Gene · 10068
IL18BP: interleukin 18 binding protein
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. IL18BP: interleukin 18 binding protein. Genes, record 10068. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10068
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O95998 | Interleukin-18-binding protein | 194 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents159
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4720303 A2 | 2026-04-08 | 2 | O95998 | Espacenet |
| JP 2026042874 A | 2026-03-11 | 254 | O95998 | Espacenet |
| JP 2026000906 A | 2026-01-06 | 266 | O95998 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 1777 | O95998 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 6931 | O95998 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 6932 | O95998 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 6933 | O95998 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 6934 | O95998 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 6935 | O95998 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 6936 | O95998 | Espacenet |
1 to 10 of 159
See all 159 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants828
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | IL18BP papers | Newest fiscal year |
|---|---|---|---|
| R01AI015614 | Pathogenesis of Fever in Man | 34 | 2025 |
| UL1TR001866 | Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success | 8 | 2025 |
| R01HL070241 | Insulin-Like Growth Factor-1 and Atherosclerosis | 7 | 2025 |
| P30CA046934 | University of Colorado Cancer Center Support Grant | 6 | 2025 |
| R01AI127564 | Genome-wide search for inborn errors of IL-17 immunity underlying chronic mucocutaneous candidiasis | 5 | 2025 |
| T32AR076951 | Training Program/Rheumatic Diseases | 5 | 2025 |
| U19AI082630 | Durable Alteration of the Human Immune system after Infection or Immunotherapy | 5 | 2025 |
| ZIAAI001220 | Pathogenesis, and Outcome of Autoinflammatory Diseases, NOMID/CAPS, DIRA, CANDLE, SAVI, NLRC4-MAS, Still's-like Diseases, and other Undifferentiated Autoinflammatory Diseases | 4 | 2025 |
| ZIAHD002400 | The Role Of Subclinical Infection And Cytokines In Preterm Parturition | 4 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 3 | 2025 |
1 to 10 of 828Source NIH's project files
See all 828 nih grantsPapers1,302
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Effects of Pulsatile and Non-Pulsatile Cardiopulmonary Bypass on Early Inflammatory Response After Cardiac Surgery: A Secondary Biomarker Analysis of a Multicentric Randomized Controlled Trial. | J Clin Med | 2026 | 42795998 | PubTator, text mining | PubMed |
Pain and Analgesic Doses Versus Free Interleukin 18 (IL-18F) Blood Levels Following Surgery: A Prospective Randomized Study of Patients With Minilaparotomy Cholecystectomy Versus Laparoscopic Cholecystectomy. | In Vivo | 2026 | 42665372 | PubTator, text mining | PubMed |
| Genetic and autoimmune predispositions to fulminant viral hepatitis in children. | Front Immunol | 2026 | 42630887 | PubTator, text mining | PubMed |
| Interleukin-18 armours antitumour immune effectors. | Nat Rev Immunol | 2026 | 42463973 | PubTator, text mining | PubMed |
| Anti-PD1-IL18 immunoconjugate promotes effector T cell-mediated antitumor immunity. | J Immunother Cancer | 2026 | 42448430 | PubTator, text mining | PubMed |
| Biochemical and cytokine profiles in COVID-19 patients from northeastern Brazil: IL-18BPa as a predictive marker and IL-37 associated with disease severity. | Hum Immunol | 2026 | 42435515 | PubTator, text mining | PubMed |
| Adenosine Pathway-Based Prognostic Signature for Predicting Clinical Outcomes and Immune Microenvironment Characteristics in Epithelial Ovarian Cancer. | J Clin Pract Res | 2026 | 42416131 | PubTator, text mining | PubMed |
| Cross-Platform Gene Signature to Predict Survival Outcomes for Nasopharyngeal Carcinoma. | JCO Precis Oncol | 2026 | 42385107 | PubTator, text mining | PubMed |
| IL-18 and MIG increase one year after transition to dolutegravir-based dual therapy despite sustained viral suppression. | Front Immunol | 2026 | 42292407 | PubTator, text mining | PubMed |
| Establishment and validation of a prognostic model for pancreatic cancer utilizing genes of tumor-associated neutrophils. | Discov Oncol | 2026 | 42286393 | PubTator, text mining | PubMed |
1 to 10 of 1,302
See all 1,302 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/10068
GET https://conductscience.org/api/genes/v1/10068/patents?page=2