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HDAC6: histone deacetylase 6

1 protein, 51 patents, 14 drugs, 648 trials, 3,707 NIH grants and 8,051 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolHDAC6HGNC
Namehistone deacetylase 6HGNC
NCBI Gene ID10013NCBI Gene
HGNC IDHGNC:14064HGNC
EnsemblENSG00000094631NCBI Gene
AliasesCPBHM, FLJ16239, HD6, JM21, KDAC6, KIAA0901, PPP1R90NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q9UBN7Protein deacetylase HDAC61,21521Ensembl, GeneID, HGNCUniProt

Patents 51

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-295805Q9UBN7Espacenet
JP 2025517969 A2025-06-125805Q9UBN7Espacenet
JP 2025024198 A2025-02-1912985Q9UBN7Espacenet
JP 2024123008 A2024-09-106470Q9UBN7Espacenet
JP 2024123008 A2024-09-106472Q9UBN7Espacenet
US 12023385 B22024-07-0240Q9UBN7Espacenet
JP 2023123507 A2023-09-05337Q9UBN7Espacenet
EP 4119552 A12023-01-1854Q9UBN7Espacenet
US 11446398 B22022-09-2038608Q9UBN7Espacenet
US 11446398 B22022-09-2038610Q9UBN7Espacenet

Drugs 14

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABEXINOSTATCHEMBL2103863Histone deacetylase inhibitorINHIBITORChEMBL
BELINOSTATCHEMBL408513Histone deacetylase inhibitorINHIBITORChEMBL
CUDC-101CHEMBL598797Histone deacetylase inhibitorINHIBITORChEMBL
ENTINOSTATCHEMBL27759Histone deacetylase inhibitorINHIBITORChEMBL
FIMEPINOSTATCHEMBL3622533Histone deacetylase inhibitorINHIBITORChEMBL
GIVINOSTATCHEMBL1213492Histone deacetylase inhibitorINHIBITORChEMBL
GIVINOSTAT HYDROCHLORIDECHEMBL6068400Histone deacetylase inhibitorINHIBITORChEMBL
PANOBINOSTATCHEMBL483254Histone deacetylase inhibitorINHIBITORChEMBL
PANOBINOSTAT LACTATECHEMBL3545368Histone deacetylase inhibitorINHIBITORChEMBL
QUISINOSTATCHEMBL2105763Histone deacetylase inhibitorINHIBITORChEMBL

Trials 648

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07492394ENTINOSTATPHASE2ClinicalTrials.gov
NCT07441486ENTINOSTATPHASE2ClinicalTrials.gov
NCT07330544ENTINOSTATPHASE2ClinicalTrials.gov
NCT07261592ENTINOSTATPHASE1/PHASE2ClinicalTrials.gov
NCT07261241VORINOSTATPHASE2ClinicalTrials.gov
NCT07235618ENTINOSTATPHASE2ClinicalTrials.gov
NCT07217379VORINOSTATPHASE1ClinicalTrials.gov
NCT07150026VORINOSTATPHASE1ClinicalTrials.gov
NCT07150013VORINOSTATPHASE1ClinicalTrials.gov
NCT06995521VORINOSTATPHASE2ClinicalTrials.gov

NIH grants 3707

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant492,025NIH's project files
R01GM049758Structure and Function of Metalloenzymes392,025NIH's project files
P30CA008748Cancer Center Support Grant242,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant222,025NIH's project files
P01CA155258Integrative Oncogenomics of Multiple Myeloma172,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase152,025NIH's project files
P30CA022453CANCER CENTER SUPPORT GRANT152,025NIH's project files
P30CA016058Cancer Center Support Grant142,025NIH's project files
P30DK084567Mayo Center for Cell Signaling in Gastroenterology142,025NIH's project files
P30GM124165NE-CAT: A Resource for Advanced Macromolecular Crystallography122,025NIH's project files

Papers 8051

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42825379PubTator, text miningPubMed
42806692PubTator, text miningPubMed
42805446PubTator, text miningPubMed
42800527PubTator, text miningPubMed
42798205PubTator, text miningPubMed
42794636PubTator, text miningPubMed
42794564PubTator, text miningPubMed
42789724PubTator, text miningPubMed
42788080PubTator, text miningPubMed
42769600PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license