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ADA: adenosine deaminase

1 protein, 52 patents, 3 drugs, 48 trials, 5,436 NIH grants and 16,711 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolADAHGNC
Nameadenosine deaminaseHGNC
NCBI Gene ID100NCBI Gene
HGNC IDHGNC:186HGNC
EnsemblENSG00000196839NCBI Gene
AliasesADA1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P00813Adenosine deaminase3632Ensembl, GeneID, HGNCUniProt

Patents 52

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21357P00813Espacenet
EP 4720289 A12026-04-08229P00813Espacenet
JP 2026004568 A2026-01-1436632P00813Espacenet
EP 4650780 A22025-11-199194P00813Espacenet
EP 4641202 A22025-10-295564P00813Espacenet
JP 2025534660 A2025-10-174P00813Espacenet
EP 4608979 A12025-09-03898P00813Espacenet
EP 4601672 A12025-08-204P00813Espacenet
KR 1020250087665 A2025-06-164P00813Espacenet
JP 2025517970 A2025-06-129194P00813Espacenet

Drugs 3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AUTOLOGOUS CD34+ ENRICHED CELL FRACTION THAT CONTAINS CD34+ CELLS TRANSDUCED WITH RETROVIRAL VECTOR THAT ENCODES FOR THE HUMAN ADA CDNA SEQUENCECHEMBL5315093ADA exogenous geneEXOGENOUS GENEChEMBL
COFORMYCINCHEMBL284483Adenosine deaminase inhibitorINHIBITORChEMBL
PENTOSTATINCHEMBL1580Adenosine deaminase inhibitorINHIBITORChEMBL

Trials 48

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05757310PENTOSTATINPHASE1ClinicalTrials.gov
NCT04176380PENTOSTATINPHASE2ClinicalTrials.gov
NCT03922724PENTOSTATINPHASE2ClinicalTrials.gov
NCT03448393PENTOSTATINPHASE12025-06-04ClinicalTrials.gov
NCT03249831PENTOSTATINPHASE1ClinicalTrials.gov
NCT03232203AUTOLOGOUS CD34+ ENRICHED CELL FRACTION THAT CONTAINS CD34+ CELLS TRANSDUCED WITH RETROVIRAL VECTOR THAT ENCODES FOR THE HUMAN ADA CDNA SEQUENCEClinicalTrials.gov
NCT03112603PENTOSTATINPHASE32022-04-15ClinicalTrials.gov
NCT03077542PENTOSTATINPHASE1/PHASE22024-08-07ClinicalTrials.gov
NCT02579967PENTOSTATINPHASE2ClinicalTrials.gov
NCT02105766PENTOSTATINPHASE22024-11-29ClinicalTrials.gov

NIH grants 5436

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
ZIADK031117Development of Drugs Acting at Adenosine Receptors452,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program262,025NIH's project files
P30CA008748Cancer Center Support Grant252,025NIH's project files
P30CA016672Cancer Center Support Grant232,025NIH's project files
ZIAHG200372Genetics, Pathophysiology, and Treatment of Autoinflammatory and Autoimmune Diseases222,025NIH's project files
P30CA016058Cancer Center Support Grant172,025NIH's project files
R13AI094943Annual Primary Immune Deficiency Treatment Consortium (PIDTC) Workshop and Education Day172,025NIH's project files
P30CA042014Cancer Center Support Grant152,025NIH's project files
P30AI050409Center for AIDS Research at Emory University132,025NIH's project files
ZIAAI001222Characterization of the cellular and molecular bases of inborn errors of immunity122,025NIH's project files

Papers 16711

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42821800PubTator, text miningPubMed
42801209PubTator, text miningPubMed
42800825PubTator, text miningPubMed
42794664PubTator, text miningPubMed
42791507PubTator, text miningPubMed
42791403PubTator, text miningPubMed
42783220PubTator, text miningPubMed
42774687PubTator, text miningPubMed
42762596PubTator, text miningPubMed
42751665PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license