Comparison · NCT02568722-sae
Standard RRT Initiation vs Accelerated RRT Initiation: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Standard RRT Initiation vs Accelerated RRT Initiation: serious adverse events. Trial comparisons, record NCT02568722-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02568722-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.00537 | 0.00272 | 0.0106 | wilson | |
| Risk in group 2 | 0.00998 | 0.00606 | 0.0164 | wilson | |
| Risk difference, group 1 minus group 2 | -0.00461 | -0.0116 | 0.0019 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.538 | 0.229 | 1.27 | log | |
| Odds ratio, group 1 over group 2 | 0.536 | 0.227 | 1.27 | log | |
| Number needed to treat, for one fewer participant with a serious adverse event on Standard RRT Initiation than on Accelerated RRT Initiation | 217 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Standard RRT Initiation | RRT initiation will be guided by the presence of one or more clinical indications. Even in the absence of one of these indications, RRT may be commenced at the discretion of the treating physician.~Standard RRT initiation: In the absence of kidney function recovery, the initiation of RRT will be permitted if one of the following develops:~serum potassium ≥ 6.0 mmol/L; pH ≤ 7.20 or serum bicarbonate ≤ 12 mmol/L; evidence of severe respiratory failure, based on a PaO2/FiO2 ≤ 200 and clinical perception of volume overload; and/or persistent AKI \> 72 hours following the time of randomization. | 8 | 1,489 | EG000 |
| Group 2 | Accelerated RRT Initiation | A dialysis catheter will be placed and RRT initiated as soon as possible and within 12 hours of the patient meeting the eligibility criteria.~Accelerated RRT initiation: A dialysis catheter will be placed and RRT initiated as soon as possible and within 12 hours of eligibility. This 12 hour window includes the time needed to obtain consent. | 15 | 1,503 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- Through study completion, 90 days following study randomization
Source ClinicalTrials.gov
Trial
- Title
- Standard vs. Accelerated Initiation of RRT in Acute Kidney Injury (STARRT-AKI: Principal Trial)
- NCT number
- NCT02568722
- Phases
- NA
- Conditions
- Acute Kidney Injury
- Interventions
- Standard RRT initiation, Accelerated RRT initiation
- Lead sponsor
- Unity Health Toronto
- Results first posted
- 2024-10-18
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02568722?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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