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Gene · 10076

PTPRU: protein tyrosine phosphatase receptor type U

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PTPRU: protein tyrosine phosphatase receptor type U. Genes, record 10076. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10076

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Gene

Symbol
PTPRU
HGNC
Name
protein tyrosine phosphatase receptor type U
HGNC
NCBI Gene ID
10076
NCBI Gene
HGNC ID
HGNC:9683
HGNC
Ensembl
ENSG00000060656
NCBI Gene
Aliases
FMI, PCP-2, PTP, PTP-J, PTP-PI, PTP-RO, PTPPSI, PTPRO, PTPU2, R-PTP-PSI, R-PTP-U, hPTP-J
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q92729Receptor-type tyrosine-protein phosphatase U1,4462Ensembl, GeneID, HGNC

Source UniProt

Patents16

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1460196Q92729Espacenet
EP 4650780 A22025-11-196130Q92729Espacenet
EP 4641201 A22025-10-295879Q92729Espacenet
JP 2025529142 A2025-09-043651Q92729Espacenet
US 12371689 B22025-07-293651Q92729Espacenet
JP 2025517969 A2025-06-125879Q92729Espacenet
JP 2025517970 A2025-06-126130Q92729Espacenet
US 11446398 B22022-09-2069484Q92729Espacenet
US 11400116 B22022-08-023348Q92729Espacenet
JP 2022524081 A2022-04-27172455Q92729Espacenet

1 to 10 of 16

See all 16 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,790

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePTPRU papersNewest fiscal year
R01CA069202Structure/Function of Protein Tyrosine Phosphatases332025
R01CA053840Protein Tyrosine Dephosphorylation & Signal Transduction202025
P30CA045508CSHL Cancer Center Support Grant142025
P30CA030199Cancer Center Support Grant (CCSG)102025
P30CA016672Cancer Center Support Grant82025
P30CA023168Cancer Center Support Grant72025
R01GM102187Chemical Tools for Probing Cysteine Sulfenation and Sulfination Redox Biology72025
P30CA006927Comprehensive Cancer Center Program at Fox Chase62025
P30CA013330Cancer Center Support Grant52025
P30CA036727Buffett Cancer Center Support Grant52025

1 to 10 of 1,790Source NIH's project files

See all 1,790 nih grants

Papers2,589

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The protein tyrosine phosphatase interactome: beyond catalytic activity.Trends Biochem Sci202642823268PubTator, text miningPubMed
Identification and Expression Analysis of the Formin Gene Family in Neopyropia yezoensis Under Different Environmental Conditions.Genes (Basel)202642792983PubTator, text miningPubMed
Deciphering SHP-2 conformational switching via elastic network models and transfer entropy analysis.J Mol Model202642742803PubTator, text miningPubMed
The role of classical protein tyrosine phosphatases in diabetic kidney disease and therapeutic implications.J Biomed Sci202642687181PubTator, text miningPubMed
Distinct Conformational Switches Control WPD-Loop Dynamics Across Protein Tyrosine Phosphatase Subfamilies.Proteins202642665911PubTator, text miningPubMed
Design, synthesis, and biological evaluation of novel furo[3,2-b]pyrrole-benzimidazole series as potential protein tyrosine phosphatase (PTPs) inhibitors.Bioorg Chem202642612262PubTator, text miningPubMed
Yorkie/YAP Interactors: Fine-Tuning the Hippo Pathway Output.Cold Spring Harb Perspect Biol202642575696PubTator, text miningPubMed
Targeting CD148 for Antithrombotic Therapy: Functional and Molecular Evaluation of AKB-9778.Pharmacol Res Perspect202642538585PubTator, text miningPubMed
Decoding SHP2 mutations by computational saturation mutagenesis.J Mol Cell Biol202642466850PubTator, text miningPubMed
Multicomponent reactions for protein tyrosine phosphatase inhibitors.Mol Divers202642423920PubTator, text miningPubMed

1 to 10 of 2,589

See all 2,589 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10076

GET https://conductscience.org/api/genes/v1/10076/patents