Comparison · NCT03584373-sae
Non-Opioid Analgesia vs Opioid Analgesia: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Non-Opioid Analgesia vs Opioid Analgesia: serious adverse events. Trial comparisons, record NCT03584373-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03584373-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.098 | 0.0426 | 0.21 | wilson | |
| Risk in group 2 | 0.13 | 0.0642 | 0.244 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0316 | -0.159 | 0.0979 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.756 | 0.256 | 2.23 | log | |
| Odds ratio, group 1 over group 2 | 0.73 | 0.216 | 2.47 | log | |
| Number needed to treat, for one fewer participant with a serious adverse event on Non-Opioid Analgesia than on Opioid Analgesia | 31.7 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Non-Opioid Analgesia | Ketorolac - Oral; 10 mg tablet: 1 tablet every 6 hours, or as needed. (20 tablets prescribed).~Acetaminophen - Oral; patient directed as needed. Not prescribed.~Ketorolac and Acetaminophen administered post surgery to compare pain outcomes to that of Percocet.~Ketorolac Oral Tablet \[Toradol\]: Ketorolac is a prescribed NSAID with strong analgesic activity. Ketorolac will be administered post surgery to compare pain outcomes to that of Percocet.~Acetaminophen: Acetaminophen is an over-the counter pain medication that will be administered post surgery to compare pain outcomes to that of Percocet. | 5 | 51 | EG000 |
| Group 2 | Opioid Analgesia | Percocet - Oral; 5 mg tablet: 1 tablet every 4-6 hours, or as needed. (10 tablets prescribed).~Percocet administered post surgery to compare pain outcomes to that of the non-opioid analgesia.~Oxycodone Acetaminophen: Percocet is a prescribed opioid medication to manage pain. Percocet will be administered post surgery to compare pain outcomes to that of non-opioid analgesia. | 7 | 54 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- Up to 1 week postoperatively
Source ClinicalTrials.gov
Trial
- Title
- Pain Outcomes of Non-opioid vs. Opioid Analgesia for Kidney Stone Surgery.
- NCT number
- NCT03584373
- Phases
- PHASE3
- Conditions
- Nephrolithiasis
- Interventions
- Ketorolac Oral Tablet [Toradol], Acetaminophen, Oxycodone Acetaminophen
- Lead sponsor
- Montefiore Medical Center
- Results first posted
- 2023-12-18
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03584373?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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Read this comparison from software.
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GET https://conductscience.org/api/comparisons/v1/NCT03584373-sae