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Gene · 100506742

CASP12: caspase 12 (gene/pseudogene)

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CASP12: caspase 12 (gene/pseudogene). Genes, record 100506742. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/100506742

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Gene

Symbol
CASP12
HGNC
Name
caspase 12 (gene/pseudogene)
HGNC
NCBI Gene ID
100506742
NCBI Gene
HGNC ID
HGNC:19004
HGNC
Ensembl
ENSG00000204403
NCBI Gene
Aliases
CASP-12, CASP12P1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q6UXS9Inactive caspase-123410Ensembl, GeneID, HGNC

Source UniProt

Patents4

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 2450456 A22012-05-09181Q6UXS9Espacenet
US 8026065 B22011-09-27181Q6UXS9Espacenet
JP 2010508815 A2010-03-25281Q6UXS9Espacenet
EP 2092074 A22009-08-26181Q6UXS9Espacenet

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
EMRICASANCHEMBL197672Caspase inhibitorINHIBITOR

Source ChEMBL

Trials11

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04803227EMRICASANPHASE1ClinicalTrials.gov
NCT03205345EMRICASANPHASE2ClinicalTrials.gov
NCT02686762EMRICASANPHASE2ClinicalTrials.gov
NCT02230683EMRICASANPHASE22016-12-21ClinicalTrials.gov
NCT02230670EMRICASANPHASE22017-07-05ClinicalTrials.gov
NCT02138253EMRICASANPHASE22019-12-11ClinicalTrials.gov
NCT02077374EMRICASANPHASE22016-07-21ClinicalTrials.gov
NCT01937130EMRICASANPHASE22016-04-11ClinicalTrials.gov
NCT01912404EMRICASANPHASE22016-11-04ClinicalTrials.gov
NCT01653899EMRICASANPHASE1/PHASE2ClinicalTrials.gov

1 to 10 of 11

See all 11 trials

NIH grants377

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCASP12 papersNewest fiscal year
R01GM100482Center for Critical Assessment of Structure Prediction (CASP)222025
P01AG005842Understanding and Improving Healthcare Decision-Making and Outcomes for People Living with Alzheimer's Disease and Related Dementias152025
R01AI134678Structure-based functional annotation of microbial genomes102025
U01AG009740Health and Retirement Study: Yrs 35-4092025
R35GM118078Analysis and Prediction of Molecular Interactions42025
R35GM126948Modeling and dynamics of biomolecules on cellular scales32025
P01CA092584Structural Cell Biology of DNA Repair Machines22025
P30ES005022Rutgers Center for Environmental Exposure and Disease (CEED)22025
P30ES017885Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)22025
P30GM124169ALS Efficiently Networking Advanced Beam Line Experiments (ALS-ENABLE)22025

1 to 10 of 377Source NIH's project files

See all 377 nih grants

Papers850

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Association between psychological wellbeing and the COVID-19-related outcomes in Europeans aged ≥ 50 years old: The SHARE study.Hum Vaccin Immunother202642610257PubTator, text miningPubMed
Prognostic Value of Endoplasmic Reticulum Stress-Related Gene Signature in Thyroid Cancer.Curr Med Sci202642406224PubTator, text miningPubMed
Associations between handgrip strength, motor tasks, and quality of life in older adults with osteoarthritis.Eur J Appl Physiol202641351757PubTator, text miningPubMed
Pathway-guided architectures for interpretable AI in biological research.Comput Struct Biotechnol J202541282420PubTator, text miningPubMed
Culturally appropriate physical activity promotion strategy package among older Chinese adults in the UK: a feasibility randomised control trial protocol.Pilot Feasibility Stud202541194268PubTator, text miningPubMed
Stable Marital Histories Predict Happiness and Health Across Educational Groups.Eur J Popul202540358790PubTator, text miningPubMed
The Historical Evolution and Significance of Multiple Sequence Alignment in Molecular Structure and Function Prediction.Biomolecules202439766238PubTator, text miningPubMed
Bilingual language model for protein sequence and structure.NAR Genom Bioinform202439633723PubTator, text miningPubMed
DCMA: faster protein backbone dihedral angle prediction using a dilated convolutional attention-based neural network.Front Bioinform202439493577PubTator, text miningPubMed
PatchProt: hydrophobic patch prediction using protein foundation models.Bioinform Adv202439483526PubTator, text miningPubMed

1 to 10 of 850

See all 850 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/100506742

GET https://conductscience.org/api/genes/v1/100506742/trials