Comparison · NCT00524472-sae
Hyperinsulinemic-normoglycemic Clamp vs Insulin at the Standard of Care Levels: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Hyperinsulinemic-normoglycemic Clamp vs Insulin at the Standard of Care Levels: serious adverse events. Trial comparisons, record NCT00524472-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00524472-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0254 | 0.0161 | 0.0398 | wilson | |
| Risk in group 2 | 0.037 | 0.0255 | 0.0533 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0116 | -0.0303 | 0.00678 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.686 | 0.381 | 1.24 | log | |
| Odds ratio, group 1 over group 2 | 0.678 | 0.37 | 1.24 | log | |
| Number needed to treat, for one fewer participant with a serious adverse event on Hyperinsulinemic-normoglycemic Clamp than on Insulin at the Standard of Care Levels | 86.2 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: standard of care.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Hyperinsulinemic-normoglycemic Clamp | Patients will be randomized to receive the hyperinsulinemic-normoglycemic clamp titrating the blood glucose to 80-110 mg/dL.~Hyperinsulinemic-normoglycemic clamp: Patients will be randomized to receive the hyperinsulinemic-normoglycemic clamp titrating the blood glucose to 80-110 mg/dL. | 18 | 709 | EG000 |
| Group 2 | Insulin at the Standard of Care Levels | Group B will be administered insulin at the standard of care levels established by the participating institution.~insulin at the standard of care levels: Subjects will be administered insulin at the standard of care levels established by the participating institution. | 27 | 730 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- One Year Post-opeperative follow-up for All-Cause Mortality; 1 month Post-opeperative follow-up for Serious Adverse Events and Other (Not Including Serious) Adverse Events
Source ClinicalTrials.gov
Trial
- Title
- Outcomes Study of Hyperinsulinemic Glucose Control in Cardiac Surgery
- NCT number
- NCT00524472
- Phases
- NA
- Conditions
- Cardiac Surgery
- Interventions
- Hyperinsulinemic-normoglycemic clamp, insulin at the standard of care levels
- Lead sponsor
- The Cleveland Clinic
- Results first posted
- 2018-10-26
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00524472?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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