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Drug · CHEMBL104

CLOTRIMAZOLE

7 sourcespipelines-2026-09-18-0.3.1

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ConductScience Library. CLOTRIMAZOLE. Drugs and targets, record CHEMBL104. Release pipelines-2026-09-18-0.3.1, 18 Sept 2026. https://conductscience.org/library/drugs/CHEMBL104

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Drug

Names and IDs as ChEMBL gives them, through Open Targets.

Name
CLOTRIMAZOLE
ChEMBL
ChEMBL ID
CHEMBL104
ChEMBL
Type
Small molecule
ChEMBL
Brand names
Abtrim, Actavall, Candiden, Canesten, Canesten af, Canesten crm combi, Canesten internal, Canesten vc, Clotrimazole component of lotrisone, Fungederm, Gyne-lotrimin, Gyne-lotrimin 3, Gyne-lotrimin 3 combination pack, Gyne-lotrimin combination pack, Gynix, Masnoderm, Mycelex, Mycelex-7, Mycelex-7 combination pack, Mycelex-g, Mycil gold, Privacom, Trimysten, Trivagizole 3
ChEMBL
Other names
BAY 5097, BAY-5097, Clotrimazol, GNF-PF-3499, Lotrimin, NSC-257473, SVT-15652, Svt-15652, Trivagizole
ChEMBL
DrugBank
DB00257
DrugBank
InChIKey
VNFPBHJOKIVQEB-UHFFFAOYSA-N
ChEMBL
Open Targets' highest stage
Approval, for 7 of its 19 diseases, from ATC and DailyMed
Open Targets

Targets0

The targets ChEMBL's mechanism records give for the drug, through Open Targets. A mechanism record says what the drug acts on, not how strongly.

None in this release.

Diseases19

The diseases Open Targets' clinical reports study the drug for, the most trial reports first. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

DiseaseOpen Targets' stageStage reported byReportsOf them trialsIts drugs
vulvovaginal candidiasisPhase 3ClinicalTrials.gov66https://conductscience.org/library/drugs?q=MONDO_0006014
otomycosisPhase 3ClinicalTrials.gov55https://conductscience.org/library/drugs?q=MONDO_0000262
tinea pedisApprovalDailyMed72https://conductscience.org/library/drugs?q=MONDO_0005984
sickle cell diseasePhase 1/2ClinicalTrials.gov22https://conductscience.org/library/drugs?q=MONDO_0011382
acnePhase 2/3ClinicalTrials.gov11https://conductscience.org/library/drugs?q=MONDO_0011438
bacterial vaginosisPhase 3ClinicalTrials.gov11https://conductscience.org/library/drugs?q=MONDO_0005316
oral candidiasisPhase 2ClinicalTrials.gov11https://conductscience.org/library/drugs?q=MONDO_0005886
oral lichen planusPhase 2ClinicalTrials.gov11https://conductscience.org/library/drugs?q=EFO_0008517
pityriasis versicolorPhase 1/2ClinicalTrials.gov11https://conductscience.org/library/drugs?q=MONDO_0005915
pouchitisPhase 1/2ClinicalTrials.gov11https://conductscience.org/library/drugs?q=MONDO_0005312

Trials38

Trials whose record names the drug by a name ChEMBL states, posted results first, then the largest. Open Targets read each trial's text to find its drugs.

TrialTitlePhaseParticipantsResults first postedNamed asLinked bySource
NCT02180828Clotrimazole Vaginal Tablet vs Fluconazole for Severe Vulvovaginal CandidiasisPhase 42402016-09-30clotrimazoleIts nameClinicalTrials.gov
NCT03686384SVT-15652 Otic Solution for the Treatment of OtomycosisPhase 32172023-01-18SVT-15652Its nameClinicalTrials.gov
NCT03686397SVT-15652 Otic Solution for the Treatment of Otomycosis.Phase 31942022-12-15svt-15652Its nameClinicalTrials.gov
NCT01993823Clinical Study to Assess the Efficacy and Safety of G238 Compared to Clotrimazole Otic Solution in the Treatment of OtomycosisPhase 31902017-02-13clotrimazoleIts nameClinicalTrials.gov
NCT00671528Safety and Efficacy of Quadriderme® in the Treatment of Impetiginous Eczema (Study P05134AM4)Phase 432011-06-16clotrimazoleIts nameClinicalTrials.gov
NCT06349122AUTOP 2: Screen-and-treat Strategy for Vaginal Flora Abnormalities by Molecular Biology in Pregnant Women at High Risk of Preterm BirthPhase 31,794clotrimazoleIts nameClinicalTrials.gov
NCT00000676
Randomized Comparative Study of Fluconazole Versus Clotrimazole Troches in the Prevention of Serious Fungal Infection in Patients With AIDS or Advanced AIDS-Related Complex. (A Nested Study of ACTG 081)
Phase 3500clotrimazoleIts nameClinicalTrials.gov
NCT00755053Comparative Efficacy of Ovule vs TabletPhase 3466clotrimazoleIts nameClinicalTrials.gov
NCT07441005Comparative Efficacy of Topical Oxiconazole Cream (1%) Versus Topical Clotrimazole Cream (1%) in the Treatment of Tinea CrurisAbstractEarly phase 1386clotrimazoleIts nameClinicalTrials.gov
NCT02635438
A Comparative Clinical Trial to Evaluate the Safety and Clinical Equivalence of Clotrimazole Troche/Lozenges USP, 10mg (Unique Pharmaceutical Laboratories, India) With Clotrimazole Troche 10mg (Roxane Laboratories Inc., USA) in Subjects With Oropharyngeal Candidiasis.
Phase 3360clotrimazoleIts nameClinicalTrials.gov

1 to 10 of 38

See all 38 trials

Comparisons in its trials17

Comparisons Trial comparisons calculated in the trials whose record names the drug, most participants first. A comparison in one of its trials does not always compare the drug, so read the two groups.

ComparisonGroup 1, with the outcomeGroup 2, with the outcomeParticipantsTrialSource
Clotrimazole Vaginal Tablet vs Fluconazole: Adverse Events 33 of 1153 of 113228NCT02180828Trial comparisons
Clotrimazole Vaginal Tablet vs Fluconazole: Adverse Events 40 of 1153 of 113228NCT02180828Trial comparisons
Clotrimazole Vaginal Tablet vs Fluconazole: Total Adverse Events16 of 11512 of 113228NCT02180828Trial comparisons
Clotrimazole Vaginal Tablet vs Fluconazole: Adverse Events 212 of 1151 of 113228NCT02180828Trial comparisons
Clotrimazole Vaginal Tablet vs Fluconazole: Adverse Events 11 of 1159 of 113228NCT02180828Trial comparisons
Clotrimazole Vaginal Tablet vs Fluconazole: serious adverse events0 of 1150 of 113228NCT02180828Trial comparisons
Clotrimazole Vaginal Tablet vs Fluconazole: Therapeutic Efficacy 390 of 11581 of 110225NCT02180828Trial comparisons
Clotrimazole Vaginal Tablet vs Fluconazole: Therapeutic Efficacy 1102 of 11498 of 110224NCT02180828Trial comparisons
Clotrimazole Vaginal Tablet vs Fluconazole: Therapeutic Efficacy 282 of 11485 of 109223NCT02180828Trial comparisons
Clotrimazole Vaginal Tablet vs Fluconazole: Therapeutic Efficacy 462 of 11461 of 109223NCT02180828Trial comparisons

Papers from its trials4

The papers the trials whose record names the drug list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMIDListed asTrials listing itSource
36532230RESULT1PubMed
27073145RESULT1PubMed
34033120DERIVED1PubMed
32940765DERIVED1PubMed

Tests in its trials0

The tests ConductCognition runs that the trials whose record names the drug name in their registered outcomes, as ScienceGraph matched them. ConductCognition's list names the tests it runs, not every test a trial used.

None in this release.

Data dates

The date of each source this release read.

Open Targets
2026-09-18
Open Targets
ClinicalTrials.gov
2026-11-05
ClinicalTrials.gov
Results, from AACT
2026-03-23
AACT
Papers the trials list, from Trials
2026-11-12
Trials
Comparisons, from Trial comparisons
2026-03-23
Trial comparisons
Tests named in the trials, as ScienceGraph matched them
2026-11-12
ConductCognition

Sources 7

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ConductCognition's list of its testsOur own data
  • ClinicalTrials.govNo license stated
  • NLM's MeSHNLM's terms
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ConductCognition's list of its testsOur own data: ConductCognition's list of its tests, https://conductcognition.com
  • ClinicalTrials.govnone stated
  • NLM's MeSHNLM's
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this drug from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/drugs/v1/CHEMBL104

GET https://conductscience.org/api/drugs/v1/CHEMBL104/trials?page=2