Comparison · NCT03658642-465c1396
Clinical Decision Support for BUP vs Usual Care: Number of Clinicians Providing Referral of Any Ongoing MOUD Treatment
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Clinical Decision Support for BUP vs Usual Care: Number of Clinicians Providing Referral of Any Ongoing MOUD Treatment. Trial comparisons, record NCT03658642-465c1396. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03658642-465c1396
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.415 | 0.364 | 0.468 | wilson | |
| Risk in group 2 | 0.386 | 0.329 | 0.447 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0286 | -0.0506 | 0.107 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.07 | 0.88 | 1.31 | log | |
| Odds ratio, group 1 over group 2 | 1.13 | 0.81 | 1.57 | log | |
| Number needed to treat, for one more participant with the outcome on Clinical Decision Support for BUP than on Usual Care | 35 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: usual care.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Clinical Decision Support for BUP | The Clinical Decision Support (CDS) will be available for clinician use for Emergency Department (ED)-initiated buprenorphine/naloxone (BUP) with referral for ongoing medication assisted treatment (MAT) if: ED chief complaint or urine drug screen indicate opioid use. The clinician will then be prompted to complete DSM-5 checklist for OUD. If DSM-5 OUD Score\>5 and urine drug screen is positive for opioids, then the clinician is prompted to complete COWS scale. If COWS score \>12, then the clinician is prompted to order BUP. Regardless of COWS score, the clinician will be prompted to schedule an MAT appointment with BUP provider. The CDS will interface with outside MAT facilities so that making an appointment is easy and to capture data on whether an appointment has been scheduled.~Clinical Decision Support (CDS): This clinical decision support tool will improve the clinician's ability to identify those with OUD, initiate BUP and refer the patient to ongoing Medication Assisted Treatment (MAT) | 141 | 340 | OG000 |
| Group 2 | Usual Care | The CDS will not be activated and patients will receive care as usual. | 100 | 259 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Clinicians Providing Referral of Any Ongoing MOUD Treatment
- Description
- Number of clinicians that refer patients with OUD regardless of CDS
- Time frame
- 18 months
- Population
- Clinicians participating in the study.
Source ClinicalTrials.gov
Trial
- Title
- Clinical Decision Support to Implement ED-initiated Buprenorphine for OUD
- NCT number
- NCT03658642
- Phases
- NA
- Conditions
- Clinical Decision Support, Buprenorphine, Opioid-use Disorder
- Interventions
- Clinical Decision Support (CDS)
- Lead sponsor
- Yale University
- Results first posted
- 2022-06-28
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03658642?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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