Comparison · NCT03827018-sae
Mavrilimumab vs Placebo: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Mavrilimumab vs Placebo: serious adverse events. Trial comparisons, record NCT03827018-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03827018-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0476 | 0.0132 | 0.158 | wilson | |
| Risk in group 2 | 0.107 | 0.0371 | 0.272 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0595 | -0.228 | 0.0711 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.444 | 0.0793 | 2.49 | log | |
| Odds ratio, group 1 over group 2 | 0.417 | 0.065 | 2.67 | log | |
| Number needed to treat, for one fewer participant with a serious adverse event on Mavrilimumab than on Placebo | 16.8 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Mavrilimumab | Participants randomized to mavrilimumab receive 150 mg every other week by subcutaneous injection co-administered with a 26-week corticosteroid taper. | 2 | 42 | EG000 |
| Group 2 | Placebo | Participants randomized to placebo receive placebo every other week by subcutaneous injection co-administered with a 26-week corticosteroid taper. | 3 | 28 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
All-Cause Mortality: From signing of informed consent (up to 6 weeks prior to Baseline) through Final Safety Follow-up / Week 38 Adverse Events: from first dose of study drug through Final Safety Follow-up / Week 38
Source ClinicalTrials.gov
Trial
- Title
- KPL-301 for Subjects With Giant Cell Arteritis
- NCT number
- NCT03827018
- Phases
- PHASE2
- Conditions
- Giant Cell Arteritis
- Interventions
- mavrilimumab, placebo, prednisone
- Lead sponsor
- Kiniksa Pharmaceuticals, Ltd.
- Results first posted
- 2023-10-17
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03827018?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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