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Gene · 10036

CHAF1A: chromatin assembly factor 1 subunit A

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CHAF1A: chromatin assembly factor 1 subunit A. Genes, record 10036. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10036

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Gene

Symbol
CHAF1A
HGNC
Name
chromatin assembly factor 1 subunit A
HGNC
NCBI Gene ID
10036
NCBI Gene
HGNC ID
HGNC:1910
HGNC
Ensembl
ENSG00000167670
NCBI Gene
Aliases
CAF-1, CAF1, CAF1B, CAF1P150, MGC71229, P150
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13111Chromatin assembly factor 1 subunit A95611Ensembl, GeneID, HGNC

Source UniProt

Patents6

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-293628Q13111Espacenet
JP 2025517969 A2025-06-123628Q13111Espacenet
US 11446398 B22022-09-2015190Q13111Espacenet
JP 2022524081 A2022-04-27118161Q13111Espacenet
US 11078247 B22021-08-032101Q13111Espacenet
EP 1806413 A12007-07-11288Q13111Espacenet

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,854

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCHAF1A papersNewest fiscal year
P01CA013106Targeting Transcription and Splicing in Cancer142025
P30CA008748Cancer Center Support Grant82025
P30CA010815Consolidated Basic Cancer Research Program72025
R35GM128661Investigating the roles of the H3.1-TSK/TONSL pathway during chromatin replication72025
P30CA006927Comprehensive Cancer Center Program at Fox Chase62025
R01DK057819Intestinal Mucosal Growth in Health and Surgical Diseases62025
P01CA092584Structural Cell Biology of DNA Repair Machines52025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center52025
P30CA013696Cancer Center Support Grant42025
P30CA016087Cancer Center Support Grant42025

1 to 10 of 1,854Source NIH's project files

See all 1,854 nih grants

Papers2,603

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
CAF-1 in Replication and Repair: A Critical Genetic Mediator of Synthesis-Coupled Nucleosome Assembly.Biomolecules202642793109PubTator, text miningPubMed
FACT-(H3-H4) complex stimulates Pol α activity to coordinate DNA synthesis with nucleosome assembly.Sci Adv202642789711PubTator, text miningPubMed
Integrative proteomics reveals MSH6 to modulate PARP inhibitor sensitivity in BRCA1/2-proficient ovarian cancer.PLoS One202642685115PubTator, text miningPubMed
Receptor specificity and translational considerations for laminin-mimetic Caf1 scaffolds: reply from authors.Br J Dermatol202642574656PubTator, text miningPubMed
CHAF1A promotes RAD51 loading and homologous recombination to drive tumor radioresistance.Oncogene202642552448PubTator, text miningPubMed
CHAF1A identified as a candidate biomarker and potential therapeutic target in Burkitt lymphoma through integrated bioinformatics and histopathological analysis.Hematology202642535765PubTator, text miningPubMed
Chaf1a is required for cardiomyocyte karyokinesis and cardiac endowment.Protein Cell202642500988PubTator, text miningPubMed
The role of electrostatic interactions in the phase separation of HP1α and its protein binding partners.bioRxiv202642465301PubTator, text miningPubMed
Elevated CHAF1A Suppresses Type I Interferon Production and Causes Immunotherapy Resistance in Esophageal Squamous Cell Carcinoma.Cancer Immunol Res202642462139PubTator, text miningPubMed
Targeting ADAR1 p150 triggers tumor inhibition and antitumor immunity to overcome immunotherapy resistance.iScience202642221825PubTator, text miningPubMed

1 to 10 of 2,603

See all 2,603 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10036

GET https://conductscience.org/api/genes/v1/10036/grants?page=2