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Gene · 10014

HDAC5: histone deacetylase 5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HDAC5: histone deacetylase 5. Genes, record 10014. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10014

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Gene

Symbol
HDAC5
HGNC
Name
histone deacetylase 5
HGNC
NCBI Gene ID
10014
NCBI Gene
HGNC ID
HGNC:14068
HGNC
Ensembl
ENSG00000108840
NCBI Gene
Aliases
FLJ90614, HD5, KIAA0600, NY-CO-9
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UQL6Histone deacetylase 51,1222Ensembl, GeneID, HGNC

Source UniProt

Patents8

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1449225Q9UQL6Espacenet
EP 4641201 A22025-10-2922012Q9UQL6Espacenet
JP 2025517969 A2025-06-1222012Q9UQL6Espacenet
US 11446398 B22022-09-2038606Q9UQL6Espacenet
JP 2022524081 A2022-04-27141577Q9UQL6Espacenet
JP 2019054813 A2019-04-11229660Q9UQL6Espacenet
JP 2017121241 A2017-07-13229660Q9UQL6Espacenet
JP 2015516143 A2015-06-08229660Q9UQL6Espacenet

Drugs12

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABEXINOSTATCHEMBL2103863Histone deacetylase inhibitorINHIBITORChEMBL
BELINOSTATCHEMBL408513Histone deacetylase inhibitorINHIBITORChEMBL
CUDC-101CHEMBL598797Histone deacetylase inhibitorINHIBITORChEMBL
ENTINOSTATCHEMBL27759Histone deacetylase inhibitorINHIBITORChEMBL
FIMEPINOSTATCHEMBL3622533Histone deacetylase inhibitorINHIBITORChEMBL
GIVINOSTATCHEMBL1213492Histone deacetylase inhibitorINHIBITORChEMBL
GIVINOSTAT HYDROCHLORIDECHEMBL6068400Histone deacetylase inhibitorINHIBITORChEMBL
PANOBINOSTATCHEMBL483254Histone deacetylase inhibitorINHIBITORChEMBL
PANOBINOSTAT LACTATECHEMBL3545368Histone deacetylase inhibitorINHIBITORChEMBL
QUISINOSTATCHEMBL2105763Histone deacetylase inhibitorINHIBITORChEMBL

1 to 10 of 12

See all 12 drugs

Trials389

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07492394ENTINOSTATPHASE2ClinicalTrials.gov
NCT07441486ENTINOSTATPHASE2ClinicalTrials.gov
NCT07330544ENTINOSTATPHASE2ClinicalTrials.gov
NCT07261592ENTINOSTATPHASE1/PHASE2ClinicalTrials.gov
NCT07235618ENTINOSTATPHASE2ClinicalTrials.gov
NCT06824662QUISINOSTATEARLY_PHASE1ClinicalTrials.gov
NCT06769633GIVINOSTAT HYDROCHLORIDEPHASE2ClinicalTrials.gov
NCT06561048BELINOSTATPHASE3ClinicalTrials.gov
NCT06406465BELINOSTATPHASE2ClinicalTrials.gov
NCT06240520PANOBINOSTATPHASE1/PHASE2ClinicalTrials.gov

1 to 10 of 389

See all 389 trials

NIH grants1,955

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHDAC5 papersNewest fiscal year
P30CA016672Cancer Center Support Grant132025
P30CA008748Cancer Center Support Grant92025
R01GM049758Structure and Function of Metalloenzymes72025
P30CA047904Cancer Center Support Grant52025
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes42025
P30ES005022Rutgers Center for Environmental Exposure and Disease (CEED)42025
R01DK116716The role of salt inducible kinases in parathyroid hormone action in bone42025
T32AR056950Musculoskeletal Research Training Program42025
U54DK106846Hematopoietic stem and progenitor cell regulation for enhanced clinical efficacy42025
P30CA014195Cancer Center Support Grant (CCSG)32025

1 to 10 of 1,955Source NIH's project files

See all 1,955 nih grants

Papers2,885

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Proteogenomic Analysis of HDAC4 and HDAC5 in Uveal Melanoma.Mol Med202642773415PubTator, text miningPubMed
Transcriptomic and network analyses identify epigenetic regulators of drug-tolerant persister (DTP) subsets in EGFR-mutant HCC827 non-small cell lung cancer.Genes Genomics202642742903PubTator, text miningPubMed
Epigenetic repression of RGS2 transcription by HDAC5 contributes to deep vein thrombosis.Life Sci202642617796PubTator, text miningPubMed
The KAT2/HDACⅡa-PGK-ALDO axis constitutes a dual degradation inhibition cascade links energy stress to glycolytic amplification.Proc Natl Acad Sci U S A202642611992PubTator, text miningPubMed
Gastrointestinal axis in post-traumatic sepsis: from molecular mechanisms to translational perspectives.Front Immunol202642539437PubTator, text miningPubMed
Activating RARβ to overcome immunomodulatory drug resistance in t(4;14) human myeloma.Leukemia202642533031PubTator, text miningPubMed
Taurine ameliorates damages induced by acute heat stress on porcine Sertoli cells.Theriogenology202642497608PubTator, text miningPubMed
HDAC5 depletion promotes hyper-acetylation of FOXA1 and potentiates HIF1α transcriptional activation in pancreatic cancer.Mol Cell202642413489PubTator, text miningPubMed
Histone Deacetylase 7 protects against pathologic cardiac hypertrophy.J Mol Cell Cardiol202642250622PubTator, text miningPubMed
Hypophosphatemia as a Potential Class Effect of Histone Deacetylase Inhibitors: Evidence from Disproportionality Analysis and Mendelian Randomization Analysis of Drug Targets.Pharmaceuticals (Basel)202642198363PubTator, text miningPubMed

1 to 10 of 2,885

See all 2,885 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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