Comparison · NCT03075891-sae
Ivermectin 1% Cream + Doxycycline 40 mg MR Capsules vs Ivermectin 1% Cream + Oral Placebo Capsules: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Ivermectin 1% Cream + Doxycycline 40 mg MR Capsules vs Ivermectin 1% Cream + Oral Placebo Capsules: serious adverse events. Trial comparisons, record NCT03075891-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03075891-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.00741 | 0.00131 | 0.0408 | wilson | |
| Risk in group 2 | 0.00725 | 0.00128 | 0.0399 | wilson | |
| Risk difference, group 1 minus group 2 | 0.000161 | -0.0331 | 0.034 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.02 | 0.0646 | 16.2 | log | |
| Odds ratio, group 1 over group 2 | 1.02 | 0.0633 | 16.5 | log | |
| Number needed to harm, for one more participant with a serious adverse event on Ivermectin 1% Cream + Doxycycline 40 mg MR Capsules than on Ivermectin 1% Cream + Oral Placebo Capsules | 6,210 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Ivermectin 1% Cream + Doxycycline 40 mg MR Capsules | Ivermectin 1% cream: Topical to the face, approximately one small pea size amount per facial region (right and left cheeks, forehead, chin, and nose) once a day for 12 weeks~Doxycycline 40 mg MR (30 mg Immediate Release \& 10 mg Delayed Release beads) capsules: 1 Capsule once-daily for 12 weeks | 1 | 135 | EG000 |
| Group 2 | Ivermectin 1% Cream + Oral Placebo Capsules | Ivermectin 1% cream: Topical to the face, approximately one small pea size amount per facial region (right and left cheeks, forehead, chin, and nose) once a day for 12 weeks~Oral placebo capsules: 1 Capsule once-daily for 12 weeks | 1 | 138 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- From the signing of the informed consent form (ICF) up to week 12
Source ClinicalTrials.gov
Trial
- Title
- Oracea Soolantra Association in Participants With Severe Rosacea
- NCT number
- NCT03075891
- Phases
- PHASE4
- Conditions
- Rosacea
- Interventions
- Ivermectin 1% cream, Doxycycline 40 mg MR (30 mg Immediate Release & 10 mg Delayed Release beads) capsules, Oral placebo capsules
- Lead sponsor
- Galderma R&D
- Results first posted
- 2019-11-29
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03075891?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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