Comparison · NCT00950651-sae
Tramadol HCl Contramid® Once A Day vs Tramadol HCl Twice a Day (SR): serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Tramadol HCl Contramid® Once A Day vs Tramadol HCl Twice a Day (SR): serious adverse events. Trial comparisons, record NCT00950651-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00950651-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.014 | 0.00476 | 0.0402 | wilson | |
| Risk in group 2 | 0.0372 | 0.019 | 0.0717 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0233 | -0.0589 | 0.00872 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.375 | 0.101 | 1.39 | log | |
| Odds ratio, group 1 over group 2 | 0.366 | 0.0958 | 1.4 | log | |
| Number needed to treat, for one fewer participant with a serious adverse event on Tramadol HCl Contramid® Once A Day than on Tramadol HCl Twice a Day (SR) | 43 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Tramadol HCl Contramid® Once A Day | The available doses for Tramadol HCl Contramid Once A Day (OAD) were 100 mg, 200 mg, 300 mg or 400 mg daily. Each patient was titrated to his/her optimum dose (based on efficacy and tolerability) and maintained that dose until the end of the study. | 3 | 215 | EG000 |
| Group 2 | Tramadol HCl Twice a Day (SR) | The available doses for Tramadol HCl Twice a day (SR) were 200 mg, 300 mg or 400 mg daily. Each patient was titrated to his/her optimum dose (based on efficacy and tolerability) and maintained that dose until the end of the study. | 8 | 215 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
Source ClinicalTrials.gov
Trial
- Title
- A Comparison of the Analgesic Efficacy and Safety of Once Daily Tramadol HCl / Contramid® Tablets to Twice Daily Tramadol HCl (SR) for the Treatment of Osteoarthritis of the Knee
- NCT number
- NCT00950651
- Phases
- PHASE3
- Conditions
- Osteoarthritis, Knee, Pain
- Interventions
- Tramadol HCl Contramid® Once A Day, Tramadol HCl Twice a day
- Lead sponsor
- Labopharm Inc.
- Results first posted
- 2009-08-03
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00950651?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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