Comparison · NCT00678080-a13501e8
Metformin vs Insulin: Number of Participants Who Had a Newborn With Respiratory Distress Syndrome
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Metformin vs Insulin: Number of Participants Who Had a Newborn With Respiratory Distress Syndrome. Trial comparisons, record NCT00678080-a13501e8. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00678080-a13501e8
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.125 | 0.0224 | 0.471 | wilson | |
| Risk in group 2 | 0.231 | 0.0818 | 0.503 | wilson | |
| Risk difference, group 1 minus group 2 | -0.106 | -0.396 | 0.271 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.542 | 0.0673 | 4.36 | log | |
| Odds ratio, group 1 over group 2 | 0.476 | 0.0407 | 5.58 | log | |
| Number needed to treat, for one fewer participant with the outcome on Metformin than on Insulin | 9.45 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Metformin | Metformin therapy~Metformin: Metformin 500 mg orally daily increased as needed to maintain glycemic control until a maximum of 2500 daily | 1 | 8 | OG000 |
| Group 2 | Insulin | Insulin~Insulin (NPH and Regular): Insulin will be administered based on maternal gestational age and maternal weight using NPH and Regular insulin. It will be administered subcutaneously 3 times a day | 3 | 13 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Participants Who Had a Newborn With Respiratory Distress Syndrome
- Description
- Time frame
- Neonatal period
- Population
Source ClinicalTrials.gov
Trial
- Title
- Metformin Versus Insulin in Pregnant Women With Type 2 Diabetes
- NCT number
- NCT00678080
- Phases
- NA
- Conditions
- Pregnancy Complications
- Interventions
- Metformin, Insulin (NPH and Regular)
- Lead sponsor
- The University of Texas Health Science Center, Houston
- Results first posted
- 2018-11-28
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00678080?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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