Comparison · NCT04684238-5b6a9900
Drug: Midazolam vs Drug: Isoflurane: Evaluate the Frequency of Neurological Symptoms or Psychomotor Dysfunction
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Drug: Midazolam vs Drug: Isoflurane: Evaluate the Frequency of Neurological Symptoms or Psychomotor Dysfunction. Trial comparisons, record NCT04684238-5b6a9900. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04684238-5b6a9900
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.182 | 0.0861 | 0.344 | wilson | |
| Risk in group 2 | 0.262 | 0.168 | 0.384 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0805 | -0.236 | 0.107 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.693 | 0.3 | 1.6 | log | |
| Odds ratio, group 1 over group 2 | 0.625 | 0.218 | 1.79 | log | |
| Number needed to treat, for one fewer participant with the outcome on Drug: Midazolam than on Drug: Isoflurane | 12.4 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Drug: Midazolam | Midazolam for sedation in the ICU~Midazolam: Solution for Injection/Infusion | 6 | 33 | OG000 |
| Group 2 | Drug: Isoflurane | Volatile for sedation in the ICU~Isoflurane: Inhalation vapour, liquid. Isoflurane delivered by the AnaConDa-S (Anaesthetic Conserving Device) | 16 | 61 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Evaluate the Frequency of Neurological Symptoms or Psychomotor Dysfunction
- Description
Evaluate the frequency of neurological symptoms or psychomotor dysfunction during and up to 48 hours after discontinuation of isoflurane and midazolam treatment, and the association with duration of treatment, and total exposure (MAC hours and midazolam doses) over time.
- Time frame
- During study treatment and up to 48 hours after discontinuation of isoflurane and midazolam
- Population
Source ClinicalTrials.gov
Trial
- Title
- Effect & Safety of Inhaled Isoflurane vs IV Midazolam for Sedation in Mechanically Ventilated Children 3-17 Years Old
- NCT number
- NCT04684238
- Phases
- PHASE3
- Conditions
- Sedation
- Interventions
- Midazolam, Isoflurane
- Lead sponsor
- Sedana Medical
- Results first posted
- 2025-05-25
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04684238?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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