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85,013 comparisons from ClinicalTrials.gov. Counted 2026-11-10.
Most participants first33,758 with no events in either group come last1,561 to 1,580 of 85,013
| Comparison | With the outcome | Risk difference, 95% interval | Participants | Trial |
|---|---|---|---|---|
| Palbociclib Plus Endocrine Therapy (Arm A) vs Endocrine Therapy Alone (Arm B): deaths from any cause | 99 of 2,841 76 of 2,902 | 0.9 points -0.0 to 1.8 | 5,743 | NCT02513394 PALbociclib CoLlaborative Adjuvant Study |
| Palbociclib Plus Endocrine Therapy (Arm A) vs Endocrine Therapy Alone (Arm B): serious adverse events | 369 of 2,841 229 of 2,902 | 5.1 points 3.5 to 6.7 | 5,743 | NCT02513394 PALbociclib CoLlaborative Adjuvant Study |
| Telmisartan (TRANSCEND) vs Placebo (TRANSCEND): TRANSCEND. New Onset of Atrial Fibrillation | 181 of 2,851 182 of 2,870 | 0.0 points -1.3 to 1.3 | 5,721 | NCT00153101 Effectiveness and Safety of Ramipril Alone Compared With Telmisartan Alone and in Combination With Ramipril in Patients at High Risk for Cardiovascular Events. Patients Intolerant to Ramipril Were Entered in TRANSCEND, Telmisartan Compared to Placebo. |
| Group 1: rLP2086 vs Group 2: HAV/Saline/HAV: serious adverse events | 59 of 3,796 48 of 1,908 | -1.0 points -1.8 to -0.2 | 5,704 | NCT01352793 A Global Phase 3 Safety Study of 120 mcg rLP2086 Vaccine in Adolescents and Young Adults Aged 10 to 25 Years |
| QIVc vs Comparator: deaths from any cause | 1 of 2,856 2 of 2,841 | -0.0 points -0.2 to 0.1 | 5,697 | NCT03932682 Efficacy Study With QIVc in Pediatric Subjects |
| QIVc vs Comparator: serious adverse events | 64 of 2,856 84 of 2,841 | -0.7 points -1.6 to 0.1 | 5,697 | NCT03932682 Efficacy Study With QIVc in Pediatric Subjects |
| All TNFi Initiators Combination vs All TNFI Initiators Monotherapy: Number of Participants With mACR20 at 6 Months for TNFi Monotherapy vs TNFi Combination With MTX | 1,224 of 4,013 394 of 1,683 | 7.1 points 4.6 to 9.5 | 5,696 | NCT05576051 To Estimate the Efficacy of Treatment With TNFi as Monotherapy or Combination Therapy With MTX and Compare and Contrast Efficacy With Tofacitinib as Monotherapy and Combination Therapy in a Real World Setting. |
| Adherence Intervention vs Usual Care: deaths from any cause | 28 of 2,879 24 of 2,808 | 0.1 points -0.4 to 0.6 | 5,687 | NCT03748420 Medication Adherence Clinical Decision Support |
| Adherence Intervention vs Usual Care: serious adverse events | 559 of 2,879 557 of 2,808 | -0.4 points -2.5 to 1.6 | 5,687 | NCT03748420 Medication Adherence Clinical Decision Support |
| Finerenone vs Placebo: All-cause Mortality | 219 of 2,833 244 of 2,841 | -0.9 points -2.3 to 0.6 | 5,674 | NCT02540993 Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and Diabetic Kidney Disease |
| Finerenone vs Placebo: The First Occurrence of the Composite Endpoint of Onset of Kidney Failure, a Sustained Decrease of eGFR ≥40% From Baseline Over at Least 4 Weeks, or Renal Death | 504 of 2,833 600 of 2,841 | -3.3 points -5.4 to -1.3 | 5,674 | NCT02540993 Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and Diabetic Kidney Disease |
| Finerenone vs Placebo: The First Occurrence of the Composite Endpoint of Cardiovascular Death, Non-fatal Myocardial Infarction, Non-fatal Stroke, or Hospitalization for Heart Failure | 367 of 2,833 420 of 2,841 | -1.8 points -3.6 to -0.0 | 5,674 | NCT02540993 Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and Diabetic Kidney Disease |
| Finerenone vs Placebo: All-cause Hospitalization | 1,263 of 2,833 1,321 of 2,841 | -1.9 points -4.5 to 0.7 | 5,674 | NCT02540993 Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and Diabetic Kidney Disease |
| Finerenone vs Placebo: The First Occurrence of the Composite Endpoint of Onset of Kidney Failure, a Sustained Decrease in eGFR of ≥57% From Baseline Over at Least 4 Weeks, or Renal Death | 252 of 2,833 326 of 2,841 | -2.6 points -4.2 to -1.0 | 5,674 | NCT02540993 Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and Diabetic Kidney Disease |
| Finerenone vs Placebo: deaths from any cause | 222 of 2,833 250 of 2,841 | -1.0 points -2.4 to 0.5 | 5,674 | NCT02540993 Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and Diabetic Kidney Disease |
| LCZ696 (Sacubitril/Valsartan) vs Ramipril: Number of Participants With a Confirmed Composite of HF Hospitalization or Outpatient HF | 201 of 2,830 237 of 2,831 | -1.3 points -2.7 to 0.1 | 5,661 | NCT02924727 Prospective ARNI vs ACE Inhibitor Trial to DetermIne Superiority in Reducing Heart Failure Events After MI |
| LCZ696 (Sacubitril/Valsartan) vs Ramipril: Number of Participants With a Confirmed Composite of CV Death or HF Hospitalization | 308 of 2,830 335 of 2,831 | -0.9 points -2.6 to 0.7 | 5,661 | NCT02924727 Prospective ARNI vs ACE Inhibitor Trial to DetermIne Superiority in Reducing Heart Failure Events After MI |
| LCZ696 (Sacubitril/Valsartan) vs Ramipril: All-cause Mortality for Full Analysis Set (FAS) | 213 of 2,830 242 of 2,831 | -1.0 points -2.4 to 0.4 | 5,661 | NCT02924727 Prospective ARNI vs ACE Inhibitor Trial to DetermIne Superiority in Reducing Heart Failure Events After MI |
| LCZ696 (Sacubitril/Valsartan) vs Ramipril: Number of Participants With a Confirmed Composite of CV Death, Non-fatal Spontaneous Myocardial Infarction or Non-fatal Stroke | 315 of 2,830 349 of 2,831 | -1.2 points -2.9 to 0.5 | 5,661 | NCT02924727 Prospective ARNI vs ACE Inhibitor Trial to DetermIne Superiority in Reducing Heart Failure Events After MI |
| Finerenone vs Placebo: serious adverse events | 902 of 2,827 971 of 2,831 | -2.4 points -4.8 to 0.1 | 5,658 | NCT02540993 Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and Diabetic Kidney Disease |
Response
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NCBI Gene
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Every answer on this page is also JSON, under /api/comparisons/v1. No key.
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