Comparison · NCT03509350-4c32db7e
Treatment Protocol vs Control Protocol: Intensive Care Unit (ICU) Mortality
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Treatment Protocol vs Control Protocol: Intensive Care Unit (ICU) Mortality. Trial comparisons, record NCT03509350-4c32db7e. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03509350-4c32db7e
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.206 | 0.161 | 0.261 | wilson | |
| Risk in group 2 | 0.197 | 0.152 | 0.251 | wilson | |
| Risk difference, group 1 minus group 2 | 0.00956 | -0.0608 | 0.0798 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.05 | 0.74 | 1.49 | log | |
| Odds ratio, group 1 over group 2 | 1.06 | 0.686 | 1.64 | log | |
| Number needed to treat, for one more participant with the outcome on Treatment Protocol than on Control Protocol | 105 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: control.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Treatment Protocol | Participants randomized to the treatment protocol received the VICTAS Intervention, consisting of intravenous vitamin C, thiamine, and hydrocortisone for four days or until ICU discharge. | 52 | 252 | OG000 |
| Group 2 | Control Protocol | Participants in the control group received a placebo to match the VICTAS intervention, which was administered for four days or until ICU discharge. | 49 | 249 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Intensive Care Unit (ICU) Mortality
- Description
- The number of participants who died while in the ICU is compared between study arms.
- Time frame
- Day 30
- Population
Source ClinicalTrials.gov
Trial
- Title
- Vitamin C, Thiamine, and Steroids in Sepsis
- NCT number
- NCT03509350
- Phases
- PHASE3
- Conditions
- Sepsis
- Interventions
- Vitamin C, Thiamine, Hydrocortisone, Vitamin C Placebo, Thiamine Placebo, Hydrocortisone Placebo
- Lead sponsor
- Emory University
- Results first posted
- 2020-09-18
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03509350?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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