ConductScience.org, home

85,013 comparisons from ClinicalTrials.gov.

85,013 comparisons

Most participants first33,758 with no events in either group come last2,361 to 2,380 of 85,013

Show the results as
ComparisonWith the outcomeRisk difference, 95% intervalParticipantsTrial
Doxorubicin + Cyclophosphamide Followed by Docetaxel (AC -> T) vs Docetaxel + Doxorubicin and Cyclophosphamide (TAC): Death From Any Cause (Overall Survival)187 of 1,649

202 of 1,649

-0.9 points

-3.1 to 1.3

3,298NCT00312208

Docetaxel in Breast Cancer

Group 1 rLP2086 vs Group 2 Saline: serious adverse events33 of 2,471

11 of 822

-0.0 points

-1.1 to 0.8

3,293NCT01352845

A Trial to Assess the Safety, Tolerability, and Immunogenicity of Bivalent rLP2086 Vaccine When Given to Healthy Young Adults Aged >=18 to <26 Years.

Randomized Blinded Phase: LEN + Placebo-to-match (PTM) F/TDF vs Randomized Blinded Phase: Placebo LEN + F/TDF: deaths from any cause4 of 2,195

2 of 1,097

-0.0 points

-0.5 to 0.3

3,292NCT04925752

Pre-Exposure Prophylaxis Study of Lenacapavir in Cisgender Men, Transgender Women, Transgender Men, and Gender Nonbinary People at Risk for HIV Infection

Proton Pump Inhibitor (PPI) vs Normal Saline: Number of Participants With Clinically Important GI Bleeding, Pneumonia, Clostridium Difficile Infection or Acute Myocardial Ischemia360 of 1,644

372 of 1,647

-0.7 points

-3.5 to 2.2

3,291NCT02467621

Stress Ulcer Prophylaxis in the Intensive Care Unit

Proton Pump Inhibitor (PPI) vs Normal Saline: Number of Participants With One or More Infectious Adverse Events276 of 1,644

279 of 1,647

-0.2 points

-2.7 to 2.4

3,291NCT02467621

Stress Ulcer Prophylaxis in the Intensive Care Unit

Proton Pump Inhibitor (PPI) vs Normal Saline: Number of Participants With Clinically Important GI Bleeding41 of 1,644

69 of 1,647

-1.7 points

-3.0 to -0.5

3,291NCT02467621

Stress Ulcer Prophylaxis in the Intensive Care Unit

Proton Pump Inhibitor (PPI) vs Normal Saline: Mortality510 of 1,642

499 of 1,640

0.6 points

-2.5 to 3.8

3,282NCT02467621

Stress Ulcer Prophylaxis in the Intensive Care Unit

Randomized Blinded Phase: LEN + Placebo-to-match (PTM) F/TDF vs Randomized Blinded Phase: Placebo LEN + F/TDF: serious adverse events71 of 2,183

43 of 1,088

-0.7 points

-2.2 to 0.6

3,271NCT04925752

Pre-Exposure Prophylaxis Study of Lenacapavir in Cisgender Men, Transgender Women, Transgender Men, and Gender Nonbinary People at Risk for HIV Infection

Doxorubicin + Cyclophosphamide Followed by Docetaxel (AC -> T) vs Docetaxel + Doxorubicin and Cyclophosphamide (TAC): serious adverse events331 of 1,634

520 of 1,635

-11.5 points

-14.5 to -8.6

3,269NCT00312208

Docetaxel in Breast Cancer

Proton Pump Inhibitor (PPI) vs Normal Saline: deaths from any cause610 of 1,635

601 of 1,626

0.3 points

-3.0 to 3.7

3,261NCT02467621

Stress Ulcer Prophylaxis in the Intensive Care Unit

Proton Pump Inhibitor (PPI) vs Normal Saline: Mortality610 of 1,635

601 of 1,626

0.3 points

-3.0 to 3.7

3,261NCT02467621

Stress Ulcer Prophylaxis in the Intensive Care Unit

Toujeo vs Standard of Care Basal Insulin: deaths from any cause7 of 1,637

4 of 1,621

0.2 points

-0.3 to 0.7

3,258NCT02451137

A "Real World" Trial to Determine Efficacy and Health Outcomes of Toujeo (ACHIEVE CONTROL REAL LIFE STUDY PROGRAM)

Toujeo vs Standard of Care Basal Insulin: serious adverse events161 of 1,637

165 of 1,621

-0.3 points

-2.4 to 1.7

3,258NCT02451137

A "Real World" Trial to Determine Efficacy and Health Outcomes of Toujeo (ACHIEVE CONTROL REAL LIFE STUDY PROGRAM)

Varenicline - With Concomitant Drugs vs Varenicline - Without Concomitant Drugs: Risk Factors for the Frequency of Treatment Related Adverse Events - Concomitant Drugs.289 of 738

424 of 2,519

22.3 points

18.6 to 26.2

3,257NCT00772941

Drug Use Investigation Of Varenicline (Regulatory Post Marketing Commitment Plan)

Varenicline - With Concomitant Therapies vs Varenicline - Without Concomitant Therapies: Risk Factors for the Frequency of Treatment Related Adverse Events - Concomitant Therapies.45 of 101

668 of 3,156

23.4 points

14.0 to 33.2

3,257NCT00772941

Drug Use Investigation Of Varenicline (Regulatory Post Marketing Commitment Plan)

Male vs Female: Risk Factors for the Frequency of Treatment Related Adverse Events - Gender.377 of 2,179

336 of 1,078

-13.9 points

-17.1 to -10.7

3,257NCT00772941

Drug Use Investigation Of Varenicline (Regulatory Post Marketing Commitment Plan)

<65 Years vs >=65 Years: Risk Factors for the Frequency of Treatment Related Adverse Events - Age.571 of 2,768

142 of 489

-8.4 points

-12.8 to -4.3

3,257NCT00772941

Drug Use Investigation Of Varenicline (Regulatory Post Marketing Commitment Plan)

Varenicline - With Chronic Obstructive Pulmonary Disease vs Varenicline - Without Chronic Obstructive Pulmonary Disease: Risk Factors for the Frequency of Treatment Related Adverse Events - Chronic Obstructive Pulmonary Disease as a Complication.23 of 46

690 of 3,211

28.5 points

14.6 to 42.5

3,257NCT00772941

Drug Use Investigation Of Varenicline (Regulatory Post Marketing Commitment Plan)

Standard Practice vs Personal Hand Hygiene Device: Number of Participants With Postoperative Healthcare Acquired Infections108 of 1,620

116 of 1,636

-0.4 points

-2.2 to 1.3

3,256NCT02252562

Hand Hygiene and Hospital Acquired Infections

Standard Practice vs Personal Hand Hygiene Device: Mortality6 of 1,620

7 of 1,636

-0.1 points

-0.6 to 0.4

3,256NCT02252562

Hand Hygiene and Hospital Acquired Infections

Request

GET /api/comparisons/v1

Words from a trial's title, conditions or interventions, its outcome or its groups, or an NCT number.

An outcome counted in participants, the serious adverse events, or the deaths from any cause.

No key needed

Code

Show the call in
curl "https://conductscience.org/api/comparisons/v1?page=119"

Response

The first 2 of this page's 20 results. GET /api/comparisons/v1?page=119

{
  "data": {
    "total": 85013,
    "results": [
      {
        "id": "NCT00312208-f73a5fb6",
        "title": "Doxorubicin + Cyclophosphamide Followed by Docetaxel (AC -> T) vs Docetaxel + Doxorubicin and Cyclophosphamide (TAC): Death From Any Cause (Overall Survival)",
        "summary": "187 of 1649 against 202 of 1649; risk difference -0.9 points, 95% interval -3.1 to 1.3; NCT00312208, Docetaxel in Breast Cancer",
        "record": "/library/comparisons/NCT00312208-f73a5fb6",
        "nct_id": "NCT00312208",
        "kind": "outcome",
        "participants": 3298,
        "risk_difference": {
          "value": -0.009096422073984228,
          "lower": -0.031162673666971907,
          "upper": 0.012958015905097924
        },
        "group_1": "187 of 1,649",
        "group_2": "202 of 1,649",
        "difference": "-0.9 points",
        "interval": "-3.1 to 1.3",
        "trial_title": "Docetaxel in Breast Cancer"
      },
      {
        "id": "NCT01352845-sae",
        "title": "Group 1 rLP2086 vs Group 2 Saline: serious adverse events",
        "summary": "33 of 2471 against 11 of 822; risk difference -0.0 points, 95% interval -1.1 to 0.8; NCT01352845, A Trial to Assess the Safety, Tolerability, and Immunogenicity of Bivalent rLP2086 Vaccine When Given to Healthy Young Adults Aged >=18 to <26 Years.",
        "record": "/library/comparisons/NCT01352845-sae",
        "nct_id": "NCT01352845",
        "kind": "serious-adverse-events",
        "participants": 3293,
        "risk_difference": {
          "value": -0.00002707809618336665,
          "lower": -0.011129155741582934,
          "upper": 0.007926199721466975
        },
        "group_1": "33 of 2,471",
        "group_2": "11 of 822",
        "difference": "-0.0 points",
        "interval": "-1.1 to 0.8",
        "trial_title": "A Trial to Assess the Safety, Tolerability, and Immunogenicity of Bivalent rLP2086 Vaccine When Given to Healthy Young Adults Aged >=18 to <26 Years."
      }
    ],
    "no_events": 33758,
    "columns": [
      {
        "key": "title",
        "label": "Comparison"
      },
      {
        "key": "group_1",
        "label": "With the outcome",
        "under": "group_2"
      },
      {
        "key": "difference",
        "label": "Risk difference, 95% interval",
        "under": "interval"
      },
      {
        "key": "participants",
        "label": "Participants"
      },
      {
        "key": "nct_id",
        "label": "Trial",
        "under": "trial_title"
      }
    ],
    "order": "Most participants first",
    "kinds": {
      "all": 85013,
      "outcome": 33568,
      "serious-adverse-events": 31897,
      "deaths": 19548
    }
  },
  "release": "trial-comparisons-2026-03-23-0.1.0",
  "terms": [
    {
      "source": "ClinicalTrials.gov's posted results, through CTTI's AACT",
      "license": "ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299",
      "notice": "ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.",
      "short": "Freely available. Acknowledgement requested"
    },
    {
      "source": "ClinicalTrials.gov",
      "license": "none stated",
      "notice": "ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.",
      "short": "No license stated"
    }
  ],
  "next": "/api/comparisons/v1?page=120",
  "request_id": "ZVnjFZYhpXXTidcP"
}

Ask about these results. The first 10 go in the prompt.

About this data
Holds
85,013 comparisons
From ClinicalTrials.gov. Counted 10 Nov 2026.
Release
23 Mar 2026
trial-comparisons-2026-03-23-0.1.0
Checked
20 of 20 review comparisons traced to ClinicalTrials.gov, and all 510,078 numbers calculated again apart from the builder agree
Access
Open
No account. 60 calls a minute from one address.

Sources 2

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ClinicalTrials.govNo license stated
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ClinicalTrials.govnone stated

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.

Genes

NCBI Gene

One gene with its proteins, patents, drugs, trials, grants and papers.

Trials

ClinicalTrials.gov

Search clinical trials by condition, drug, outcome or NCT number, with the results each one posted.

Sequences

Patent publications

Paste a sequence and see the patents that disclose it.

Opens sequences.conductscience.org

For software

Read Trial comparisons from software.

Every answer on this page is also JSON, under /api/comparisons/v1. No key.

GET https://conductscience.org/api/comparisons/v1?q=placebo%20heart%20failure&kind=outcome

Ask an assistant

  • In FOURIER, how did serious adverse events compare between evolocumab and placebo?
  • Which metformin trials reported deaths, and what was the risk difference?
  • What was the number needed to treat for HELIOS-B's composite outcome?
  • Which placebo-controlled heart failure trials had the most participants?