Comparison · NCT04684238-f50963bc
Drug: Midazolam vs Drug: Isoflurane: Evaluate the Number of Patients With Withdrawal Symptom
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Drug: Midazolam vs Drug: Isoflurane: Evaluate the Number of Patients With Withdrawal Symptom. Trial comparisons, record NCT04684238-f50963bc. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04684238-f50963bc
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0606 | 0.0168 | 0.196 | wilson | |
| Risk in group 2 | 0.0492 | 0.0169 | 0.135 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0114 | -0.0849 | 0.151 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.23 | 0.217 | 7.01 | log | |
| Odds ratio, group 1 over group 2 | 1.25 | 0.198 | 7.87 | log | |
| Number needed to treat, for one more participant with the outcome on Drug: Midazolam than on Drug: Isoflurane | 87.5 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Drug: Midazolam | Midazolam for sedation in the ICU~Midazolam: Solution for Injection/Infusion | 2 | 33 | OG000 |
| Group 2 | Drug: Isoflurane | Volatile for sedation in the ICU~Isoflurane: Inhalation vapour, liquid. Isoflurane delivered by the AnaConDa-S (Anaesthetic Conserving Device) | 3 | 61 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Evaluate the Number of Patients With Withdrawal Symptom
- Description
- Evaluate the frequency of withdrawal symptoms in isoflurane- vs midazolam-treated patients according to SOS-PD.
- Time frame
- From > 96 hours sedation (including pre-study sedation period) until the end of the 48-hour post study treatment monitoring or ICU discharge, whichever comes first.
- Population
Source ClinicalTrials.gov
Trial
- Title
- Effect & Safety of Inhaled Isoflurane vs IV Midazolam for Sedation in Mechanically Ventilated Children 3-17 Years Old
- NCT number
- NCT04684238
- Phases
- PHASE3
- Conditions
- Sedation
- Interventions
- Midazolam, Isoflurane
- Lead sponsor
- Sedana Medical
- Results first posted
- 2025-05-25
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04684238?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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