Comparison · NCT00758667-a05974bc
Standard vs Mesna: Compare Number of Patients With Capsular Contracture in Mesna Group vs Standard of Care
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Standard vs Mesna: Compare Number of Patients With Capsular Contracture in Mesna Group vs Standard of Care. Trial comparisons, record NCT00758667-a05974bc. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00758667-a05974bc
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.222 | 0.0632 | 0.547 | wilson | |
| Risk in group 2 | 0.364 | 0.152 | 0.646 | wilson | |
| Risk difference, group 1 minus group 2 | -0.141 | -0.466 | 0.247 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.611 | 0.143 | 2.61 | log | |
| Odds ratio, group 1 over group 2 | 0.5 | 0.068 | 3.67 | log | |
| Number needed to treat, for one fewer participant with the outcome on Standard than on Mesna | 7.07 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Standard | Standard procedure or capsulectomy for removal of capsule; no mesna~Mesna: A. Mesna will be used to aid in the removal of the capsule when capsulectomy is performed | 2 | 9 | OG000 |
| Group 2 | Mesna | The use of Mesna of removal of capsule for capsular contracture.~Mesna: A. Mesna will be used to aid in the removal of the capsule when capsulectomy is performed | 4 | 11 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- Compare Number of Patients With Capsular Contracture in Mesna Group vs Standard of Care
- Description
- Time frame
- one year
- Population
Source ClinicalTrials.gov
Trial
- Title
- Chemically Assisted Capsulectomy-A New Clinical Approach
- NCT number
- NCT00758667
- Phases
- NA
- Conditions
- Implant Capsular Contracture
- Interventions
- Mesna
- Lead sponsor
- Vanderbilt University
- Results first posted
- 2014-12-10
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00758667?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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