Comparison · NCT00294658-e2169e0b
Thymectomy Plus Prednisone vs Prednisone Alone: Number of Patients With at Least One Serious Adverse Events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Thymectomy Plus Prednisone vs Prednisone Alone: Number of Patients With at Least One Serious Adverse Events. Trial comparisons, record NCT00294658-e2169e0b. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00294658-e2169e0b
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.379 | 0.271 | 0.499 | wilson | |
| Risk in group 2 | 0.55 | 0.425 | 0.669 | wilson | |
| Risk difference, group 1 minus group 2 | -0.171 | -0.331 | 0.00256 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.689 | 0.469 | 1.01 | log | |
| Odds ratio, group 1 over group 2 | 0.499 | 0.245 | 1.02 | log | |
| Number needed to treat, for one fewer participant with the outcome on Thymectomy Plus Prednisone than on Prednisone Alone | 5.84 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Thymectomy Plus Prednisone | Procedure: Extended Transsternal Thymectomy plus prednisone treatment~thymectomy: The thymectomy will be performed as soon as possible after randomization. | 25 | 66 | OG000 |
| Group 2 | Prednisone Alone | Drug: prednisone alone protocol~prednisone: Prednisone regimen will be every other day, starting at 10mg. The dose will increase by 10mg every 2 days to a target dose. | 33 | 60 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Patients With at Least One Serious Adverse Events
- Description
- Number of participant who experienced at least one serious adverse events over 3 years: Thymectomy plus prednisone n=25 (out of 66); Prednisone alone n=33 (out of 60)
- Time frame
- baseline to 3 years
- Population
Source ClinicalTrials.gov
Trial
- Title
- Thymectomy Trial in Non-Thymomatous Myasthenia Gravis Patients Receiving Prednisone Therapy
- NCT number
- NCT00294658
- Phases
- PHASE3
- Conditions
- Myasthenia Gravis
- Interventions
- thymectomy plus prednisone, prednisone alone
- Lead sponsor
- University of Alabama at Birmingham
- Results first posted
- 2017-01-16
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00294658?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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