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Gene · 10038

PARP2: poly(ADP-ribose) polymerase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PARP2: poly(ADP-ribose) polymerase 2. Genes, record 10038. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10038

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Gene

Symbol
PARP2
HGNC
Name
poly(ADP-ribose) polymerase 2
HGNC
NCBI Gene ID
10038
NCBI Gene
HGNC ID
HGNC:272
HGNC
Ensembl
ENSG00000129484
NCBI Gene
Aliases
ADPRT2, ADPRTL2, ADPRTL3, ARTD2, PARP-2, pADPRT-2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UGN5Poly [ADP-ribose] polymerase 258330Ensembl, GeneID, HGNC

Source UniProt

Patents30

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4464338 A22024-11-20149Q9UGN5Espacenet
JP 2024123008 A2024-09-107751Q9UGN5Espacenet
US 11976334 B22024-05-07176Q9UGN5Espacenet
US 11680268 B22023-06-20149Q9UGN5Espacenet
US 11446398 B22022-09-2064495Q9UGN5Espacenet
JP 2022524081 A2022-04-27167466Q9UGN5Espacenet
US 11293927 B22022-04-0514Q9UGN5Espacenet
US 10695341 B22020-06-30227Q9UGN5Espacenet
WO 2020058277 A12020-03-266Q9UGN5Espacenet
JP 2020508335 A2020-03-19176Q9UGN5Espacenet

1 to 10 of 30

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Drugs12

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
2X-121CHEMBL3644587Poly [ADP-ribose] polymerase 2 inhibitorINHIBITORChEMBL
E-7016CHEMBL3527000PARP 1, 2 and 3 inhibitorINHIBITORChEMBL
NIRAPARIBCHEMBL1094636Poly [ADP-ribose] polymerase 2 inhibitorINHIBITORChEMBL
NIRAPARIB TOSYLATE MONOHYDRATECHEMBL3989922Poly [ADP-ribose] polymerase 2 inhibitorINHIBITORChEMBL
OLAPARIBCHEMBL521686PARP 1, 2 and 3 inhibitorINHIBITORChEMBL
PAMIPARIBCHEMBL4112930Poly [ADP-ribose] polymerase 2 inhibitorINHIBITORChEMBL
RUCAPARIBCHEMBL1173055PARP 1, 2 and 3 inhibitorINHIBITORChEMBL
RUCAPARIB CAMSYLATECHEMBL3833368PARP 1, 2 and 3 inhibitorINHIBITORChEMBL
SENAPARIBCHEMBL4802152Poly [ADP-ribose] polymerase 2 inhibitorINHIBITORChEMBL
TALAZOPARIBCHEMBL3137320Poly [ADP-ribose] polymerase 2 inhibitorINHIBITORChEMBL

1 to 10 of 12

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Trials819

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants1,388

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePARP2 papersNewest fiscal year
P30CA016672Cancer Center Support Grant272025
P01CA092584Structural Cell Biology of DNA Repair Machines192025
P30CA008748Cancer Center Support Grant182025
P30CA047904Cancer Center Support Grant182025
R01DK069710The Role of Nuclear PARPs in Signal-Regulated Transcription152025
P50CA136393Use of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancer112025
ZIABC006150DNA Repair, Cell Cycle Checkpoints and Apoptosis as Targets for Anticancer Drugs112025
ZIABC011078Phase 0-1 Clinical Trials112025
R01CA218255Structure and Mechanism of Chromatin-Bound PARP192025
P30CA006973Regional Oncology Research Center82025

1 to 10 of 1,388Source NIH's project files

See all 1,388 nih grants

Papers2,674

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Screening of Programmed Cell Death-Related Biomarkers and Exploration of Mechanisms in Zhenwu Decoction for Treating Chronic Kidney Disease.Comb Chem High Throughput Screen202642817110PubTator, text miningPubMed
ZIPPing the gaps: A new class of zinc finger proteins orchestrates the DNA damage response.DNA Repair (Amst)202642762747PubTator, text miningPubMed
Optimization of a Second-Generation, Highly Selective Polθ/PARP1 Dual Inhibitor with Improved Pharmacokinetics and Potent Activity against HR-Deficient Tumors.J Med Chem202642720455PubTator, text miningPubMed
Integrative proteomics reveals MSH6 to modulate PARP inhibitor sensitivity in BRCA1/2-proficient ovarian cancer.PLoS One202642685115PubTator, text miningPubMed
Heterocyclic Scaffolds in PARP-1 Inhibition: An Emerging Strategy for Targeted Anticancer Therapy.Mini Rev Med Chem202642634307PubTator, text miningPubMed
From dual inhibition to precision selectivity: the molecular rationale and clinical evolution of next-generation PARP1-selective inhibitors in solid tumors.Front Oncol202642568603PubTator, text miningPubMed
Discovery of DA1 as PARP inhibitor for the treatment of BRCA-proficient triple negative breast cancer by suppressing the PI3K/AKT/mTOR signaling pathway.Bioorg Med Chem202642531674PubTator, text miningPubMed
ROS-Induced DNA Damage Enhances Sensitivity to PARP Inhibition in HSC3 and SCC25 Head and Neck Squamous Cell Carcinoma Cell Lines.Curr Issues Mol Biol202642510932PubTator, text miningPubMed
Allosteric activation of PARP2 self-PARylation by SUMO constrains DNA-break-dependent catalytic functions.FEBS J202642479900PubTator, text miningPubMed
Integrating single-cell sQTL mapping with deep-learning splicing prediction identifies causal variants under influenza infection.Genome Biol202642471654PubTator, text miningPubMed

1 to 10 of 2,674

See all 2,674 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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