Comparison · NCT02822573-sae
Donepezil vs Placebo: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Donepezil vs Placebo: serious adverse events. Trial comparisons, record NCT02822573-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02822573-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0857 | 0.0497 | 0.144 | wilson | |
| Risk in group 2 | 0.0588 | 0.0301 | 0.112 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0269 | -0.0371 | 0.0917 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.46 | 0.615 | 3.45 | log | |
| Odds ratio, group 1 over group 2 | 1.5 | 0.593 | 3.79 | log | |
| Number needed to harm, for one more participant with a serious adverse event on Donepezil than on Placebo | 37.2 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Donepezil | Participants will be asked to take one 5 mg tablet of donepezil daily for 6 weeks followed by two 5 mg tablets daily for 18 weeks. After 24 weeks, participants will begin a 12 week wash-out period.~Donepezil 5 mg: Participants will be asked to take one 5 mg tablet of donepezil daily for 6 weeks followed by two 5mg tablets daily for 18 weeks. After 24 weeks, participants will begin a 12 week wash-out period. | 12 | 140 | EG000 |
| Group 2 | Placebo | Participants will be asked to take one tablet of matching placebo daily for 6 weeks followed by two tablets daily for 18 weeks. After 24 weeks, participants will begin a 12 week wash-out period.~Placebo: Participants will be asked to take one tablet of matching placebo daily for 6 weeks followed by two tablets daily for 18 weeks. After 24 weeks, participants will begin a 12 week wash-out period. | 8 | 136 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- Adverse events were collected at baseline, 3 weeks, 6 weeks, 12 weeks, 24 weeks, and 36 weeks. And participants could report additional events at any time.
Source ClinicalTrials.gov
Trial
- Title
- Phase 3 Randomized Placebo Controlled Clinical Trial of Donepezil
- NCT number
- NCT02822573
- Phases
- PHASE3
- Conditions
- Cognitive Dysfunction, Memory Impairment
- Interventions
- Donepezil 5 mg, Placebo
- Lead sponsor
- Wake Forest University Health Sciences
- Results first posted
- 2023-09-13
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02822573?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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