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85,013 comparisons from ClinicalTrials.gov. Counted 2026-11-10.
Most participants first33,758 with no events in either group come last221 to 240 of 85,013
| Comparison | With the outcome | Risk difference, 95% interval | Participants | Trial |
|---|---|---|---|---|
| CVnCoV 12 μg Vaccine vs Placebo: Number of Participants Who Experienced a Fatal SAE | 11 of 19,787 12 of 19,753 | -0.0 points -0.1 to 0.0 | 39,540 | NCT04652102 A Phase 2b/3, Randomized, Observer-Blinded, Placebo-Controlled, Multicenter Clinical Study Evaluating the Efficacy and Safety of Investigational SARS-CoV-2 mRNA Vaccine CVnCoV in Adults 18 Years of Age and Older |
| CVnCoV 12 μg Vaccine vs Placebo: deaths from any cause | 17 of 19,787 14 of 19,753 | 0.0 points -0.0 to 0.1 | 39,540 | NCT04652102 A Phase 2b/3, Randomized, Observer-Blinded, Placebo-Controlled, Multicenter Clinical Study Evaluating the Efficacy and Safety of Investigational SARS-CoV-2 mRNA Vaccine CVnCoV in Adults 18 Years of Age and Older |
| CVnCoV 12 μg Vaccine vs Placebo: serious adverse events | 149 of 19,787 111 of 19,753 | 0.2 points 0.0 to 0.4 | 39,540 | NCT04652102 A Phase 2b/3, Randomized, Observer-Blinded, Placebo-Controlled, Multicenter Clinical Study Evaluating the Efficacy and Safety of Investigational SARS-CoV-2 mRNA Vaccine CVnCoV in Adults 18 Years of Age and Older |
| Cases vs Controls: Number of New Onset Skin Cancers in the White Ethnicity Subgroup | 103 of 7,932 563 of 31,118 | -0.5 points -0.8 to -0.2 | 39,050 | NCT04969419 Incidence of Melanoma and Non-melanoma Skin Cancer in People With Vitiligo |
| Double-blind Phase: Ad26.COV2.S 5*10^10 vp vs Double-blind Phase: Placebo: Number of Participants With First Occurrence of Molecularly Confirmed Severe/Critical COVID-19 With Seronegative Status With Onset at Least 14 Days After Double-blind Vaccination on Day 1 (Day 15): Double-blind Phase | 56 of 19,400 205 of 19,398 | -0.8 points -0.9 to -0.6 | 38,798 | NCT04505722 A Study of Ad26.COV2.S for the Prevention of SARS-CoV-2-Mediated COVID-19 in Adult Participants |
| Double-blind Phase: Ad26.COV2.S 5*10^10 vp vs Double-blind Phase: Placebo: Number of Participants With Burden of Disease (BOD) Based on First Occurrence of Molecularly Confirmed Symptomatic COVID-19 (Double Blind Phase) | 495 of 19,400 1,082 of 19,398 | -3.0 points -3.4 to -2.6 | 38,798 | NCT04505722 A Study of Ad26.COV2.S for the Prevention of SARS-CoV-2-Mediated COVID-19 in Adult Participants |
| Double-blind Phase: Ad26.COV2.S 5*10^10 vp vs Double-blind Phase: Placebo: Number of Participants With First Occurrence of Molecularly Confirmed Mild COVID-19 (Double Blind Phase | 11 of 19,400 15 of 19,398 | -0.0 points -0.1 to 0.0 | 38,798 | NCT04505722 A Study of Ad26.COV2.S for the Prevention of SARS-CoV-2-Mediated COVID-19 in Adult Participants |
| Double-blind Phase: Ad26.COV2.S 5*10^10 vp vs Double-blind Phase: Placebo: Number of Participants With First Occurrence of COVID-19 Requiring Medical Intervention (Double Blind Phase) | 18 of 19,400 74 of 19,398 | -0.3 points -0.4 to -0.2 | 38,798 | NCT04505722 A Study of Ad26.COV2.S for the Prevention of SARS-CoV-2-Mediated COVID-19 in Adult Participants |
| Double-blind Phase: Ad26.COV2.S 5*10^10 vp vs Double-blind Phase: Placebo: Number of Participants With First Occurrence of Molecularly Confirmed COVID-19 Defined by the US Food and Drug Administration (FDA) Harmonized Case Definition (Double Blind Phase) | 492 of 19,400 1,067 of 19,398 | -3.0 points -3.4 to -2.6 | 38,798 | NCT04505722 A Study of Ad26.COV2.S for the Prevention of SARS-CoV-2-Mediated COVID-19 in Adult Participants |
| Double-blind Phase: Ad26.COV2.S 5*10^10 vp vs Double-blind Phase: Placebo: Number of Participants With First Occurrence of SARS-CoV-2 Infection (Serologically and/or Molecularly Confirmed) (Double Blind Phase) | 1,038 of 19,113 1,699 of 18,924 | -3.5 points -4.1 to -3.0 | 38,037 | NCT04505722 A Study of Ad26.COV2.S for the Prevention of SARS-CoV-2-Mediated COVID-19 in Adult Participants |
| Double-blind Phase: Ad26.COV2.S 5*10^10 vp vs Double-blind Phase: Placebo: Number of Participants With SARS-CoV-2 Seroconversion Based on Antibodies to N Protein Using ELISA and/or SARS-CoV-2 Immunoglobulin Assay (Double Blind Phase) | 550 of 19,113 724 of 18,924 | -0.9 points -1.3 to -0.6 | 38,037 | NCT04505722 A Study of Ad26.COV2.S for the Prevention of SARS-CoV-2-Mediated COVID-19 in Adult Participants |
| Double-blind Phase: Ad26.COV2.S 5*10^10 vp vs Double-blind Phase: Placebo: Number of Participants With First Occurrence of COVID-19 Requiring Medical Intervention (Double Blind Phase) | 16 of 19,113 64 of 18,924 | -0.3 points -0.4 to -0.2 | 38,037 | NCT04505722 A Study of Ad26.COV2.S for the Prevention of SARS-CoV-2-Mediated COVID-19 in Adult Participants |
| Double-blind Phase: Ad26.COV2.S 5*10^10 vp vs Double-blind Phase: Placebo: Number of Participants With First Occurrence of Molecularly Confirmed Mild COVID-19 (Double Blind Phase) | 10 of 19,113 12 of 18,924 | -0.0 points -0.1 to 0.0 | 38,037 | NCT04505722 A Study of Ad26.COV2.S for the Prevention of SARS-CoV-2-Mediated COVID-19 in Adult Participants |
| Double-blind Phase: Ad26.COV2.S 5*10^10 vp vs Double-blind Phase: Placebo: Number of Participants With First Occurrence of Molecularly Confirmed Severe/Critical COVID-19 With Seronegative Status With Onset at Least 28 Days After Double-blind Vaccination on Day 1 (Day 29): Double-blind Phase | 46 of 19,113 176 of 18,924 | -0.7 points -0.8 to -0.5 | 38,037 | NCT04505722 A Study of Ad26.COV2.S for the Prevention of SARS-CoV-2-Mediated COVID-19 in Adult Participants |
| Double-blind Phase: Ad26.COV2.S 5*10^10 vp vs Double-blind Phase: Placebo: Number of Participants With First Occurrence of Molecularly Confirmed COVID-19 Defined by the US Food and Drug Administration (FDA) Harmonized Case Definition (Double Blind Phase) | 441 of 19,113 884 of 18,924 | -2.4 points -2.7 to -2.0 | 38,037 | NCT04505722 A Study of Ad26.COV2.S for the Prevention of SARS-CoV-2-Mediated COVID-19 in Adult Participants |
| Double-blind Phase: Ad26.COV2.S 5*10^10 vp vs Double-blind Phase: Placebo: Number of Participants With BOD Based on First Occurrence of Molecularly Confirmed Symptomatic COVID-19 (Double Blind Phase) | 443 of 19,113 895 of 18,924 | -2.4 points -2.8 to -2.0 | 38,037 | NCT04505722 A Study of Ad26.COV2.S for the Prevention of SARS-CoV-2-Mediated COVID-19 in Adult Participants |
| Double-blind Phase: Ad26.COV2.S 5*10^10 vp vs Double-blind Phase: Placebo: Number of Participants With Asymptomatic Infection Detected by RT-PCR at the Time of the Month 6/Unblinding Visit (Double Blind Phase) | 10 of 19,113 12 of 18,924 | -0.0 points -0.1 to 0.0 | 38,037 | NCT04505722 A Study of Ad26.COV2.S for the Prevention of SARS-CoV-2-Mediated COVID-19 in Adult Participants |
| Cases vs Controls: Number of New Onset Skin Cancers in the Most Deprived Subgroup | 46 of 7,681 345 of 30,325 | -0.5 points -0.7 to -0.3 | 38,006 | NCT04969419 Incidence of Melanoma and Non-melanoma Skin Cancer in People With Vitiligo |
| Chlorhexidine Cord Care vs Dry Cord Care: deaths from any cause | 282 of 18,510 263 of 19,346 | 0.2 points -0.1 to 0.4 | 37,856 | NCT01241318 Zambia Chlorhexidine Application Trial |
| People With Crohn's Disease (Cases) vs People Without Crohn's Disease (Controls): Prevalence of Depressive Episodes (Crohn's Disease) | 431 of 7,557 1,233 of 30,228 | 1.6 points 1.1 to 2.2 | 37,785 | NCT03836612 Healthcare Resource Utilisation, Common Mental Health Problems, and Infections in People With Inflammatory Bowel Disease |
Response
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NCBI Gene
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Search clinical trials by condition, drug, outcome or NCT number, with the results each one posted.
Patent publications
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For software
Every answer on this page is also JSON, under /api/comparisons/v1. No key.
GET https://conductscience.org/api/comparisons/v1?q=placebo%20heart%20failure&kind=outcome
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