Comparison · NCT01926496-ede911f7
Ingenol Mebutate vs Imiquimod: Number of Participants With Partial Clearance of AK Lesions
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Ingenol Mebutate vs Imiquimod: Number of Participants With Partial Clearance of AK Lesions. Trial comparisons, record NCT01926496-ede911f7. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT01926496-ede911f7
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.813 | 0.758 | 0.857 | wilson | |
| Risk in group 2 | 0.857 | 0.808 | 0.895 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0446 | -0.111 | 0.0217 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.948 | 0.876 | 1.03 | log | |
| Odds ratio, group 1 over group 2 | 0.722 | 0.446 | 1.17 | log | |
| Number needed to treat, for one fewer participant with the outcome on Ingenol Mebutate than on Imiquimod | 22.4 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Ingenol Mebutate | Arm A: Ingenol mebutate gel 0.015% applied daily for 3 consecutive days to the selected treatment area followed by 8 weeks' rest. Retreatment for another 3 consecutive days if the treatment field is not completely cleared of AKs at Week 8 \>~\> Ingenol Mebutate Gel, 0.015%: Ingenol mebutate gel 0.015 % (Picato®) applied on the selected treatment area. Retreatment if the treatment field is not completely cleared of AKs. | 195 | 240 | OG000 |
| Group 2 | Imiquimod | Arm B: Imiquimod 5% cream applied 3 days per week for 4 weeks to the selected~\> treatment area followed by 4 weeks' rest. Retreatment for another 4 weeks if the treatment field is not completely cleared of AKs at Week 8~\>~\> Imiquimod Cream, 5%: Imiquimod 5% cream applied to the selected treatment area. Retreatment if the treatment field is not completely cleared of AKs | 210 | 245 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Participants With Partial Clearance of AK Lesions
- Description
- To compare the partial (at least 75%) clearance of AK lesions in the selected treatment area after the last treatment cycle (at Week 8 or 16)
- Time frame
- 8-16 weeks
- Population
- Full analysis set: all randomised subjects
Source ClinicalTrials.gov
Trial
- Title
- Risk of Squamous Cell Carcinoma on Skin Areas Treated With Ingenol Mebutate Gel, 0.015% and Imiquimod Cream, 5%
- NCT number
- NCT01926496
- Phases
- PHASE4
- Conditions
- Actinic Keratosis (AK)
- Interventions
- Ingenol Mebutate Gel, 0.015%, Imiquimod Cream, 5%
- Lead sponsor
- LEO Pharma
- Results first posted
- 2020-07-29
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT01926496?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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