Gene · 100506742
CASP12: caspase 12 (gene/pseudogene)
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CASP12: caspase 12 (gene/pseudogene). Genes, record 100506742. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/100506742
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q6UXS9 | Inactive caspase-12 | 341 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents4
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
Drugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| EMRICASAN | CHEMBL197672 | Caspase inhibitor | INHIBITOR |
Source ChEMBL
Trials11
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT04803227 | EMRICASAN | PHASE1 | ClinicalTrials.gov | |
| NCT03205345 | EMRICASAN | PHASE2 | ClinicalTrials.gov | |
| NCT02686762 | EMRICASAN | PHASE2 | ClinicalTrials.gov | |
| NCT02230683 | EMRICASAN | PHASE2 | 2016-12-21 | ClinicalTrials.gov |
| NCT02230670 | EMRICASAN | PHASE2 | 2017-07-05 | ClinicalTrials.gov |
| NCT02138253 | EMRICASAN | PHASE2 | 2019-12-11 | ClinicalTrials.gov |
| NCT02077374 | EMRICASAN | PHASE2 | 2016-07-21 | ClinicalTrials.gov |
| NCT01937130 | EMRICASAN | PHASE2 | 2016-04-11 | ClinicalTrials.gov |
| NCT01912404 | EMRICASAN | PHASE2 | 2016-11-04 | ClinicalTrials.gov |
| NCT01653899 | EMRICASAN | PHASE1/PHASE2 | ClinicalTrials.gov |
1 to 10 of 11
See all 11 trialsNIH grants377
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CASP12 papers | Newest fiscal year |
|---|---|---|---|
| R01GM100482 | Center for Critical Assessment of Structure Prediction (CASP) | 22 | 2025 |
| P01AG005842 | Understanding and Improving Healthcare Decision-Making and Outcomes for People Living with Alzheimer's Disease and Related Dementias | 15 | 2025 |
| R01AI134678 | Structure-based functional annotation of microbial genomes | 10 | 2025 |
| U01AG009740 | Health and Retirement Study: Yrs 35-40 | 9 | 2025 |
| R35GM118078 | Analysis and Prediction of Molecular Interactions | 4 | 2025 |
| R35GM126948 | Modeling and dynamics of biomolecules on cellular scales | 3 | 2025 |
| P01CA092584 | Structural Cell Biology of DNA Repair Machines | 2 | 2025 |
| P30ES005022 | Rutgers Center for Environmental Exposure and Disease (CEED) | 2 | 2025 |
| P30ES017885 | Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD) | 2 | 2025 |
| P30GM124169 | ALS Efficiently Networking Advanced Beam Line Experiments (ALS-ENABLE) | 2 | 2025 |
1 to 10 of 377Source NIH's project files
See all 377 nih grantsPapers850
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Association between psychological wellbeing and the COVID-19-related outcomes in Europeans aged ≥ 50 years old: The SHARE study. | Hum Vaccin Immunother | 2026 | 42610257 | PubTator, text mining | PubMed |
| Prognostic Value of Endoplasmic Reticulum Stress-Related Gene Signature in Thyroid Cancer. | Curr Med Sci | 2026 | 42406224 | PubTator, text mining | PubMed |
| Associations between handgrip strength, motor tasks, and quality of life in older adults with osteoarthritis. | Eur J Appl Physiol | 2026 | 41351757 | PubTator, text mining | PubMed |
| Pathway-guided architectures for interpretable AI in biological research. | Comput Struct Biotechnol J | 2025 | 41282420 | PubTator, text mining | PubMed |
| Culturally appropriate physical activity promotion strategy package among older Chinese adults in the UK: a feasibility randomised control trial protocol. | Pilot Feasibility Stud | 2025 | 41194268 | PubTator, text mining | PubMed |
| Stable Marital Histories Predict Happiness and Health Across Educational Groups. | Eur J Popul | 2025 | 40358790 | PubTator, text mining | PubMed |
| The Historical Evolution and Significance of Multiple Sequence Alignment in Molecular Structure and Function Prediction. | Biomolecules | 2024 | 39766238 | PubTator, text mining | PubMed |
| Bilingual language model for protein sequence and structure. | NAR Genom Bioinform | 2024 | 39633723 | PubTator, text mining | PubMed |
| DCMA: faster protein backbone dihedral angle prediction using a dilated convolutional attention-based neural network. | Front Bioinform | 2024 | 39493577 | PubTator, text mining | PubMed |
| PatchProt: hydrophobic patch prediction using protein foundation models. | Bioinform Adv | 2024 | 39483526 | PubTator, text mining | PubMed |
1 to 10 of 850
See all 850 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/100506742
GET https://conductscience.org/api/genes/v1/100506742/trials