Gene · 100289462
DEFB4B: defensin beta 4B
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. DEFB4B: defensin beta 4B. Genes, record 100289462. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/100289462
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O15263 | Defensin beta 4A | 64 | 6 | Ensembl, GeneID, HGNC |
Source UniProt
Patents122
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 14808 | O15263 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 4221 | O15263 | Espacenet |
| JP 2025169942 A | 2025-11-14 | 944 | O15263 | Espacenet |
| JP 2025169942 A | 2025-11-14 | 945 | O15263 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 4167 | O15263 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 4168 | O15263 | Espacenet |
| US 12409247 B2 | 2025-09-09 | 85 | O15263 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6168 | O15263 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6169 | O15263 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 6168 | O15263 | Espacenet |
1 to 10 of 122
See all 122 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants805
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | DEFB4B papers | Newest fiscal year |
|---|---|---|---|
| R01AR040312 | CD1-restricted T-cell Responses in Skin | 7 | 2025 |
| R01AI022553 | Molecular Analysis of Host Immune Response in Leprosy | 5 | 2025 |
| UL1TR001866 | Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success | 4 | 2025 |
| P30AI042853 | Providence/Boston Center for AIDS Research (CFAR) | 3 | 2025 |
| P30AR069625 | Human Skin Disease Resource-based Center | 3 | 2025 |
| P30CA046592 | University of Michigan Rogel Cancer Center Support Grant 2023-2028 | 3 | 2025 |
| P30DK056338 | Texas Medical Center Digestive Diseases Center | 3 | 2025 |
| P30DK097948 | The Cleveland Digestive Diseases Research Core Center (DDRCC) | 3 | 2025 |
| K08AR078251 | Mechanisms of sex discrepancy in autoimmune disease: Regulation of the female-biased VGLL3 immune pathway | 2 | 2025 |
| P30AI027767 | UAB Center for AIDS Research (CFAR) | 2 | 2025 |
1 to 10 of 805Source NIH's project files
See all 805 nih grantsPapers1,477
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Comparative Effects of Pairwise Combinations of Carboplatin, Everolimus, and Astaxanthin on Cell Viability, Migration, and Inflammatory Biomarkers in SKOV3 Ovarian Cancer Cells. | Int J Mol Sci | 2026 | 42794426 | PubTator, text mining | PubMed |
| Efficacy of biotene and xerostom on salivary function, biomarkers, and caries risk in radiation-induced xerostomia: A randomized controlled trial. | J Conserv Dent Endod | 2026 | 42781252 | PubTator, text mining | PubMed |
| Development of a potential vaccine against dengue and chikungunya virus co-infection using immunoinformatics and structural evaluation. | J Genet Eng Biotechnol | 2026 | 42749444 | PubTator, text mining | PubMed |
| The analysis of cervicovaginal microbiota and immune mediators in patients with adenomyosis. | Wiad Lek | 2026 | 42748297 | PubTator, text mining | PubMed |
| Efficacy of Bifidobacterium lactis BLa80 in preventing early childhood eczema and respiratory infections via gut microbiome and immune modulation. | Front Nutr | 2026 | 42293186 | PubTator, text mining | PubMed |
| Serum Defensins in Differentiating Idiopathic Granulomatous Mastitis from Breast Cancer-Defensins in Idiopathic Granulomatous Mastitis and Breast Cancer. | J Clin Med | 2026 | 42194622 | PubTator, text mining | PubMed |
| Integrated Inflammatory Biomarker Profiling Differentiates Degrees of Body Mass Index Beyond Intestinal Barrier-Related Markers. | Cells | 2026 | 42121864 | PubTator, text mining | PubMed |
| Mind-Body Movement-Based Interventions and Periodontal Health: A Scoping Review. | Dent J (Basel) | 2026 | 41892751 | PubTator, text mining | PubMed |
| Upregulated beta-defensin-1 in murine and human biliary atresia associates with human native liver survival. | Sci Rep | 2026 | 41888359 | PubTator, text mining | PubMed |
| Novel Food Supplement Containing a Combination of Postbiotics and Plant-Derived Compounds Regulates Epithelial Barrier Integrity and Immune Response in Human Enterocytes. | Foods | 2026 | 41829192 | PubTator, text mining | PubMed |
1 to 10 of 1,477
See all 1,477 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/100289462
GET https://conductscience.org/api/genes/v1/100289462/patents?page=2