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Gene · 100288687

DUX4: double homeobox 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DUX4: double homeobox 4. Genes, record 100288687. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/100288687

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Gene

Symbol
DUX4
HGNC
Name
double homeobox 4
HGNC
NCBI Gene ID
100288687
NCBI Gene
HGNC ID
HGNC:50800
HGNC
Ensembl
ENSG00000260596
NCBI Gene
Aliases
DUX4L
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UBX2Double homeobox protein 442411Ensembl, GeneID, HGNC

Source UniProt

Patents38

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4698657 A22026-02-25374Q9UBX2Espacenet
JP 2025186232 A2025-12-233Q9UBX2Espacenet
WO 2025212838 A12025-10-092Q9UBX2Espacenet
JP 2025147176 A2025-10-0614901Q9UBX2Espacenet
JP 2025032342 A2025-03-112Q9UBX2Espacenet
JP 2025028160 A2025-02-2814901Q9UBX2Espacenet
KR 1020250010750 A2025-01-2114901Q9UBX2Espacenet
JP 2024109657 A2024-08-1414740Q9UBX2Espacenet
JP 2024524265 A2024-07-052Q9UBX2Espacenet
JP 2024505575 A2024-02-06152Q9UBX2Espacenet

1 to 10 of 38

See all 38 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants730

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDUX4 papersNewest fiscal year
P30CA008748Cancer Center Support Grant352025
R01AR045203D4Z4 Coding Transcripts and FSHD352025
P30CA021765Cancer Center Support Grant (CCSG)302025
R01AR055685Probing the activity of DUX4 in FSHD252025
R35CA197695Translating genomic discoveries to improved outcomes for high risk acute leukemia152025
U10CA180886COG NCTN Network Group Operations Center - Year 11 STAR Act MCI and PEC Supplement102025
U10CA180899Children's Oncology Group Statistics and Data Center92025
P30CA015704Cancer Center Support Grant82025
P50CA217694SPORE in Soft Tissue Sarcoma82025
T32HG000035Interdisciplinary Training in Genome Sciences82025

1 to 10 of 730Source NIH's project files

See all 730 nih grants

Papers1,532

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Nanopore Ultra-Long Sequencing for FSHD: From Molecular Diagnosis to Preimplantation Genetic Testing.Genes (Basel)202642792998PubTator, text miningPubMed
Undifferentiated round cell sarcoma with CIC::NUTM1 fusion: expanding the clinicopathologic spectrum of a rare molecular variant of CIC-rearranged sarcoma.Virchows Arch202642693277PubTator, text miningPubMed
EARLY RESPONSE AND GENETICS DEFINE RELAPSE RISK AFTER FRONTLINE BLINATUMOMAB IN CHILDHOOD B-ALL: A COHORT STUDY.Blood Adv202642679210PubTator, text miningPubMed
Biomarkers in facioscapulohumeral muscular dystrophy.Curr Opin Neurol202642630082PubTator, text miningPubMed
Cup-Like Nuclei Is a Hallmark of DUX4/ERG Acute Lymphoblastic Leukemia and Reveals Cytoplasmic Mitochondria Accumulation.Pediatr Blood Cancer202642520297PubTator, text miningPubMed
Personalized reference genome-based pipeline reveals comprehensive haplotype-resolved views of cancer genomes.bioRxiv202642465473PubTator, text miningPubMed
MYH2 as a Potential Modifier of Clinical Severity in Facioscapulohumeral Muscular Dystrophy.J Mol Neurosci202642390820PubTator, text miningPubMed
Cytological Features of CIC-Rearranged Sarcoma: A Report of 5 New Cases and Review of the Literature.Acta Cytol202642378138PubTator, text miningPubMed
Identification of compounds that repress DUX4 expression in facioscapulohumeral muscular dystrophy.Sci Rep202642304059PubTator, text miningPubMed
Targeting CIC::DUX4 sarcoma with Minnelide in a dual recombinase-initiated genetically engineered mouse model.J Clin Invest202642302177PubTator, text miningPubMed

1 to 10 of 1,532

See all 1,532 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/100288687

GET https://conductscience.org/api/genes/v1/100288687/patents?page=2