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Gene · 10128

LRPPRC: leucine rich pentatricopeptide repeat containing

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. LRPPRC: leucine rich pentatricopeptide repeat containing. Genes, record 10128. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10128

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Gene

Symbol
LRPPRC
HGNC
Name
leucine rich pentatricopeptide repeat containing
HGNC
NCBI Gene ID
10128
NCBI Gene
HGNC ID
HGNC:15714
HGNC
Ensembl
ENSG00000138095
NCBI Gene
Aliases
CLONE-23970, GP130, LRP130, LSFC, MC4DN5
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P42704Leucine-rich PPR motif-containing protein, mitochondrial1,3942Ensembl, GeneID, HGNC

Source UniProt

Patents33

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026108757 A2026-06-305P42704Espacenet
JP 2026004568 A2026-01-1451373P42704Espacenet
EP 4650780 A22025-11-191817P42704Espacenet
US 12351611 B22025-07-085P42704Espacenet
JP 2025517970 A2025-06-121817P42704Espacenet
US 12091437 B22024-09-175P42704Espacenet
US 11891420 B22024-02-065P42704Espacenet
JP 2023518996 A2023-05-0915P42704Espacenet
KR 1020220158065 A2022-11-295P42704Espacenet
US 11446398 B22022-09-2045887P42704Espacenet

1 to 10 of 33

See all 33 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants769

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleLRPPRC papersNewest fiscal year
R01CA080728Oncogenic Impact of eIF4E-dependent RNA Export in Cancer122025
R01CA098571Molecular Mechanisms of eIF4E Mediated Transformation112025
R35GM118141Mitochondrial Biogenesis in Health and Disease72025
F30HD107939Mitochondrial mRNA structure as a driver of Leigh Syndrome42025
P30CA008748Cancer Center Support Grant42025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control32025
R01HL107304Epicardial remodeling in cardiomyopathy and cardiac aging32025
T32GM007748Training Grant in Genetics32025
P30CA016086Cancer Center Support Grant22025
P30CA016672Cancer Center Support Grant22025

1 to 10 of 769Source NIH's project files

See all 769 nih grants

Papers1,499

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
SLIRP differentially modulates RNA binding of pathogenic LRPPRC variants.NAR Mol Med202642688402PubTator, text miningPubMed
Mechanism of troxerutin-mediated regulation of EGLN3/LRPPRC in B[a]P-induced lung adenocarcinoma.Int Immunopharmacol202642556279PubTator, text miningPubMed
Correction: Bendless is essential for PINK1-Park mediated Mitofusin degradation under mitochondrial stress caused by loss of LRPPRC.PLoS Genet202642555611PubTator, text miningPubMed
LRPPRC deficiency impairs trophoblast function through disrupted phosphatidylinositol metabolism in recurrent pregnancy loss.Hum Reprod202642515815PubTator, text miningPubMed
Reduced LANCL1-AS1 in old human skeletal muscle diminishes mitochondrial activity, shortens mt-mRNA poly(A) tails, and suppresses myogenesis.bioRxiv202642465395PubTator, text miningPubMed
Comprehensive Analysis of Disulfidptosis-Related Genes in Multiple Myeloma: Implications for Prognosis and Immune Microenvironment.Acta Haematol202642461871PubTator, text miningPubMed
Discovery of Novel LRPPRC Inhibitors Featuring a Biphenyl-Acylhydrazone Scaffold with Potent Broad-Spectrum Antitumor Activity.J Med Chem202642441917PubTator, text miningPubMed
Identifying potential drug targets for physical and cognitive frailty: an integrative analysis of CHARLS cohort, mendelian randomization, and gene colocalization.Biogerontology202642337223PubTator, text miningPubMed
Folding the message: mRNA structure as a regulatory layer of human mitochondrial gene expression.Biochim Biophys Acta Mol Cell Res202642263953PubTator, text miningPubMed
Construction of an eight-disulfidptosis-related long non-coding RNA prognostic signature and mechanistic investigation of key molecule MKLN1-AS driving hepatocellular carcinoma progression via the miR-139-5p/LRPPRC axis.
Discov Oncol202642243619PubTator, text miningPubMed

1 to 10 of 1,499

See all 1,499 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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