Comparison · NCT03477006-0445ffa1
LTLR-WB vs Standard Care: Incidence of Multiple Organ Failure
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. LTLR-WB vs Standard Care: Incidence of Multiple Organ Failure. Trial comparisons, record NCT03477006-0445ffa1. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03477006-0445ffa1
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.1 | 0.0396 | 0.231 | wilson | |
| Risk in group 2 | 0.196 | 0.107 | 0.332 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0957 | -0.245 | 0.0624 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.511 | 0.17 | 1.53 | log | |
| Odds ratio, group 1 over group 2 | 0.457 | 0.129 | 1.62 | log | |
| Number needed to treat, for one fewer participant with the outcome on LTLR-WB than on Standard Care | 10.5 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: standard care.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | LTLR-WB | Receiving 2 units of low titer, leucocyte reduced, platelet replete whole blood initiated in the prehospital setting during air medical transport and continued (up to 6 units of whole blood followed by standard component resuscitation) thru the early in-hospital phase of care~Whole blood: Low titer, group O, leukocyte reduced, platelet replete, cold stored whole blood | 4 | 40 | OG000 |
| Group 2 | Standard Care | Receiving standard prehospital air medical care and standard of care component (1:1:1) trauma resuscitation thru the early in-hospital phase of care | 9 | 46 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Incidence of Multiple Organ Failure
- Description
multiple organ failure using the Denver post-injury MOF score which is a summed score and when the score is 4 or greater from 4 organ system scores, MOF is designated; 4 organ systems (pulmonary \[0-3\], renal \[0-3\], hepatic \[0-3\], cardiovascular \[0-3\])
- Time frame
- 28 days from admission
- Population
Source ClinicalTrials.gov
Trial
- Title
- Pragmatic Prehospital Group O Whole Blood Early Resuscitation Trial
- NCT number
- NCT03477006
- Phases
- PHASE3
- Conditions
- Hemorrhagic Shock
- Interventions
- Whole blood
- Lead sponsor
- Jason Sperry
- Results first posted
- 2021-10-06
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03477006?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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