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AKT3: AKT serine/threonine kinase 3

1 protein, 147 patents, 14 drugs, 175 trials, 3,437 NIH grants and 5,980 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolAKT3HGNC
NameAKT serine/threonine kinase 3HGNC
NCBI Gene ID10000NCBI Gene
HGNC IDHGNC:393HGNC
EnsemblENSG00000117020NCBI Gene
AliasesMPPH, MPPH2, PKB-GAMMA, PKBG, PRKBG, RAC-PK-gamma, RAC-gamma, STK-2NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q9Y243RAC-gamma serine/threonine-protein kinase4792Ensembl, GeneID, HGNCUniProt

Patents 147

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026090326 A2026-06-022Q9Y243Espacenet
US 12616690 B22026-05-052Q9Y243Espacenet
JP 2026027231 A2026-02-182Q9Y243Espacenet
JP 2026004302 A2026-01-142Q9Y243Espacenet
EP 4653429 A12025-11-262Q9Y243Espacenet
EP 4650780 A22025-11-192257Q9Y243Espacenet
EP 4641201 A22025-10-291829Q9Y243Espacenet
JP 2025517969 A2025-06-121829Q9Y243Espacenet
JP 2025517970 A2025-06-122257Q9Y243Espacenet
EP 4484957 A12025-01-01185Q9Y243Espacenet

Drugs 14

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AFURESERTIBCHEMBL2219422Serine/threonine-protein kinase AKT inhibitorINHIBITORChEMBL
CAPIVASERTIBCHEMBL2325741Serine/threonine-protein kinase AKT inhibitorINHIBITORChEMBL
GSK-690693CHEMBL494089Serine/threonine-protein kinase AKT inhibitorINHIBITORChEMBL
IPATASERTIBCHEMBL2177390Serine/threonine-protein kinase AKT inhibitorINHIBITORChEMBL
LY-2780301CHEMBL3545134Serine/threonine-protein kinase AKT inhibitorINHIBITORChEMBL
MIRANSERTIBCHEMBL4297188Serine/threonine-protein kinase AKT inhibitorINHIBITORChEMBL
MK-2201CHEMBL3545000Serine/threonine-protein kinase AKT inhibitorINHIBITORChEMBL
MK-2206CHEMBL1079175Serine/threonine-protein kinase AKT inhibitorINHIBITORChEMBL
PIFUSERTIBCHEMBL4297329Serine/threonine-protein kinase AKT negative allosteric modulatorNEGATIVE ALLOSTERIC MODULATORChEMBL
RUPITASERTIBCHEMBL4871106Serine/threonine-protein kinase AKT3 inhibitorINHIBITORChEMBL

Trials 175

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07486648CAPIVASERTIBPHASE1/PHASE2ClinicalTrials.gov
NCT07426822CAPIVASERTIBPHASE2ClinicalTrials.gov
NCT07294677CAPIVASERTIBPHASE1/PHASE2ClinicalTrials.gov
NCT07281833CAPIVASERTIBPHASE3ClinicalTrials.gov
NCT07175415CAPIVASERTIBPHASE1/PHASE2ClinicalTrials.gov
NCT06837792CAPIVASERTIBPHASE2ClinicalTrials.gov
NCT06764186CAPIVASERTIBPHASE3ClinicalTrials.gov
NCT06635447CAPIVASERTIBPHASE3ClinicalTrials.gov
NCT06613516CAPIVASERTIBPHASE2ClinicalTrials.gov
NCT06607757CAPIVASERTIBPHASE2ClinicalTrials.gov

NIH grants 3437

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant862,025NIH's project files
P30CA008748Cancer Center Support Grant542,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant182,025NIH's project files
R01NS058721ACC: Callosal Agenesis as a Window into Common Neurodevelopmental Disorders112,025NIH's project files
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes102,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant102,025NIH's project files
P30CA068485Cancer Center Support Grant102,025NIH's project files
P30CA091842Cancer Center Support Grant102,025NIH's project files
P50CA058223SPORE in Breast Cancer102,025NIH's project files
P30CA016058Cancer Center Support Grant92,025NIH's project files

Papers 5980

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42814223PubTator, text miningPubMed
42808171PubTator, text miningPubMed
42797522PubTator, text miningPubMed
42770621PubTator, text miningPubMed
42758762PubTator, text miningPubMed
42721895PubTator, text miningPubMed
42704227PubTator, text miningPubMed
42697596PubTator, text miningPubMed
42690532PubTator, text miningPubMed
42658765PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license