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Comparison · NCT04698525-deaths

Valproate Group vs Memantine: deaths from any cause

Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.

2 sourcestrial-comparisons-2026-03-23-0.1.0

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ConductScience Library. Valproate Group vs Memantine: deaths from any cause. Trial comparisons, record NCT04698525-deaths. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04698525-deaths

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Measures6

Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.

MeasureValue95% interval, lower95% interval, upperMethodNote
Risk in group 1000.184wilson
Risk in group 2000.194wilson
Risk difference, group 1 minus group 20-0.1940.184newcombe hybrid score
Risk ratio, group 1 over group 2loga group has no participants with the outcome
Odds ratio, group 1 over group 2loga cell of the two-by-two table is zero
Number needed to harmfrom the risk difference intervalthe two groups' risks are equal

Groups2

Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.

GroupTitleDescriptionWith the outcomeAnalysedClinicalTrials.gov code
Group 1Valproate GroupVPA is a well know antiepileptic drug with multiple side effects. However, in low doses are a few side effects problems.017EG000
Group 2MemantineMemantine is a tolerable drug. However, it is always necessary to ask for side effects in this type o research.016EG001

Harm

What it counts
Total, all-cause mortality
Time frame
Three months of pretreatment (baseline characteristics) Three months, the duration of the study (12 weeks) Three months post-treatment vigilance.

Source ClinicalTrials.gov

Trial

Title
Comparative Study Between Valproate and Memantine in the Prophylactic Management of Episodic Migraine.
NCT number
NCT04698525
Phases
PHASE3
Conditions
Migraine Headache
Interventions
Valproate Sodium, Memantine
Lead sponsor
Universidad Autonoma de San Luis Potosí
Results first posted
2023-05-17

Source ClinicalTrials.gov

Source

Release
trial-comparisons-2026-03-23-0.1.0
Release manifest SHA-256
f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
AACT copy
2026-03-23
Tables read
outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet

Source ClinicalTrials.gov

Sources 2

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ClinicalTrials.govNo license stated
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ClinicalTrials.govnone stated

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.

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