Comparison · NCT04698525-sae
Valproate Group vs Memantine: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Valproate Group vs Memantine: serious adverse events. Trial comparisons, record NCT04698525-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04698525-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.118 | 0.0329 | 0.343 | wilson | |
| Risk in group 2 | 0.0625 | 0.0111 | 0.283 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0551 | -0.181 | 0.287 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.88 | 0.188 | 18.8 | log | |
| Odds ratio, group 1 over group 2 | 2 | 0.163 | 24.5 | log | |
| Number needed to harm, for one more participant with a serious adverse event on Valproate Group than on Memantine | 18.1 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Valproate Group | VPA is a well know antiepileptic drug with multiple side effects. However, in low doses are a few side effects problems. | 2 | 17 | EG000 |
| Group 2 | Memantine | Memantine is a tolerable drug. However, it is always necessary to ask for side effects in this type o research. | 1 | 16 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- Three months of pretreatment (baseline characteristics) Three months, the duration of the study (12 weeks) Three months post-treatment vigilance.
Source ClinicalTrials.gov
Trial
- Title
- Comparative Study Between Valproate and Memantine in the Prophylactic Management of Episodic Migraine.
- NCT number
- NCT04698525
- Phases
- PHASE3
- Conditions
- Migraine Headache
- Interventions
- Valproate Sodium, Memantine
- Lead sponsor
- Universidad Autonoma de San Luis Potosí
- Results first posted
- 2023-05-17
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04698525?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
For software
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