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Gene · 10068

IL18BP: interleukin 18 binding protein

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IL18BP: interleukin 18 binding protein. Genes, record 10068. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10068

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Gene

Symbol
IL18BP
HGNC
Name
interleukin 18 binding protein
HGNC
NCBI Gene ID
10068
NCBI Gene
HGNC ID
HGNC:5987
HGNC
Ensembl
ENSG00000137496
NCBI Gene
Aliases
FVH, IL18BPa
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O95998Interleukin-18-binding protein1941Ensembl, GeneID, HGNC

Source UniProt

Patents159

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4720303 A22026-04-082O95998Espacenet
JP 2026042874 A2026-03-11254O95998Espacenet
JP 2026000906 A2026-01-06266O95998Espacenet
EP 4650780 A22025-11-191777O95998Espacenet
JP 2025147176 A2025-10-066931O95998Espacenet
JP 2025147176 A2025-10-066932O95998Espacenet
JP 2025147176 A2025-10-066933O95998Espacenet
JP 2025147176 A2025-10-066934O95998Espacenet
JP 2025147176 A2025-10-066935O95998Espacenet
JP 2025147176 A2025-10-066936O95998Espacenet

1 to 10 of 159

See all 159 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants828

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIL18BP papersNewest fiscal year
R01AI015614Pathogenesis of Fever in Man342025
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success82025
R01HL070241Insulin-Like Growth Factor-1 and Atherosclerosis72025
P30CA046934University of Colorado Cancer Center Support Grant62025
R01AI127564Genome-wide search for inborn errors of IL-17 immunity underlying chronic mucocutaneous candidiasis52025
T32AR076951Training Program/Rheumatic Diseases52025
U19AI082630Durable Alteration of the Human Immune system after Infection or Immunotherapy52025
ZIAAI001220Pathogenesis, and Outcome of Autoinflammatory Diseases, NOMID/CAPS, DIRA, CANDLE, SAVI, NLRC4-MAS, Still's-like Diseases, and other Undifferentiated Autoinflammatory Diseases42025
ZIAHD002400The Role Of Subclinical Infection And Cytokines In Preterm Parturition42025
P30CA006973Regional Oncology Research Center32025

1 to 10 of 828Source NIH's project files

See all 828 nih grants

Papers1,302

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Effects of Pulsatile and Non-Pulsatile Cardiopulmonary Bypass on Early Inflammatory Response After Cardiac Surgery: A Secondary Biomarker Analysis of a Multicentric Randomized Controlled Trial.J Clin Med202642795998PubTator, text miningPubMed
Pain and Analgesic Doses Versus Free Interleukin 18 (IL-18F) Blood Levels Following Surgery: A Prospective Randomized Study of Patients With Minilaparotomy Cholecystectomy Versus Laparoscopic Cholecystectomy.
In Vivo202642665372PubTator, text miningPubMed
Genetic and autoimmune predispositions to fulminant viral hepatitis in children.Front Immunol202642630887PubTator, text miningPubMed
Interleukin-18 armours antitumour immune effectors.Nat Rev Immunol202642463973PubTator, text miningPubMed
Anti-PD1-IL18 immunoconjugate promotes effector T cell-mediated antitumor immunity.J Immunother Cancer202642448430PubTator, text miningPubMed
Biochemical and cytokine profiles in COVID-19 patients from northeastern Brazil: IL-18BPa as a predictive marker and IL-37 associated with disease severity.Hum Immunol202642435515PubTator, text miningPubMed
Adenosine Pathway-Based Prognostic Signature for Predicting Clinical Outcomes and Immune Microenvironment Characteristics in Epithelial Ovarian Cancer.J Clin Pract Res202642416131PubTator, text miningPubMed
Cross-Platform Gene Signature to Predict Survival Outcomes for Nasopharyngeal Carcinoma.JCO Precis Oncol202642385107PubTator, text miningPubMed
IL-18 and MIG increase one year after transition to dolutegravir-based dual therapy despite sustained viral suppression.Front Immunol202642292407PubTator, text miningPubMed
Establishment and validation of a prognostic model for pancreatic cancer utilizing genes of tumor-associated neutrophils.Discov Oncol202642286393PubTator, text miningPubMed

1 to 10 of 1,302

See all 1,302 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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