Comparison · NCT05103228-a169d40e
Lower Gonadotropin Dose Stimulation vs Higher Gonadotropin Dose Stimulation: Cumulative Clinical Pregnancy Rate
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Lower Gonadotropin Dose Stimulation vs Higher Gonadotropin Dose Stimulation: Cumulative Clinical Pregnancy Rate. Trial comparisons, record NCT05103228-a169d40e. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT05103228-a169d40e
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.287 | 0.206 | 0.386 | wilson | |
| Risk in group 2 | 0.187 | 0.12 | 0.279 | wilson | |
| Risk difference, group 1 minus group 2 | 0.1 | -0.0227 | 0.219 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.54 | 0.901 | 2.62 | log | |
| Odds ratio, group 1 over group 2 | 1.75 | 0.879 | 3.5 | log | |
| Number needed to treat, for one more participant with the outcome on Lower Gonadotropin Dose Stimulation than on Higher Gonadotropin Dose Stimulation | 9.96 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Lower Gonadotropin Dose Stimulation | Low-dose group:~* 150 IU follitropin alpha + 75 IU highly purified human menopausal gonadotropin (hpHMG)~* 10 mcg follitropin delta + 75 IU hpHMG~Follitropin Alfa: lower dose gonadotropin (follitropin alpha/ follitropin delta + hpHMG) vs. higher dose stimulation (Follitropin alpha/delta + hpHMG)~Follitropin delta: lower dose gonadotropin (follitropin alpha/ follitropin delta + hpHMG) vs. higher dose stimulation (Follitropin alpha/delta + hpHMG)~human menopausal gonadotropin: lower dose gonadotropin (follitropin alpha/ follitropin delta + hpHMG) vs. higher dose stimulation (Follitropin alpha/delta + hpHMG) | 27 | 94 | OG000 |
| Group 2 | Higher Gonadotropin Dose Stimulation | High-dose group:~* 225 IU follitropin alpha + 150 IU highly purified human menopausal gonadotropin (hpHMG)~* 15 mcg follitropin delta + 150 IU hpHMG~Follitropin Alfa: lower dose gonadotropin (follitropin alpha/ follitropin delta + hpHMG) vs. higher dose stimulation (Follitropin alpha/delta + hpHMG)~Follitropin delta: lower dose gonadotropin (follitropin alpha/ follitropin delta + hpHMG) vs. higher dose stimulation (Follitropin alpha/delta + hpHMG)~human menopausal gonadotropin: lower dose gonadotropin (follitropin alpha/ follitropin delta + hpHMG) vs. higher dose stimulation (Follitropin alpha/delta + hpHMG) | 17 | 91 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- Cumulative Clinical Pregnancy Rate
- Description
- an ultrasound confirmation of an intrauterine gestational sac with an embryo with detectable heartbeat in it after the fresh + if available frozen embryo transfer treatments
- Time frame
- 18 months
- Population
- intention to treat
Source ClinicalTrials.gov
Trial
- Title
- Cumulative Pregnancy Rate With Lower and Higher Gonadotropin Dose During IVF Among Poor Responders
- NCT number
- NCT05103228
- Phases
- NA
- Conditions
- Infertility, Ovarian Dysfunction
- Interventions
- Follitropin Alfa, Follitropin delta, human menopausal gonadotropin
- Lead sponsor
- Peter Kovacs MD
- Results first posted
- 2024-12-13
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT05103228?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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