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Gene · 10049

DNAJB6: DnaJ heat shock protein family (Hsp40) member B6

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DNAJB6: DnaJ heat shock protein family (Hsp40) member B6. Genes, record 10049. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10049

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Gene

Symbol
DNAJB6
HGNC
Name
DnaJ heat shock protein family (Hsp40) member B6
HGNC
NCBI Gene ID
10049
NCBI Gene
HGNC ID
HGNC:14888
HGNC
Ensembl
ENSG00000105993
NCBI Gene
Aliases
DJ4, DnaJ, HHDJ1, HSJ-2, HSJ2, LGMD1D, LGMD1E, LGMDD1, MRJ, MSJ-1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O75190DnaJ homolog subfamily B member 63264Ensembl, GeneID, HGNC

Source UniProt

Patents30

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1444107O75190Espacenet
EP 4650780 A22025-11-192026O75190Espacenet
EP 4641201 A22025-10-291590O75190Espacenet
JP 2025517969 A2025-06-121590O75190Espacenet
JP 2025517970 A2025-06-122026O75190Espacenet
JP 2025032204 A2025-03-1127387O75190Espacenet
EP 4484957 A12025-01-01128O75190Espacenet
EP 4461818 A22024-11-1327387O75190Espacenet
WO 2023162878 A2023-08-31128O75190Espacenet
JP 2023058610 A2023-04-2527387O75190Espacenet

1 to 10 of 30

See all 30 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,554

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDNAJB6 papersNewest fiscal year
R01NS059690Molecular Chaperones and Small Molecules152025
P30CA008748Cancer Center Support Grant122025
R01AR068797Chaperone Dysfunction in Myopathy: Connecting Yeast Genetics with Mouse Models112025
R01HL107304Epicardial remodeling in cardiomyopathy and cardiac aging82025
K24AR073317Clinical and Translational studies in muscle disease72025
R01HL081753Genetic Studies of Sarcomere-based Cardiac Diseases72025
R01NS073899The hsp90 Cochaperone FKBP51 Regulates tau Structure and Function72025
R01AG031867Protein aggregation in inclusion body and myofibrillar myopathies62025
P30CA016672Cancer Center Support Grant52025
P30CA021765Cancer Center Support Grant (CCSG)52025

1 to 10 of 1,554Source NIH's project files

See all 1,554 nih grants

Papers2,435

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
PTBP1-Mediated Alternative Splicing of DNAJB6 Promotes Everolimus Resistance in Clear Cell Renal Cell Carcinoma via EIF4B/PKIB/AKT/mTOR Positive Feedback Loop.Adv Sci (Weinh)202642801686PubTator, text miningPubMed
A Novel Plate Reader-Based Protocol for Measurement of DNAJB6 Dimerization Activity.Bio Protoc202642577708PubTator, text miningPubMed
Accurate interdomain contacts in a mixed folded protein from NMR-guided coarse-grained simulations.Phys Chem Chem Phys202642370432PubTator, text miningPubMed
Small bites for big problems: stepwise aggregate degradation by autophagy.Biochem Soc Trans202642325197PubTator, text miningPubMed
Interacting proteins of AMPK studied using TurboID proximity labeling technology.Exp Ther Med202642022757PubTator, text miningPubMed
Microplastic-induced transcriptional stress in the filter-feeding ciliate Stentor coeruleus: A novel avenue for understanding unicellular responses.Eur J Protistol202641996776PubTator, text miningPubMed
Transient Aggregation-Prone States in Disordered Proteins as Therapeutic Targets: The Amyloid-β Case.J Chem Inf Model202641981770PubTator, text miningPubMed
Hsp70 diversification and repurposing across the tree of life: Lessons from the evolutionary and mechanistic trajectory of the Hsp70-Hsp110 chaperone system.FEBS J202641981728PubTator, text miningPubMed
Misfolded Proteins and Cognitive Decline: Mechanistic Insights into Neurodegenerative Disorders.Neurol Int202641893050PubTator, text miningPubMed
Advances in the biological functions of miR‑205 in various diseases (Review).Mol Med Rep202641860043PubTator, text miningPubMed

1 to 10 of 2,435

See all 2,435 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10049

GET https://conductscience.org/api/genes/v1/10049/patents?page=2