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Gene · 10105

PPIF: peptidylprolyl isomerase F

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PPIF: peptidylprolyl isomerase F. Genes, record 10105. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10105

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Gene

Symbol
PPIF
HGNC
Name
peptidylprolyl isomerase F
HGNC
NCBI Gene ID
10105
NCBI Gene
HGNC ID
HGNC:9259
HGNC
Ensembl
ENSG00000108179
NCBI Gene
Aliases
CYP3, CyP-M, Cyp-D, CypD, hCyP3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P30405Peptidyl-prolyl cis-trans isomerase F, mitochondrial20772Ensembl, GeneID, HGNC

Source UniProt

Patents87

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1457317P30405Espacenet
EP 4650780 A22025-11-19619P30405Espacenet
EP 4641202 A22025-10-294351P30405Espacenet
JP 2025517970 A2025-06-12619P30405Espacenet
KR 1020250017231 A2025-02-044351P30405Espacenet
US 12006548 B22024-06-11436P30405Espacenet
JP 2022550670 A2022-12-0588P30405Espacenet
US 11446398 B22022-09-2061891P30405Espacenet
JP 2022524081 A2022-04-27164862P30405Espacenet
US 11078247 B22021-08-038801P30405Espacenet

1 to 10 of 87

See all 87 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,655

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePPIF papersNewest fiscal year
P50AA011999Southern California Research Center for ALPD and Cirrhosis92025
U54DK106846Hematopoietic stem and progenitor cell regulation for enhanced clinical efficacy82025
ZIAHL002066Mechanisms of cardiac ischemia-reperfusion injury and cardioprotection82025
P30CA010815Consolidated Basic Cancer Research Program62025
R01HL122124Mitochondria-SR Tethering: Its Role in Cardiac Bioenergetics and Ca2+ Dynamics52025
R01HL071158Acid, Succinate and Glyoxal Metabolism in Ischemia42025
R37NS045876Mitochondrial Ion Channels in Hypoxic Neurons42025
P30AR069655Rochester Resource-Based Center for Bone, Muscle and Orthopaedic Research (ROCSTARR) (Overall Application)32025
P30CA008748Cancer Center Support Grant32025
P30CA016672Cancer Center Support Grant32025

1 to 10 of 1,655Source NIH's project files

See all 1,655 nih grants

Papers2,346

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
RETRACTION: Inhibitory Effect of Melatonin on Necroptosis via Repressing the Ripk3-PGAM5-CypD-mPTP Pathway Attenuates Cardiac Microvascular Ischemia-Reperfusion Injury.J Pineal Res202642763414PubTator, text miningPubMed
SPG7-Mediated Regulation of mPTP and Mitochondrial Flickering in COPD: A Bioinformatics-Based Prediction of Mechanistic Framework.Int J Chron Obstruct Pulmon Dis202642404999PubTator, text miningPubMed
Lactate-Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo-Immunotherapy by Suppressing Tumor PANoptosis.Adv Sci (Weinh)202642378634PubTator, text miningPubMed
CYP3A4, CYP3A5, and CYP4F2 Polymorphisms and Bleeding Risk in Ticagrelor-Based Dual Antiplatelet Therapy.Medicina (Kaunas)202642356213PubTator, text miningPubMed
Platelet-Related Gene Signature Predicts Prognosis, Immune Landscape, and Drug Sensitivity in Acute Myeloid Leukemia.Biofactors202642340073PubTator, text miningPubMed
LmCYP3136A1: A cysteine-deficient P450 with dual roles in specific insecticide detoxification and olfaction in Locusta migratoria.Pestic Biochem Physiol202642264727PubTator, text miningPubMed
Yiqi Huoxue formula promotes post-myocardial infarction angiogenesis by modulating mitochondria-associated membranes (MAMs) and calcium homeostasis via the cGMP/PKG signaling pathway.J Ethnopharmacol202642248375PubTator, text miningPubMed
Identification and experimental validation of mitochondria pathway related genes in acute myeloid leukemia.Front Immunol202642238582PubTator, text miningPubMed
Low-abundance plasma proteomics reveals NET-associated molecular signatures in rheumatoid arthritis.Immunobiology202642139762PubTator, text miningPubMed
Alkalization of the intracellular pH reprograms TNF-α signaling from inflammatory NF-κB activation to tumoricidal RIP kinase-dependent necroptosis in cancer cells.Acta Pharmacol Sin202641951772PubTator, text miningPubMed

1 to 10 of 2,346

See all 2,346 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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