Trial · NCT03658642
Clinical Decision Support to Implement ED-initiated Buprenorphine for OUD
NCT03658642, Not applicable, Completed, Yale University; results first posted 2022-06-28
3 sourcestrials-2026-11-12-0.4.0
Cite this record
ConductScience Library. Clinical Decision Support to Implement ED-initiated Buprenorphine for OUD. Trials, record NCT03658642. Release trials-2026-11-12-0.4.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03658642
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Clinical Decision Support to Implement ED-initiated Buprenorphine for OUD
- NCT number
- NCT03658642
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 5,047 participants, actual
- Lead sponsor
- Yale University
- Conditions
- Clinical Decision Support, Buprenorphine, Opioid-use Disorder
- Interventions
- Clinical Decision Support (CDS)
- First posted
- 2018-09-05
- Last updated
- 2022-06-28
- Results first posted
- 2022-06-28
Source ClinicalTrials.gov
Registered outcomes6
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Count of Initiating BUP in the ED With Referral for Ongoing MOUD With User-centered CDS Compared With Usual Care | Upon discharge (Up to 1 day) | The primary outcome will be Buprenorphine (BUP) initiation in the Emergency Department (ED), defined as whether or not an eligible patient is administered BUP in the ED and/or prescribed BUP upon discharge from the ED. Although this is not a patient-centered outcome, it is a pragmatic and meaningful surrogate that will serve as a lead indicator of the CDS intervention's effect on engaging more OUD patients in treatment. Medications for Opioid Use Disorder (MOUD) |
| Secondary | Count of Those With Referral to Follow-up for Ongoing MOUD Treatment (Patient Level) | Upon discharge (Up to 1 day) | The count of enrolled patients who receive an Medication Assisted Therapy (MAT) appointment. Medications for Opioid Use Disorder (MOUD) |
| Secondary | Rates Receiving a MAT Appointment Who go to the Appointment | 18 months | Data will be collected in the aggregate for the percentage of patients that attended the referral MAT appointment |
| Secondary | Number of Clinicians Providing ED-initiated BUP | 18 months | Number of clinicians providing ED-initiated BUP regardless of CDS |
| Secondary | Number of Clinicians Providing Referral of Any Ongoing MOUD Treatment | 18 months | Number of clinicians that refer patients with OUD regardless of CDS |
| Secondary | Number of Clinicians Who Have Received Drug Addiction Treatment Act (DATA) of 2000 Training | 18 months | Number of clinicians that obtained DATA waiver |
Source ClinicalTrials.gov
Outcomes6
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Count of Initiating BUP in the ED With Referral for Ongoing MOUD With User-centered CDS Compared With Usual Care | Upon discharge (Up to 1 day) | Participants | COUNT_OF_PARTICIPANTS | |
| SECONDARY | Count of Those With Referral to Follow-up for Ongoing MOUD Treatment (Patient Level) | Upon discharge (Up to 1 day) | Participants | COUNT_OF_PARTICIPANTS | |
| SECONDARY | Rates Receiving a MAT Appointment Who go to the Appointment | 18 months | These data were not able to be obtained. | ||
| SECONDARY | Number of Clinicians Providing ED-initiated BUP | 18 months | Clinicians participating in the study. | Participants | COUNT_OF_PARTICIPANTS |
| SECONDARY | Number of Clinicians Providing Referral of Any Ongoing MOUD Treatment | 18 months | Clinicians participating in the study. | Participants | COUNT_OF_PARTICIPANTS |
| SECONDARY | Number of Clinicians Who Have Received Drug Addiction Treatment Act (DATA) of 2000 Training | 18 months | Clinicians participating in the study. | Participants | COUNT_OF_PARTICIPANTS |
Source ClinicalTrials.gov
Results by group10
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Count of Initiating BUP in the ED With Referral for Ongoing MOUD With User-centered CDS Compared With Usual Care | Clinical Decision Support for BUP | 347 | Participants | ||
| Count of Initiating BUP in the ED With Referral for Ongoing MOUD With User-centered CDS Compared With Usual Care | Usual Care | 271 | Participants | ||
| Count of Those With Referral to Follow-up for Ongoing MOUD Treatment (Patient Level) | Clinical Decision Support for BUP | 367 | Participants | ||
| Count of Those With Referral to Follow-up for Ongoing MOUD Treatment (Patient Level) | Usual Care | 226 | Participants | ||
| Number of Clinicians Providing ED-initiated BUP | Clinical Decision Support for BUP | 151 | Participants | ||
| Number of Clinicians Providing ED-initiated BUP | Usual Care | 88 | Participants | ||
| Number of Clinicians Providing Referral of Any Ongoing MOUD Treatment | Clinical Decision Support for BUP | 141 | Participants | ||
| Number of Clinicians Providing Referral of Any Ongoing MOUD Treatment | Usual Care | 100 | Participants | ||
| Number of Clinicians Who Have Received Drug Addiction Treatment Act (DATA) of 2000 Training | Clinical Decision Support for BUP | 50 | Participants | ||
| Number of Clinicians Who Have Received Drug Addiction Treatment Act (DATA) of 2000 Training | Usual Care | 30 | Participants |
Source ClinicalTrials.gov
Participant flow12
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Patients | STARTED | Clinical Decision Support for BUP | 2,787 | |
| Patients | STARTED | Usual Care | 2,260 | |
| Patients | COMPLETED | Clinical Decision Support for BUP | 2,787 | |
| Patients | COMPLETED | Usual Care | 2,260 | |
| Patients | NOT COMPLETED | Clinical Decision Support for BUP | 0 | |
| Patients | NOT COMPLETED | Usual Care | 0 | |
| Physicians | STARTED | Clinical Decision Support for BUP | 340 | |
| Physicians | STARTED | Usual Care | 259 | |
| Physicians | COMPLETED | Clinical Decision Support for BUP | 340 | |
| Physicians | COMPLETED | Usual Care | 259 |
1 to 10 of 12Source ClinicalTrials.gov
See all 12 participant flowAdverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Clinical Decision Support for BUP | 0 | 2,787 |
| Total, all-cause mortality | Usual Care | 0 | 2,260 |
| Total, other adverse events | Clinical Decision Support for BUP | 0 | 2,787 |
| Total, other adverse events | Usual Care | 0 | 2,260 |
| Total, serious adverse events | Clinical Decision Support for BUP | 0 | 2,787 |
| Total, serious adverse events | Usual Care | 0 | 2,260 |
Source ClinicalTrials.gov
Papers5
The papers the trial lists on ClinicalTrials.gov.
Grants1
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years |
|---|---|---|---|---|---|
| UG3DA047003 | EMBED: Pragmatic trial of user-centered clinical decision support to implement EMergency department-initiated BuprenorphinE for opioid use Disorder | MELNICK, EDWARD ROBERT; D'ONOFRIO, GAIL | YALE UNIVERSITY | NATIONAL INSTITUTE ON DRUG ABUSE | 2018 |
Source NIH RePORTER
Trial comparisons7
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
| Clinical Decision Support for BUP vs Usual Care: Number of Clinicians Providing Referral of Any Ongoing MOUD Treatment | Trial comparisons |
| Clinical Decision Support for BUP vs Usual Care: Number of Clinicians Who Have Received Drug Addiction Treatment Act (DATA) of 2000 Training | Trial comparisons |
| Clinical Decision Support for BUP vs Usual Care: Number of Clinicians Providing ED-initiated BUP | Trial comparisons |
| Clinical Decision Support for BUP vs Usual Care: Count of Those With Referral to Follow-up for Ongoing MOUD Treatment (Patient Level) | Trial comparisons |
| Clinical Decision Support for BUP vs Usual Care: Count of Initiating BUP in the ED With Referral for Ongoing MOUD With User-centered CDS Compared With Usual Care | Trial comparisons |
| Clinical Decision Support for BUP vs Usual Care: deaths from any cause | Trial comparisons |
| Clinical Decision Support for BUP vs Usual Care: serious adverse events | Trial comparisons |
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03658642
GET https://conductscience.org/api/trials/v1/NCT03658642/registered