Comparison · NCT03891667-sae
8 Week Disulfiram vs 4 Week Disulfiram: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. 8 Week Disulfiram vs 4 Week Disulfiram: serious adverse events. Trial comparisons, record NCT03891667-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03891667-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.2 | 0.0362 | 0.624 | wilson | |
| Risk in group 2 | 0.25 | 0.0456 | 0.699 | wilson | |
| Risk difference, group 1 minus group 2 | -0.05 | -0.528 | 0.421 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.8 | 0.0697 | 9.18 | log | |
| Odds ratio, group 1 over group 2 | 0.75 | 0.0321 | 17.5 | log | |
| Number needed to treat, for one fewer participant with a serious adverse event on 8 Week Disulfiram than on 4 Week Disulfiram | 20 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | 8 Week Disulfiram | Patients in this group receive disulfiram for 8 weeks. The dosing schedule is fixed-flexible, starting at 250 mg every other day at week 1, 250 mg daily for week 2, 250 mg alternating with 500 mg for week 3, and 500 mg daily for week 4 to week 8. Dose increases are based on clinical judgment guided by patient tolerance, response, body weight, and side effects.~Disulfiram: Patients will receive disulfiram for 8 weeks . | 1 | 5 | EG000 |
| Group 2 | 4 Week Disulfiram | Patients in this group receive disulfiram for 4 weeks followed by placebo capsules for 4 weeks. The dosing schedule is fixed-flexible, starting at 250 mg every other day at week 1, 250 mg daily for week 2, 250 mg alternating with 500 mg during week 3, and 500 mg daily during week 4. Placebo capsules are given during weeks 5-8. Dose increases are based on clinical judgment guided by patient tolerance, response, body weight, and side effects.~Disulfiram: Patients will receive disulfiram for 4 weeks followed by placebo for 4 weeks . | 1 | 4 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- up to 14 weeks
Source ClinicalTrials.gov
Trial
- Title
- Disulfiram: A Test of Symptom Reduction Among Patients With Previously Treated Lyme Disease
- NCT number
- NCT03891667
- Phases
- PHASE1, PHASE2
- Conditions
- Fatigue, Quality of Life
- Interventions
- Disulfiram
- Lead sponsor
- Research Foundation for Mental Hygiene, Inc.
- Results first posted
- 2023-06-05
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03891667?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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