apoptotic responses in maturation sensitive and resistant t(15;17) acute promyelocytic leukemia NB4 cells. 9-cis retinoic acid induces apoptosis independent of maturation and Bcl-2 expression. | Leukemia | 1995 | Cellosaurus cites it | PubMed | |
| Two distinctly regulated events, priming and triggering, during retinoid-induced maturation and resistance of NB4 promyelocytic leukemia cell line. | Proc Natl Acad Sci U S A | 1994 | Cellosaurus cites it | PubMed | |
| A retinoid acid 'resistant' t(15;17) acute promyelocytic leukemia cell line: isolation, morphological, immunological, and molecular features. | Leukemia | 1992 | Cellosaurus cites it | PubMed |
Relatives2
| Relation | Cell line | Accession | Problem | Source |
|---|---|---|---|---|
| Parent | NB4 | CVCL_0005 | Cell lines | |
| Derived from it | NB4-LR2 | CVCL_U081 | Cell lines |
Cell banks0
None in this release.
Data dates
The date of each source this release read.
Sources 4
- CellosaurusCC BY 4.0, with credit to Cellosaurus (SIB)
- PubMed Central's articlesTitles shown only for CC0, CC BY and public domain articles
- NLM's PMC Article DatasetsCourtesy of NLM, which does not endorse this database
- PubMedNLM's terms
Each source's terms
- CellosaurusCC BY 4.0. Cellosaurus's README: "we have chosen to apply the Creative Commons Attribution 4.0 International (CC BY 4.0) license to Cellosaurus (https://creativecommons.org/licenses/by/4.0/). This means that you are free to copy and redistribute Cellosaurus in any medium or format. You can remix, transform, and build upon Cellosaurus for any purpose, even commercially. You must give appropriate credit, provide a link to the license, and indicate if changes were made." Copyright (c) CALIPHO group, SIB Swiss Institute of Bioinformatics. Read on 14 Nov 2026 at https://ftp.expasy.org/databases/cellosaurus/README
- PubMed Central's articlesEach article's own license. Its words show only under CC0, CC BY or public domain
- NLM's PMC Article DatasetsNLM's PMC Article Datasets on AWS, https://registry.opendata.aws/ncbi-pmc. Its terms: users "acknowledge NLM as the source of the data in a clear and conspicuous manner", do not use the PubMed Central wordmark or the PMC logo, do not "indicate or imply that NLM/NIH/HHS has endorsed" a product, and "only distribute data that are licensed for redistribution". Each article keeps its own license: https://pmc.ncbi.nlm.nih.gov/about/copyright/
- PubMedNLM's terms
Cellosaurus, SIB Swiss Institute of Bioinformatics, https://www.cellosaurus.org, CC BY 4.0. Its problem notes are given in its own words.
For software
Read this cell line from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/cell-lines/v1/CVCL_8811
GET https://conductscience.org/api/cell-lines/v1/CVCL_8811/problems