Comparison · NCT01876368-e084c2f3
LCZ696 200 mg vs Olmesartan 20 mg: Number of Patients Achieving Successful Mean Sitting Systolic Blood Pressure (msSBP) Control
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. LCZ696 200 mg vs Olmesartan 20 mg: Number of Patients Achieving Successful Mean Sitting Systolic Blood Pressure (msSBP) Control. Trial comparisons, record NCT01876368-e084c2f3. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT01876368-e084c2f3
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.447 | 0.378 | 0.518 | wilson | |
| Risk in group 2 | 0.31 | 0.248 | 0.38 | wilson | |
| Risk difference, group 1 minus group 2 | 0.137 | 0.0385 | 0.231 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.44 | 1.1 | 1.88 | log | |
| Odds ratio, group 1 over group 2 | 1.8 | 1.18 | 2.74 | log | |
| Number needed to treat, for one more participant with the outcome on LCZ696 200 mg than on Olmesartan 20 mg | 7.32 | 4.33 | 26 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | LCZ696 200 mg | Patients will be treated with one LCZ696 200 mg tablet and one placebo of olmesartan 20 mg capsule once daily for 8 weeks. | 84 | 188 | OG000 |
| Group 2 | Olmesartan 20 mg | Patients will be treated with one placebo of LCZ696 200 mg tablet and one olmesartan 20 mg capsule once daily for 8 weeks. | 58 | 187 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Patients Achieving Successful Mean Sitting Systolic Blood Pressure (msSBP) Control
- Description
- Successful mean sitting systolic blood pressure control is defined as msSBP \<140 mmHg
- Time frame
- 8 weeks
- Population
Full Analysis Set (FAS) - All patients who were randomized. Following the intent to treat principle, patients were analyzed according to the treatment they were assigned to at the randomization. However, patients who were not qualified for randomization and were inadvertently randomized into the study were excluded from the FAS.
Source ClinicalTrials.gov
Trial
- Title
- Efficacy and Safety of LCZ696 Compared to Olmesartan in Essential Hypertensive Patients Not Responsive to Olmesartan
- NCT number
- NCT01876368
- Phases
- PHASE3
- Conditions
- Hypertension
- Interventions
- LCZ696, Olmesartan, Placebo of LCZ696, Placebo of Olmesartan
- Lead sponsor
- Novartis Pharmaceuticals
- Results first posted
- 2015-12-07
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT01876368?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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