Gene · 10036
CHAF1A: chromatin assembly factor 1 subunit A
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CHAF1A: chromatin assembly factor 1 subunit A. Genes, record 10036. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10036
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q13111 | Chromatin assembly factor 1 subunit A | 956 | 11 | Ensembl, GeneID, HGNC |
Source UniProt
Patents6
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4641201 A2 | 2025-10-29 | 3628 | Q13111 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 3628 | Q13111 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 15190 | Q13111 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 118161 | Q13111 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 2101 | Q13111 | Espacenet |
| EP 1806413 A1 | 2007-07-11 | 288 | Q13111 | Espacenet |
Drugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,854
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CHAF1A papers | Newest fiscal year |
|---|---|---|---|
| P01CA013106 | Targeting Transcription and Splicing in Cancer | 14 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 8 | 2025 |
| P30CA010815 | Consolidated Basic Cancer Research Program | 7 | 2025 |
| R35GM128661 | Investigating the roles of the H3.1-TSK/TONSL pathway during chromatin replication | 7 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 6 | 2025 |
| R01DK057819 | Intestinal Mucosal Growth in Health and Surgical Diseases | 6 | 2025 |
| P01CA092584 | Structural Cell Biology of DNA Repair Machines | 5 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 5 | 2025 |
| P30CA013696 | Cancer Center Support Grant | 4 | 2025 |
| P30CA016087 | Cancer Center Support Grant | 4 | 2025 |
1 to 10 of 1,854Source NIH's project files
See all 1,854 nih grantsPapers2,603
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| CAF-1 in Replication and Repair: A Critical Genetic Mediator of Synthesis-Coupled Nucleosome Assembly. | Biomolecules | 2026 | 42793109 | PubTator, text mining | PubMed |
| FACT-(H3-H4) complex stimulates Pol α activity to coordinate DNA synthesis with nucleosome assembly. | Sci Adv | 2026 | 42789711 | PubTator, text mining | PubMed |
| Integrative proteomics reveals MSH6 to modulate PARP inhibitor sensitivity in BRCA1/2-proficient ovarian cancer. | PLoS One | 2026 | 42685115 | PubTator, text mining | PubMed |
| Receptor specificity and translational considerations for laminin-mimetic Caf1 scaffolds: reply from authors. | Br J Dermatol | 2026 | 42574656 | PubTator, text mining | PubMed |
| CHAF1A promotes RAD51 loading and homologous recombination to drive tumor radioresistance. | Oncogene | 2026 | 42552448 | PubTator, text mining | PubMed |
| CHAF1A identified as a candidate biomarker and potential therapeutic target in Burkitt lymphoma through integrated bioinformatics and histopathological analysis. | Hematology | 2026 | 42535765 | PubTator, text mining | PubMed |
| Chaf1a is required for cardiomyocyte karyokinesis and cardiac endowment. | Protein Cell | 2026 | 42500988 | PubTator, text mining | PubMed |
| The role of electrostatic interactions in the phase separation of HP1α and its protein binding partners. | bioRxiv | 2026 | 42465301 | PubTator, text mining | PubMed |
| Elevated CHAF1A Suppresses Type I Interferon Production and Causes Immunotherapy Resistance in Esophageal Squamous Cell Carcinoma. | Cancer Immunol Res | 2026 | 42462139 | PubTator, text mining | PubMed |
| Targeting ADAR1 p150 triggers tumor inhibition and antitumor immunity to overcome immunotherapy resistance. | iScience | 2026 | 42221825 | PubTator, text mining | PubMed |
1 to 10 of 2,603
See all 2,603 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/10036
GET https://conductscience.org/api/genes/v1/10036/grants?page=2