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Gene · 100289462

DEFB4B: defensin beta 4B

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DEFB4B: defensin beta 4B. Genes, record 100289462. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/100289462

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Gene

Symbol
DEFB4B
HGNC
Name
defensin beta 4B
HGNC
NCBI Gene ID
100289462
NCBI Gene
HGNC ID
HGNC:30193
HGNC
Ensembl
ENSG00000177257
NCBI Gene
Aliases
DEFB4P
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O15263Defensin beta 4A646Ensembl, GeneID, HGNC

Source UniProt

Patents122

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1914808O15263Espacenet
EP 4650780 A22025-11-194221O15263Espacenet
JP 2025169942 A2025-11-14944O15263Espacenet
JP 2025169942 A2025-11-14945O15263Espacenet
JP 2025147176 A2025-10-064167O15263Espacenet
JP 2025147176 A2025-10-064168O15263Espacenet
US 12409247 B22025-09-0985O15263Espacenet
JP 2025529142 A2025-09-046168O15263Espacenet
JP 2025529142 A2025-09-046169O15263Espacenet
US 12371689 B22025-07-296168O15263Espacenet

1 to 10 of 122

See all 122 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants805

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDEFB4B papersNewest fiscal year
R01AR040312CD1-restricted T-cell Responses in Skin72025
R01AI022553Molecular Analysis of Host Immune Response in Leprosy52025
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success42025
P30AI042853Providence/Boston Center for AIDS Research (CFAR)32025
P30AR069625Human Skin Disease Resource-based Center32025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202832025
P30DK056338Texas Medical Center Digestive Diseases Center32025
P30DK097948The Cleveland Digestive Diseases Research Core Center (DDRCC)32025
K08AR078251Mechanisms of sex discrepancy in autoimmune disease: Regulation of the female-biased VGLL3 immune pathway22025
P30AI027767UAB Center for AIDS Research (CFAR)22025

1 to 10 of 805Source NIH's project files

See all 805 nih grants

Papers1,477

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Comparative Effects of Pairwise Combinations of Carboplatin, Everolimus, and Astaxanthin on Cell Viability, Migration, and Inflammatory Biomarkers in SKOV3 Ovarian Cancer Cells.Int J Mol Sci202642794426PubTator, text miningPubMed
Efficacy of biotene and xerostom on salivary function, biomarkers, and caries risk in radiation-induced xerostomia: A randomized controlled trial.J Conserv Dent Endod202642781252PubTator, text miningPubMed
Development of a potential vaccine against dengue and chikungunya virus co-infection using immunoinformatics and structural evaluation.J Genet Eng Biotechnol202642749444PubTator, text miningPubMed
The analysis of cervicovaginal microbiota and immune mediators in patients with adenomyosis.Wiad Lek202642748297PubTator, text miningPubMed
Efficacy of Bifidobacterium lactis BLa80 in preventing early childhood eczema and respiratory infections via gut microbiome and immune modulation.Front Nutr202642293186PubTator, text miningPubMed
Serum Defensins in Differentiating Idiopathic Granulomatous Mastitis from Breast Cancer-Defensins in Idiopathic Granulomatous Mastitis and Breast Cancer.J Clin Med202642194622PubTator, text miningPubMed
Integrated Inflammatory Biomarker Profiling Differentiates Degrees of Body Mass Index Beyond Intestinal Barrier-Related Markers.Cells202642121864PubTator, text miningPubMed
Mind-Body Movement-Based Interventions and Periodontal Health: A Scoping Review.Dent J (Basel)202641892751PubTator, text miningPubMed
Upregulated beta-defensin-1 in murine and human biliary atresia associates with human native liver survival.Sci Rep202641888359PubTator, text miningPubMed
Novel Food Supplement Containing a Combination of Postbiotics and Plant-Derived Compounds Regulates Epithelial Barrier Integrity and Immune Response in Human Enterocytes.Foods202641829192PubTator, text miningPubMed

1 to 10 of 1,477

See all 1,477 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/100289462

GET https://conductscience.org/api/genes/v1/100289462/patents?page=2