Gene · 10014
HDAC5: histone deacetylase 5
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. HDAC5: histone deacetylase 5. Genes, record 10014. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10014
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9UQL6 | Histone deacetylase 5 | 1,122 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents8
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 49225 | Q9UQL6 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 22012 | Q9UQL6 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 22012 | Q9UQL6 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 38606 | Q9UQL6 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 141577 | Q9UQL6 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 229660 | Q9UQL6 | Espacenet |
| JP 2017121241 A | 2017-07-13 | 229660 | Q9UQL6 | Espacenet |
| JP 2015516143 A | 2015-06-08 | 229660 | Q9UQL6 | Espacenet |
Drugs12
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ABEXINOSTAT | CHEMBL2103863 | Histone deacetylase inhibitor | INHIBITOR | ChEMBL |
| BELINOSTAT | CHEMBL408513 | Histone deacetylase inhibitor | INHIBITOR | ChEMBL |
| CUDC-101 | CHEMBL598797 | Histone deacetylase inhibitor | INHIBITOR | ChEMBL |
| ENTINOSTAT | CHEMBL27759 | Histone deacetylase inhibitor | INHIBITOR | ChEMBL |
| FIMEPINOSTAT | CHEMBL3622533 | Histone deacetylase inhibitor | INHIBITOR | ChEMBL |
| GIVINOSTAT | CHEMBL1213492 | Histone deacetylase inhibitor | INHIBITOR | ChEMBL |
| GIVINOSTAT HYDROCHLORIDE | CHEMBL6068400 | Histone deacetylase inhibitor | INHIBITOR | ChEMBL |
| PANOBINOSTAT | CHEMBL483254 | Histone deacetylase inhibitor | INHIBITOR | ChEMBL |
| PANOBINOSTAT LACTATE | CHEMBL3545368 | Histone deacetylase inhibitor | INHIBITOR | ChEMBL |
| QUISINOSTAT | CHEMBL2105763 | Histone deacetylase inhibitor | INHIBITOR | ChEMBL |
1 to 10 of 12
See all 12 drugsTrials389
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07492394 | ENTINOSTAT | PHASE2 | ClinicalTrials.gov | |
| NCT07441486 | ENTINOSTAT | PHASE2 | ClinicalTrials.gov | |
| NCT07330544 | ENTINOSTAT | PHASE2 | ClinicalTrials.gov | |
| NCT07261592 | ENTINOSTAT | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT07235618 | ENTINOSTAT | PHASE2 | ClinicalTrials.gov | |
| NCT06824662 | QUISINOSTAT | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT06769633 | GIVINOSTAT HYDROCHLORIDE | PHASE2 | ClinicalTrials.gov | |
| NCT06561048 | BELINOSTAT | PHASE3 | ClinicalTrials.gov | |
| NCT06406465 | BELINOSTAT | PHASE2 | ClinicalTrials.gov | |
| NCT06240520 | PANOBINOSTAT | PHASE1/PHASE2 | ClinicalTrials.gov |
1 to 10 of 389
See all 389 trialsNIH grants1,955
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | HDAC5 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 13 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 9 | 2025 |
| R01GM049758 | Structure and Function of Metalloenzymes | 7 | 2025 |
| P30CA047904 | Cancer Center Support Grant | 5 | 2025 |
| P01CA120964 | Molecular Pathogenesis of the Hamartoma Syndromes | 4 | 2025 |
| P30ES005022 | Rutgers Center for Environmental Exposure and Disease (CEED) | 4 | 2025 |
| R01DK116716 | The role of salt inducible kinases in parathyroid hormone action in bone | 4 | 2025 |
| T32AR056950 | Musculoskeletal Research Training Program | 4 | 2025 |
| U54DK106846 | Hematopoietic stem and progenitor cell regulation for enhanced clinical efficacy | 4 | 2025 |
| P30CA014195 | Cancer Center Support Grant (CCSG) | 3 | 2025 |
1 to 10 of 1,955Source NIH's project files
See all 1,955 nih grantsPapers2,885
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Proteogenomic Analysis of HDAC4 and HDAC5 in Uveal Melanoma. | Mol Med | 2026 | 42773415 | PubTator, text mining | PubMed |
| Transcriptomic and network analyses identify epigenetic regulators of drug-tolerant persister (DTP) subsets in EGFR-mutant HCC827 non-small cell lung cancer. | Genes Genomics | 2026 | 42742903 | PubTator, text mining | PubMed |
| Epigenetic repression of RGS2 transcription by HDAC5 contributes to deep vein thrombosis. | Life Sci | 2026 | 42617796 | PubTator, text mining | PubMed |
| The KAT2/HDACⅡa-PGK-ALDO axis constitutes a dual degradation inhibition cascade links energy stress to glycolytic amplification. | Proc Natl Acad Sci U S A | 2026 | 42611992 | PubTator, text mining | PubMed |
| Gastrointestinal axis in post-traumatic sepsis: from molecular mechanisms to translational perspectives. | Front Immunol | 2026 | 42539437 | PubTator, text mining | PubMed |
| Activating RARβ to overcome immunomodulatory drug resistance in t(4;14) human myeloma. | Leukemia | 2026 | 42533031 | PubTator, text mining | PubMed |
| Taurine ameliorates damages induced by acute heat stress on porcine Sertoli cells. | Theriogenology | 2026 | 42497608 | PubTator, text mining | PubMed |
| HDAC5 depletion promotes hyper-acetylation of FOXA1 and potentiates HIF1α transcriptional activation in pancreatic cancer. | Mol Cell | 2026 | 42413489 | PubTator, text mining | PubMed |
| Histone Deacetylase 7 protects against pathologic cardiac hypertrophy. | J Mol Cell Cardiol | 2026 | 42250622 | PubTator, text mining | PubMed |
| Hypophosphatemia as a Potential Class Effect of Histone Deacetylase Inhibitors: Evidence from Disproportionality Analysis and Mendelian Randomization Analysis of Drug Targets. | Pharmaceuticals (Basel) | 2026 | 42198363 | PubTator, text mining | PubMed |
1 to 10 of 2,885
See all 2,885 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/10014
GET https://conductscience.org/api/genes/v1/10014/drugs