Comparison · NCT00090233-dafaa3c7
RotaTeq™ vs Placebo: G1 Serum Neutralizing Antibody (SNA) Responses Against Rotavirus
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. RotaTeq™ vs Placebo: G1 Serum Neutralizing Antibody (SNA) Responses Against Rotavirus. Trial comparisons, record NCT00090233-dafaa3c7. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00090233-dafaa3c7
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.812 | 0.732 | 0.872 | wilson | |
| Risk in group 2 | 0.0899 | 0.0463 | 0.167 | wilson | |
| Risk difference, group 1 minus group 2 | 0.722 | 0.61 | 0.797 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 9.03 | 4.64 | 17.6 | log | |
| Odds ratio, group 1 over group 2 | 43.7 | 18.5 | 104 | log | |
| Number needed to treat, for one more participant with the outcome on RotaTeq™ than on Placebo | 1.38 | 1.26 | 1.64 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | RotaTeq™ | Participants randomized to treatment with RotaTeq™ tested with data available for analysis excluding protocol violators, participants with invalid data based on laboratory determinations, participants with wildtype rotavirus detected in the stool, or with samples taken outside the range of 9 to 33 days postdose 3. | 95 | 117 | OG000 |
| Group 2 | Placebo | Participants randomized to treatment with Placebo tested with data available for analysis excluding protocol violators, participants with invalid data based on laboratory determinations, participants with wildtype rotavirus detected in the stool, or with samples taken outside the range of 9 to 33 days postdose 3. | 8 | 89 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- G1 Serum Neutralizing Antibody (SNA) Responses Against Rotavirus
- Description
- Number of participants with a 3-fold rise or greater in G1 Serum neutralizing antibody (SNA) responses against rotavirus from baseline to postdose 3.
- Time frame
- 14 days following the 3rd vaccination
- Population
- Per Protocol Population among participants in Finland using Per-Protocol Case Definition
Source ClinicalTrials.gov
Trial
- Title
- Rotavirus Efficacy and Safety Trial (REST)(V260-006)
- NCT number
- NCT00090233
- Phases
- PHASE3
- Conditions
- Rotavirus Infections
- Interventions
- Rotateq™, Comparator: Placebo
- Lead sponsor
- Merck Sharp & Dohme LLC
- Results first posted
- 2011-05-05
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00090233?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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