Trial · NCT03477006

Pragmatic Prehospital Group O Whole Blood Early Resuscitation Trial

NCT03477006, Phase 3, Terminated, Jason Sperry; results first posted 2021-10-06

3 sourcestrials-2026-11-12-0.5.0

Cite this record

ConductScience Library. Pragmatic Prehospital Group O Whole Blood Early Resuscitation Trial. Trials, record NCT03477006. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03477006

On this page

Trial

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Title: Pragmatic Prehospital Group O Whole Blood Early Resuscitation Trial
NCT number: NCT03477006
Status: Terminated
Phases: Phase 3
Enrollment: 86 participants, actual
Lead sponsor: Jason Sperry
Conditions: Hemorrhagic Shock
Interventions: Whole blood
First posted: 2018-03-26
Last updated: 2021-10-06
Results first posted: 2021-10-06

Source ClinicalTrials.gov

Registered outcomes3

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

List	Outcome	Time frame	Description
Primary	28 Day All Cause Mortality	28 days from admission	28 day all cause mortality
Secondary	Incidence of Multiple Organ Failure	28 days from admission	multiple organ failure using the Denver post-injury MOF score which is a summed score and when the score is 4 or greater from 4 organ system scores, MOF is designated; 4 organ systems (pulmonary \[0-3\], renal \[0-3\], hepatic \[0-3\], cardiovascular \[0-3\])
Secondary	24 Hour Mortality	24 hours from admission	24 hour mortality

Source ClinicalTrials.gov

Outcomes3

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

Type	Outcome	Time frame	Units	Measured as
PRIMARY	28 Day All Cause Mortality	28 days from admission	Participants	COUNT_OF_PARTICIPANTS
SECONDARY	Incidence of Multiple Organ Failure	28 days from admission	Participants	COUNT_OF_PARTICIPANTS
SECONDARY	24 Hour Mortality	24 hours from admission	Participants	COUNT_OF_PARTICIPANTS

Source ClinicalTrials.gov

Results by group6

Each measurement the trial posted, group by group, in the words and numbers it posted.

Outcome	Group	Value	Units
28 Day All Cause Mortality	LTLR-WB	10	Participants
28 Day All Cause Mortality	Standard Care	12	Participants
Incidence of Multiple Organ Failure	LTLR-WB	4	Participants
Incidence of Multiple Organ Failure	Standard Care	9	Participants
24 Hour Mortality	LTLR-WB	6	Participants
24 Hour Mortality	Standard Care	8	Participants

Source ClinicalTrials.gov

Participant flow6

How many started, completed or left each group, period by period.

Period	Milestone	Group	Participants
Overall Study	STARTED	LTLR-WB	40
Overall Study	STARTED	Standard Care	46
Overall Study	COMPLETED	LTLR-WB	40
Overall Study	COMPLETED	Standard Care	46
Overall Study	NOT COMPLETED	LTLR-WB	0
Overall Study	NOT COMPLETED	Standard Care	0

Source ClinicalTrials.gov

Adverse events14

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

Type	Event	Organ system	Group	Affected	At risk	Events
other	hyponatremia	Metabolism and nutrition disorders	LTLR-WB	0	40	0
other	hyponatremia	Metabolism and nutrition disorders	Standard Care	1	46	1
serious	stroke	Nervous system disorders	LTLR-WB	1	40	1
serious	stroke	Nervous system disorders	Standard Care	3	46	3
serious	ARDS	Respiratory, thoracic and mediastinal disorders	LTLR-WB	3	40	3
serious	ARDS	Respiratory, thoracic and mediastinal disorders	Standard Care	1	46	1
serious	DVT	Blood and lymphatic system disorders	LTLR-WB	1	40	1
serious	DVT	Blood and lymphatic system disorders	Standard Care	3	46	3
serious	pulmonary embolus	Respiratory, thoracic and mediastinal disorders	LTLR-WB	1	40	1
serious	pulmonary embolus	Respiratory, thoracic and mediastinal disorders	Standard Care	1	46	1

1 to 10 of 14Source ClinicalTrials.gov

See all 14 adverse events

Adverse event totals6

The totals the trial posted for each group.

Total	Group	Affected	At risk
Total, all-cause mortality	LTLR-WB	10	40
Total, all-cause mortality	Standard Care	12	46
Total, other adverse events	LTLR-WB	0	40
Total, other adverse events	Standard Care	1	46
Total, serious adverse events	LTLR-WB	7	40
Total, serious adverse events	Standard Care	11	46

Source ClinicalTrials.gov

Papers2

The papers the trial lists on ClinicalTrials.gov.

PMID	Listed as	Source
35081595	DERIVED	PubMed
38933603	DERIVED	PubMed

Grants1

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

Project	Title	Principal investigators	Organization	Funder	Fiscal years
R34HL135224	Pragmatic, Prehospital Group O Whole Blood Early Resuscitation Pilot Trial	SPERRY, JASON LEE; TRIULZI, DARRELL J	UNIVERSITY OF PITTSBURGH AT PITTSBURGH	NATIONAL HEART, LUNG, AND BLOOD INSTITUTE	2017 to 2019

Source NIH RePORTER

Trial comparisons5

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

Comparison	Source
LTLR-WB vs Standard Care: Incidence of Multiple Organ Failure	Trial comparisons
LTLR-WB vs Standard Care: 28 Day All Cause Mortality	Trial comparisons
LTLR-WB vs Standard Care: 24 Hour Mortality	Trial comparisons
LTLR-WB vs Standard Care: deaths from any cause	Trial comparisons
LTLR-WB vs Standard Care: serious adverse events	Trial comparisons

Tests0

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

None in this release.

Data dates

The day each source was copied for this release.

ClinicalTrials.gov: 2026-11-12; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
NIH grant links: 2026-11-13; NIH RePORTER

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this trial from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/trials/v1/NCT03477006

GET https://conductscience.org/api/trials/v1/NCT03477006/registered

API reference For AI assistants