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Gene · 10114

HIPK3: homeodomain interacting protein kinase 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HIPK3: homeodomain interacting protein kinase 3. Genes, record 10114. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10114

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Gene

Symbol
HIPK3
HGNC
Name
homeodomain interacting protein kinase 3
HGNC
NCBI Gene ID
10114
NCBI Gene
HGNC ID
HGNC:4915
HGNC
Ensembl
ENSG00000110422
NCBI Gene
Aliases
DYRK6, FIST3, PKY, YAK1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9H422Homeodomain-interacting protein kinase 31,2152Ensembl, GeneID, HGNC

Source UniProt

Patents13

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1449347Q9H422Espacenet
EP 4650780 A22025-11-194256Q9H422Espacenet
EP 4641201 A22025-10-293818Q9H422Espacenet
JP 2025529142 A2025-09-041955Q9H422Espacenet
US 12371689 B22025-07-291955Q9H422Espacenet
JP 2025517969 A2025-06-123818Q9H422Espacenet
JP 2025517970 A2025-06-124256Q9H422Espacenet
US 11446398 B22022-09-2038887Q9H422Espacenet
JP 2022524081 A2022-04-27141858Q9H422Espacenet
JP 2019054813 A2019-04-11229782Q9H422Espacenet

1 to 10 of 13

See all 13 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants441

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHIPK3 papersNewest fiscal year
ZIAAG000511Post-transcriptional control of Proliferation, Stress Response & Carcinogenesis42025
P30CA016672Cancer Center Support Grant32025
P30CA068485Cancer Center Support Grant22025
P30CA142543UT Southwestern Medical Center Simmons Comprehensive Cancer Center22025
P50CA196530Yale SPORE in Lung Cancer (YSILC): The Biology and Personalized Treatment of Lung Cancer22025
R01AI127375Systematic Analysis of Morphogenesis, Commensalism, and Virulence in a Leading Human Fungal Pathogen22025
R01HL089221Determinants of AAV Tropism22025
R35GM119735Regulatory roles for the Integrator complex and circular RNAs22025
I01BX000332Posttranscriptional Control of Gut Mucosal Defense and Homeostasis12025
IK6BX004213BLRD Research Career Scientist Award Application12025

1 to 10 of 441Source NIH's project files

See all 441 nih grants

Papers1,341

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
CircHIPK3 promotes the progression of B-cell acute lymphoblastic leukemia in children by binding to STAT3.Front Pharmacol202642824327PubTator, text miningPubMed
PBMC circRNA Profiles Distinguish Atypical From Idiopathic Parkinsonism and Track Clinical Severity Across Syndromes.J Neurochem202642415371PubTator, text miningPubMed
HIPK3 silencing promotes M2 macrophage polarization through NF-κB signaling pathway to enhance oral cancer progression.Mol Genet Genomics202642371219PubTator, text miningPubMed
Research progress of plant-derived chemical compounds for overcoming pancreatic cancer drug resistance.World J Gastroenterol202641810441PubTator, text miningPubMed
Circular RNAs: Key Regulators of Tumor Metabolic Reprogramming and Clinical Translation.Oncol Res202641799520PubTator, text miningPubMed
Divergent roles of circMPP6 and its parental gene MPP6 in non-small cell lung cancer.Front Cell Dev Biol202641799439PubTator, text miningPubMed
Blood-based epigenetic biomarkers in rheumatoid arthritis: current knowledge and future perspectives.Front Immunol202641798917PubTator, text miningPubMed
TUBB2A and TM4SF1 Methylation Define Prognostic Subgroups in Adult-Type Diffuse Glioma.Cancers (Basel)202641749891PubTator, text miningPubMed
Chinese Herbal Medicines for Diabetic Cardio-Cerebrovascular Diseases: Key Bioactive Metabolites and Action Mechanisms.J Nutr Metab202641743998PubTator, text miningPubMed
Comparison of CRISPR Sequences in Archaea and Bacteria with Eukaryotic microRNAs.Avicenna J Med Biotechnol202541727334PubTator, text miningPubMed

1 to 10 of 1,341

See all 1,341 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10114

GET https://conductscience.org/api/genes/v1/10114/patents