Comparison · NCT00623805-sae
Bevacizumab+Capecitabine+Oxaliplatin vs Bevacizumab(B)+Capecitabine(C)+Oxaliplatin Followed by B+C: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Bevacizumab+Capecitabine+Oxaliplatin vs Bevacizumab(B)+Capecitabine(C)+Oxaliplatin Followed by B+C: serious adverse events. Trial comparisons, record NCT00623805-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00623805-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.194 | 0.114 | 0.309 | wilson | |
| Risk in group 2 | 0.344 | 0.237 | 0.47 | wilson | |
| Risk difference, group 1 minus group 2 | -0.151 | -0.299 | 0.0062 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.562 | 0.304 | 1.04 | log | |
| Odds ratio, group 1 over group 2 | 0.457 | 0.201 | 1.04 | log | |
| Number needed to treat, for one fewer participant with a serious adverse event on Bevacizumab+Capecitabine+Oxaliplatin than on Bevacizumab(B)+Capecitabine(C)+Oxaliplatin Followed by B+C | 6.64 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Bevacizumab+Capecitabine+Oxaliplatin | Participants received bevacizumab 7.5 mg/kg intravenously (IV) on Day 1 of each 3-week cycle + oxaliplatin 130 mg/m\^2 IV on Day 1 of each 3-week cycle + capecitabine 1000 mg/m\^2 orally twice a day on Days 1-14 of each 3-week cycle until disease progression. | 12 | 62 | EG000 |
| Group 2 | Bevacizumab(B)+Capecitabine(C)+Oxaliplatin Followed by B+C | Participants received bevacizumab 7.5 mg/kg intravenously (IV) on Day 1 of each 3-week cycle + oxaliplatin 130 mg/m\^2 IV on Day 1 of each 3-week cycle + capecitabine 1000 mg/m\^2 orally twice a day on Days 1-14 of each 3-week cycle for 6 cycles followed by bevacizumab 7.5 mg/kg intravenously (IV) on Day 1 of each 3-week cycle + capecitabine 1000 mg/m\^2 orally twice a day on Days 1-14 of each 3-week cycle until disease progression. | 21 | 61 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
Source ClinicalTrials.gov
Trial
- Title
- A Study of Avastin (Bevacizumab) and Xeloda (Capecitabine) as Maintenance Treatment in Patients With Metastatic Colorectal Cancer
- NCT number
- NCT00623805
- Phases
- PHASE3
- Conditions
- Colorectal Cancer
- Interventions
- Bevacizumab, Capecitabine, Oxaliplatin
- Lead sponsor
- Hoffmann-La Roche
- Results first posted
- 2014-08-08
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00623805?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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