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PARP2: poly(ADP-ribose) polymerase 2
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Gene · 10038

Papers2,674

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

1 to 20 of 2,674

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TitleJournalYearPMIDFound bySource
Screening of Programmed Cell Death-Related Biomarkers and Exploration of Mechanisms in Zhenwu Decoction for Treating Chronic Kidney Disease.Comb Chem High Throughput Screen202642817110PubTator, text miningPubMed
ZIPPing the gaps: A new class of zinc finger proteins orchestrates the DNA damage response.DNA Repair (Amst)202642762747PubTator, text miningPubMed
Optimization of a Second-Generation, Highly Selective Polθ/PARP1 Dual Inhibitor with Improved Pharmacokinetics and Potent Activity against HR-Deficient Tumors.J Med Chem202642720455PubTator, text miningPubMed
Integrative proteomics reveals MSH6 to modulate PARP inhibitor sensitivity in BRCA1/2-proficient ovarian cancer.PLoS One202642685115PubTator, text miningPubMed
Heterocyclic Scaffolds in PARP-1 Inhibition: An Emerging Strategy for Targeted Anticancer Therapy.Mini Rev Med Chem202642634307PubTator, text miningPubMed
From dual inhibition to precision selectivity: the molecular rationale and clinical evolution of next-generation PARP1-selective inhibitors in solid tumors.Front Oncol202642568603PubTator, text miningPubMed
Discovery of DA1 as PARP inhibitor for the treatment of BRCA-proficient triple negative breast cancer by suppressing the PI3K/AKT/mTOR signaling pathway.Bioorg Med Chem202642531674PubTator, text miningPubMed
ROS-Induced DNA Damage Enhances Sensitivity to PARP Inhibition in HSC3 and SCC25 Head and Neck Squamous Cell Carcinoma Cell Lines.Curr Issues Mol Biol202642510932PubTator, text miningPubMed
Allosteric activation of PARP2 self-PARylation by SUMO constrains DNA-break-dependent catalytic functions.FEBS J202642479900PubTator, text miningPubMed
Integrating single-cell sQTL mapping with deep-learning splicing prediction identifies causal variants under influenza infection.Genome Biol202642471654PubTator, text miningPubMed
Development of Selective PARP1 Inhibitors for the Treatment of Cancer.ACS Med Chem Lett202642445017PubTator, text miningPubMed
[How to prevent and manage PARP inhibitor-related hematological toxicities in prostate cancer?]Bull Cancer202642425824PubTator, text miningPubMed
Potent and isoform-selective PARP1 degraders for the treatment of BRCA-deficient cancers.Bioorg Chem202642419053PubTator, text miningPubMed
G-quadruplex homeostasis is a determinant of PARP inhibitor toxicity in BRCA2-deficient cells.Nat Commun202642399234PubTator, text miningPubMed
A Novel, Robust, and Isocratic HPLC-UV Method for the Comprehensive Determination of Enantiomeric Impurity (R-Isomer) in Niraparib Drug Substance.Chirality202642304726PubTator, text miningPubMed
HM568 Enhances NAD+ Biosynthesis to Ameliorate Mitochondrial Dysfunction and Neurotoxicity in Parkinson's Disease Models: A Putative Link to PARP1 Modulation.Mol Neurobiol202642247013PubTator, text miningPubMed
Loss of CHTF18-RFC2/5 leads to replicative gaps and sensitivity to PARP inhibitors.NAR Cancer202642244520PubTator, text miningPubMed
Structural Determinants of PARP1 Selectivity from Molecular Dynamics Analysis of PARP1 and PARP2 Complexes.Molecules202642197145PubTator, text miningPubMed
Cooperative molecular interaction networks govern PARP1 inhibitor selectivity and binding affinity.PLoS Comput Biol202642189893PubTator, text miningPubMed
PARP1-specific inhibitor displays PARP1-detrapping activity.Cell Rep202642090288PubTator, text miningPubMed

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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