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Gene · 100132285

KIR2DS2: killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KIR2DS2: killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2. Genes, record 100132285. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/100132285

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Gene

Symbol
KIR2DS2
HGNC
Name
killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2
HGNC
NCBI Gene ID
100132285
NCBI Gene
HGNC ID
HGNC:6334
HGNC
Aliases
183ActI, CD158J, CD158b, KIR-2DS2, NKAT-5, NKAT5, cl-49, nkat5
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P43631Killer cell immunoglobulin-like receptor 2DS23043GeneID, HGNC

Source UniProt

Patents77

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2025081298 A2025-05-27343P43631Espacenet
KR 1020250067191 A2025-05-14343P43631Espacenet
JP 2025024198 A2025-02-1913244P43631Espacenet
JP 2025024198 A2025-02-1913245P43631Espacenet
JP 2024528077 A2024-07-2612P43631Espacenet
EP 4378952 A12024-06-0512P43631Espacenet
US 11981731 B22024-05-14343P43631Espacenet
KR 1020240042483 A2024-04-0212P43631Espacenet
US 11919946 B22024-03-0553P43631Espacenet
JP 2024504875 A2024-02-0112P43631Espacenet

1 to 10 of 77

See all 77 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants667

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKIR2DS2 papersNewest fiscal year
P01CA065493Off-the-Shelf Immune Effector Cells for Hematological Malignancies242025
P01CA111412NK cells, their receptors and cancer therapy212025
P30CA008748Cancer Center Support Grant132025
U01AI069197Hematopoietic Stem Cell And Cord Blood Transplantation122025
U01AI090905Insights Into Immune-Related Diseases Born from Population Genomics112025
R01AI128775Integrated Exchange and Storage of Current- and Future-Generation Immunogenomic Data102025
P30CA077598Cancer Center Support Grant92025
U24CA076518A Data Resource for Blood and Marrow Transplants and Adoptive Cellular Therapy Research82025
P30CA021765Cancer Center Support Grant (CCSG)72025
P30CA051008Georgetown University Lombardi Comprehensive Cancer Center Support Grant72025

1 to 10 of 667Source NIH's project files

See all 667 nih grants

Papers1,311

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Beta-Glucan Supplementation Improves Clinical Outcomes and Preserves Immune Homeostasis in Patients with Advanced Solid Tumors Receiving Chemotherapy: A Prospective Phase II Randomized Three-Arm Clinical Trial.
Int J Mol Sci202642653193PubTator, text miningPubMed
Cytotoxic CD4+ T cells: origin, biological functions, diseases and therapeutic targets.Signal Transduct Target Ther202641803090PubTator, text miningPubMed
Integrative Roles of NK Receptors and γδ TCRs in γδ T Cell-Mediated Cancer Immunity.Immune Netw202641800030PubTator, text miningPubMed
Mechanisms of tumor cell evasion from NK cell-mediated killing and advances in NK cell-based cancer immunotherapy.Pharm Sci Adv202641799416PubTator, text miningPubMed
Development and evaluation of an inhalable nanoemulsion system for enhancing NK cell function against osteosarcoma pulmonary metastases.Front Immunol202641766883PubTator, text miningPubMed
MicroRNA-mediated regulation of natural killer cells development, effector functions, and antitumor responses.Cancer Cell Int202541331607PubTator, text miningPubMed
IL-21-reprogrammed Vδ1 T cells exert killing against solid tumors which is enhanced by CAR arming for off-the-shelf immunotherapy.Oncoimmunology202540996786PubTator, text miningPubMed
Allele Level Sequencing of Killer Cell Immunoglobulin-Like Receptor Genes Using Oxford Nanopore Long Read Sequencing.HLA202540985045PubTator, text miningPubMed
Profiling associations of interactive ligand-receptors (HLA class I and KIR gene products) with the progression to type 1 diabetes among seroconverted participants.Diabetologia202540835749PubTator, text miningPubMed
Genomic and immunogenomic profiling of extramedullary acute myeloid leukemia reveals actionable clonal branching and frequent immune editing.Blood Cancer J202540804254PubTator, text miningPubMed

1 to 10 of 1,311

See all 1,311 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

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