Gene · 10128
LRPPRC: leucine rich pentatricopeptide repeat containing
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. LRPPRC: leucine rich pentatricopeptide repeat containing. Genes, record 10128. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10128
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P42704 | Leucine-rich PPR motif-containing protein, mitochondrial | 1,394 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents33
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026108757 A | 2026-06-30 | 5 | P42704 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 51373 | P42704 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 1817 | P42704 | Espacenet |
| US 12351611 B2 | 2025-07-08 | 5 | P42704 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 1817 | P42704 | Espacenet |
| US 12091437 B2 | 2024-09-17 | 5 | P42704 | Espacenet |
| US 11891420 B2 | 2024-02-06 | 5 | P42704 | Espacenet |
| JP 2023518996 A | 2023-05-09 | 15 | P42704 | Espacenet |
| KR 1020220158065 A | 2022-11-29 | 5 | P42704 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 45887 | P42704 | Espacenet |
1 to 10 of 33
See all 33 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants769
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | LRPPRC papers | Newest fiscal year |
|---|---|---|---|
| R01CA080728 | Oncogenic Impact of eIF4E-dependent RNA Export in Cancer | 12 | 2025 |
| R01CA098571 | Molecular Mechanisms of eIF4E Mediated Transformation | 11 | 2025 |
| R35GM118141 | Mitochondrial Biogenesis in Health and Disease | 7 | 2025 |
| F30HD107939 | Mitochondrial mRNA structure as a driver of Leigh Syndrome | 4 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 4 | 2025 |
| R01AG011085 | Ubiquitin‐mediated proteolysis and cell cycle control | 3 | 2025 |
| R01HL107304 | Epicardial remodeling in cardiomyopathy and cardiac aging | 3 | 2025 |
| T32GM007748 | Training Grant in Genetics | 3 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 2 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 2 | 2025 |
1 to 10 of 769Source NIH's project files
See all 769 nih grantsPapers1,499
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| SLIRP differentially modulates RNA binding of pathogenic LRPPRC variants. | NAR Mol Med | 2026 | 42688402 | PubTator, text mining | PubMed |
| Mechanism of troxerutin-mediated regulation of EGLN3/LRPPRC in B[a]P-induced lung adenocarcinoma. | Int Immunopharmacol | 2026 | 42556279 | PubTator, text mining | PubMed |
| Correction: Bendless is essential for PINK1-Park mediated Mitofusin degradation under mitochondrial stress caused by loss of LRPPRC. | PLoS Genet | 2026 | 42555611 | PubTator, text mining | PubMed |
| LRPPRC deficiency impairs trophoblast function through disrupted phosphatidylinositol metabolism in recurrent pregnancy loss. | Hum Reprod | 2026 | 42515815 | PubTator, text mining | PubMed |
| Reduced LANCL1-AS1 in old human skeletal muscle diminishes mitochondrial activity, shortens mt-mRNA poly(A) tails, and suppresses myogenesis. | bioRxiv | 2026 | 42465395 | PubTator, text mining | PubMed |
| Comprehensive Analysis of Disulfidptosis-Related Genes in Multiple Myeloma: Implications for Prognosis and Immune Microenvironment. | Acta Haematol | 2026 | 42461871 | PubTator, text mining | PubMed |
| Discovery of Novel LRPPRC Inhibitors Featuring a Biphenyl-Acylhydrazone Scaffold with Potent Broad-Spectrum Antitumor Activity. | J Med Chem | 2026 | 42441917 | PubTator, text mining | PubMed |
| Identifying potential drug targets for physical and cognitive frailty: an integrative analysis of CHARLS cohort, mendelian randomization, and gene colocalization. | Biogerontology | 2026 | 42337223 | PubTator, text mining | PubMed |
| Folding the message: mRNA structure as a regulatory layer of human mitochondrial gene expression. | Biochim Biophys Acta Mol Cell Res | 2026 | 42263953 | PubTator, text mining | PubMed |
Construction of an eight-disulfidptosis-related long non-coding RNA prognostic signature and mechanistic investigation of key molecule MKLN1-AS driving hepatocellular carcinoma progression via the miR-139-5p/LRPPRC axis. | Discov Oncol | 2026 | 42243619 | PubTator, text mining | PubMed |
1 to 10 of 1,499
See all 1,499 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/10128
GET https://conductscience.org/api/genes/v1/10128/patents?page=2