Gene · 100132285
KIR2DS2: killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. KIR2DS2: killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2. Genes, record 100132285. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/100132285
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P43631 | Killer cell immunoglobulin-like receptor 2DS2 | 304 | 3 | GeneID, HGNC |
Source UniProt
Patents77
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2025081298 A | 2025-05-27 | 343 | P43631 | Espacenet |
| KR 1020250067191 A | 2025-05-14 | 343 | P43631 | Espacenet |
| JP 2025024198 A | 2025-02-19 | 13244 | P43631 | Espacenet |
| JP 2025024198 A | 2025-02-19 | 13245 | P43631 | Espacenet |
| JP 2024528077 A | 2024-07-26 | 12 | P43631 | Espacenet |
| EP 4378952 A1 | 2024-06-05 | 12 | P43631 | Espacenet |
| US 11981731 B2 | 2024-05-14 | 343 | P43631 | Espacenet |
| KR 1020240042483 A | 2024-04-02 | 12 | P43631 | Espacenet |
| US 11919946 B2 | 2024-03-05 | 53 | P43631 | Espacenet |
| JP 2024504875 A | 2024-02-01 | 12 | P43631 | Espacenet |
1 to 10 of 77
See all 77 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants667
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | KIR2DS2 papers | Newest fiscal year |
|---|---|---|---|
| P01CA065493 | Off-the-Shelf Immune Effector Cells for Hematological Malignancies | 24 | 2025 |
| P01CA111412 | NK cells, their receptors and cancer therapy | 21 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 13 | 2025 |
| U01AI069197 | Hematopoietic Stem Cell And Cord Blood Transplantation | 12 | 2025 |
| U01AI090905 | Insights Into Immune-Related Diseases Born from Population Genomics | 11 | 2025 |
| R01AI128775 | Integrated Exchange and Storage of Current- and Future-Generation Immunogenomic Data | 10 | 2025 |
| P30CA077598 | Cancer Center Support Grant | 9 | 2025 |
| U24CA076518 | A Data Resource for Blood and Marrow Transplants and Adoptive Cellular Therapy Research | 8 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 7 | 2025 |
| P30CA051008 | Georgetown University Lombardi Comprehensive Cancer Center Support Grant | 7 | 2025 |
1 to 10 of 667Source NIH's project files
See all 667 nih grantsPapers1,311
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
Beta-Glucan Supplementation Improves Clinical Outcomes and Preserves Immune Homeostasis in Patients with Advanced Solid Tumors Receiving Chemotherapy: A Prospective Phase II Randomized Three-Arm Clinical Trial. | Int J Mol Sci | 2026 | 42653193 | PubTator, text mining | PubMed |
| Cytotoxic CD4+ T cells: origin, biological functions, diseases and therapeutic targets. | Signal Transduct Target Ther | 2026 | 41803090 | PubTator, text mining | PubMed |
| Integrative Roles of NK Receptors and γδ TCRs in γδ T Cell-Mediated Cancer Immunity. | Immune Netw | 2026 | 41800030 | PubTator, text mining | PubMed |
| Mechanisms of tumor cell evasion from NK cell-mediated killing and advances in NK cell-based cancer immunotherapy. | Pharm Sci Adv | 2026 | 41799416 | PubTator, text mining | PubMed |
| Development and evaluation of an inhalable nanoemulsion system for enhancing NK cell function against osteosarcoma pulmonary metastases. | Front Immunol | 2026 | 41766883 | PubTator, text mining | PubMed |
| MicroRNA-mediated regulation of natural killer cells development, effector functions, and antitumor responses. | Cancer Cell Int | 2025 | 41331607 | PubTator, text mining | PubMed |
| IL-21-reprogrammed Vδ1 T cells exert killing against solid tumors which is enhanced by CAR arming for off-the-shelf immunotherapy. | Oncoimmunology | 2025 | 40996786 | PubTator, text mining | PubMed |
| Allele Level Sequencing of Killer Cell Immunoglobulin-Like Receptor Genes Using Oxford Nanopore Long Read Sequencing. | HLA | 2025 | 40985045 | PubTator, text mining | PubMed |
| Profiling associations of interactive ligand-receptors (HLA class I and KIR gene products) with the progression to type 1 diabetes among seroconverted participants. | Diabetologia | 2025 | 40835749 | PubTator, text mining | PubMed |
| Genomic and immunogenomic profiling of extramedullary acute myeloid leukemia reveals actionable clonal branching and frequent immune editing. | Blood Cancer J | 2025 | 40804254 | PubTator, text mining | PubMed |
1 to 10 of 1,311
See all 1,311 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/100132285
GET https://conductscience.org/api/genes/v1/100132285/patents?page=2