Trial · NCT02568722

Standard vs. Accelerated Initiation of RRT in Acute Kidney Injury (STARRT-AKI: Principal Trial)

NCT02568722, Not applicable, Completed, Unity Health Toronto; results first posted 2024-10-18

3 sourcestrials-2026-11-12-0.5.0

Cite this record

ConductScience Library. Standard vs. Accelerated Initiation of RRT in Acute Kidney Injury (STARRT-AKI: Principal Trial). Trials, record NCT02568722. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT02568722

On this page

Trial

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Title: Standard vs. Accelerated Initiation of RRT in Acute Kidney Injury (STARRT-AKI: Principal Trial)
NCT number: NCT02568722
Status: Completed
Phases: Not applicable
Enrollment: 3,019 participants, actual
Lead sponsor: Unity Health Toronto
Conditions: Acute Kidney Injury
Interventions: Standard RRT initiation, Accelerated RRT initiation
First posted: 2015-10-06
Last updated: 2024-10-18
Results first posted: 2024-10-18

Source ClinicalTrials.gov

Registered outcomes14

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

List	Outcome	Time frame	Description
Primary	All-cause Mortality.	90 days following study randomization.
Secondary	RRT Dependence	90 days following study randomization.
Secondary	Composite of Death or RRT Dependence.	90 days following study randomization.
Secondary	Measurement of Estimated Glomerular Filtration Rate.	90 days following study randomization.
Secondary	Measurement of Albuminuria.	90 days following study randomization.
Secondary	Major Adverse Kidney Outcomes.	90 days following study randomization.	Defined as death, RRT dependence or sustained reduction in kidney function (defined as eGFR \< 75% baseline eGFR).
Secondary	Mechanical Ventilation-free Days.	Measured from randomization through day 28.
Secondary	Vasoactive Therapy-free Days	Measured from randomization through day 28.
Secondary	ICU-free Days	Measured from randomization through day 28.
Secondary	Hospitalization-free Days	Measured from randomization through day 90.

1 to 10 of 14Source ClinicalTrials.gov

See all 14 registered outcomes

Outcomes14

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

Type	Outcome	Time frame	Units	Measured as
PRIMARY	All-cause Mortality.	90 days following study randomization.	Participants	COUNT_OF_PARTICIPANTS
SECONDARY	RRT Dependence	90 days following study randomization.
SECONDARY	Composite of Death or RRT Dependence.	90 days following study randomization.
SECONDARY	Measurement of Estimated Glomerular Filtration Rate.	90 days following study randomization.
SECONDARY	Measurement of Albuminuria.	90 days following study randomization.
SECONDARY	Major Adverse Kidney Outcomes.	90 days following study randomization.
SECONDARY	Mechanical Ventilation-free Days.	Measured from randomization through day 28.
SECONDARY	Vasoactive Therapy-free Days	Measured from randomization through day 28.
SECONDARY	ICU-free Days	Measured from randomization through day 28.
SECONDARY	Hospitalization-free Days	Measured from randomization through day 90.

1 to 10 of 14Source ClinicalTrials.gov

See all 14 outcomes

Results by group2

Each measurement the trial posted, group by group, in the words and numbers it posted.

Outcome	Group	Category	Value	Spread	Units
All-cause Mortality.	Standard RRT Initiation		639		Participants
All-cause Mortality.	Accelerated RRT Initiation		643		Participants

Source ClinicalTrials.gov

Participant flow12

How many started, completed or left each group, period by period.

Period	Milestone	Group	Participants
Overall Study	STARTED	Standard RRT Initiation	1,507
Overall Study	STARTED	Accelerated RRT Initiation	1,512
Overall Study	Withdrew Consent	Standard RRT Initiation	18
Overall Study	Withdrew Consent	Accelerated RRT Initiation	9
Overall Study	Randomized Non-eligible	Standard RRT Initiation	19
Overall Study	Randomized Non-eligible	Accelerated RRT Initiation	31
Overall Study	Lost to Follow-up	Standard RRT Initiation	8
Overall Study	Lost to Follow-up	Accelerated RRT Initiation	7
Overall Study	COMPLETED	Standard RRT Initiation	1,462
Overall Study	COMPLETED	Accelerated RRT Initiation	1,465

1 to 10 of 12Source ClinicalTrials.gov

See all 12 participant flow

Adverse events44

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

Type	Event	Organ system	Group	Affected	At risk	Events
other	Hypotension	Vascular disorders	Standard RRT Initiation	131	1,489	188
other	Hypotension	Vascular disorders	Accelerated RRT Initiation	83	1,503	112
other	Arrhythmia	Cardiac disorders	Standard RRT Initiation	23	1,489	29
other	Arrhythmia	Cardiac disorders	Accelerated RRT Initiation	37	1,503	45
other	Seizure	Nervous system disorders	Standard RRT Initiation	0	1,489	0
other	Seizure	Nervous system disorders	Accelerated RRT Initiation	1	1,503	1
other	Bleeding	Surgical and medical procedures	Standard RRT Initiation	5	1,489	5
other	Bleeding	Surgical and medical procedures	Accelerated RRT Initiation	10	1,503	10
other	Allergic reaction	Surgical and medical procedures	Standard RRT Initiation	1	1,489	1
other	Allergic reaction	Surgical and medical procedures	Accelerated RRT Initiation	1	1,503	1

1 to 10 of 44Source ClinicalTrials.gov

See all 44 adverse events

Adverse event totals6

The totals the trial posted for each group.

Total	Group	Affected	At risk
Total, all-cause mortality	Standard RRT Initiation	639	1,462
Total, all-cause mortality	Accelerated RRT Initiation	643	1,465
Total, other adverse events	Standard RRT Initiation	245	1,489
Total, other adverse events	Accelerated RRT Initiation	346	1,503
Total, serious adverse events	Standard RRT Initiation	8	1,489
Total, serious adverse events	Accelerated RRT Initiation	15	1,503

Source ClinicalTrials.gov

Papers8

The papers the trial lists on ClinicalTrials.gov.

PMID	Listed as	Source
31218013	DERIVED	PubMed
31462203	DERIVED	PubMed
32668114	DERIVED	PubMed
36416787	DERIVED	PubMed
36424662	DERIVED	PubMed
38380940	DERIVED	PubMed
38461657	DERIVED	PubMed
40232884	DERIVED	PubMed

Grants0

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

None in this release.

Trial comparisons3

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

Comparison	Source
Standard RRT Initiation vs Accelerated RRT Initiation: All-cause Mortality.	Trial comparisons
Standard RRT Initiation vs Accelerated RRT Initiation: deaths from any cause	Trial comparisons
Standard RRT Initiation vs Accelerated RRT Initiation: serious adverse events	Trial comparisons

Tests0

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

None in this release.

Data dates

The day each source was copied for this release.

ClinicalTrials.gov: 2026-11-12; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
NIH grant links: 2026-11-13; NIH RePORTER

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this trial from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/trials/v1/NCT02568722

GET https://conductscience.org/api/trials/v1/NCT02568722/events?page=2

API reference For AI assistants