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Gene · 10062

NR1H3: nuclear receptor subfamily 1 group H member 3

11 sourcesgene-search-2026-11-11-0.1.0

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ConductScience Library. NR1H3: nuclear receptor subfamily 1 group H member 3. Genes, record 10062. Release gene-search-2026-11-11-0.1.0, 11 Nov 2026. https://conductscience.org/library/genes/10062

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Gene

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

Symbol
NR1H3
HGNC
Name
nuclear receptor subfamily 1 group H member 3
HGNC
NCBI Gene ID
10062
NCBI Gene
HGNC ID
HGNC:7966
HGNC
Ensembl
ENSG00000025434
NCBI Gene
Aliases
LXR-a, LXRA, LXRa, RLD-1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13133Oxysterols receptor LXR-alpha4477Ensembl, GeneID, HGNC

Source UniProt

Patents46

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026062949 A2026-04-1022Q13133Espacenet
US 12502368 B22025-12-2322Q13133Espacenet
EP 4641201 A22025-10-2913239Q13133Espacenet
JP 2025147176 A2025-10-0615418Q13133Espacenet
JP 2025517969 A2025-06-1213239Q13133Espacenet
JP 2025028160 A2025-02-2815418Q13133Espacenet
JP 2025024198 A2025-02-1914139Q13133Espacenet
JP 2025024198 A2025-02-1914143Q13133Espacenet
KR 1020250010750 A2025-01-2115418Q13133Espacenet
JP 2024109657 A2024-08-1415257Q13133Espacenet

1 to 10 of 46

See all 46 patents

Drugs6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABEQUOLIXRONCHEMBL573677Liver X receptor agonistAGONISTChEMBL
BMS-852927CHEMBL3945199LXR-alpha modulatorMODULATORChEMBL
CS-8080CHEMBL3545238LXR-alpha agonistAGONISTChEMBL
HYODEOXYCHOLIC_ACIDCHEMBL272621LXR-alpha agonistAGONISTChEMBL
LXR-623CHEMBL456237LXR-alpha agonistAGONISTChEMBL
ROVAZOLACCHEMBL4297218Liver X receptor agonistAGONISTChEMBL

Trials6

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05911308ABEQUOLIXRONPHASE1ClinicalTrials.gov
NCT03859986ROVAZOLACPHASE2ClinicalTrials.gov
NCT03175354ROVAZOLACPHASE2ClinicalTrials.gov
NCT02922764ABEQUOLIXRONPHASE1ClinicalTrials.gov
NCT01931241HYODEOXYCHOLIC_ACIDPHASE1ClinicalTrials.gov
NCT01651273BMS-852927PHASE1ClinicalTrials.gov

NIH grants1,976

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal year
P30DK063491Diabetes Research Center (DRC)152025
P30EY005722Center Core Grant for Vision Research72025
P30DK020572Michigan Diabetes Research Center (MDRC)62025
P30CA016087Cancer Center Support Grant52025
P30DK040561Boston Area Nutrition Obesity Research Center (NORC)52025
R01DK091183Transcriptional co-regulators and macrophage gene expression52025
ZIAES101586Nuclear receptors: action, functions, and roles in disease52025
P30CA013148Comprehensive Cancer Center Support Grant42025
P30DK048520Colorado Nutrition Obesity Research Center42025
R35GM118041Regulation of xenobiotic receptors PXR and CAR, and CYP3A: implications in drug disposition42025

1 to 10 of 1,976Source NIH's project files

See all 1,976 nih grants

Papers4,148

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42745992PubTator, text miningPubMed
42736272PubTator, text miningPubMed
42732035PubTator, text miningPubMed
42721809PubTator, text miningPubMed
42688002PubTator, text miningPubMed
42674150PubTator, text miningPubMed
42639673PubTator, text miningPubMed
42609920PubTator, text miningPubMed
42600325PubTator, text miningPubMed
42592650PubTator, text miningPubMed

1 to 10 of 4,148

See all 4,148 papers

Sources 11

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNone stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GeneNone named. Public domain as US government information
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10062

GET https://conductscience.org/api/genes/v1/10062/patents?page=2