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Gene · 10131

TRAP1: TNF receptor associated protein 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TRAP1: TNF receptor associated protein 1. Genes, record 10131. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10131

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Gene

Symbol
TRAP1
HGNC
Name
TNF receptor associated protein 1
HGNC
NCBI Gene ID
10131
NCBI Gene
HGNC ID
HGNC:16264
HGNC
Ensembl
ENSG00000126602
NCBI Gene
Aliases
HSP 75, HSP75, HSP90L, TRAP-1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q12931Heat shock protein 75 kDa, mitochondrial70424Ensembl, GeneID, HGNC

Source UniProt

Patents60

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1467195Q12931Espacenet
EP 4650780 A22025-11-191210Q12931Espacenet
EP 4641201 A22025-10-29859Q12931Espacenet
EP 4641202 A22025-10-294431Q12931Espacenet
EP 4582098 A22025-07-091369Q12931Espacenet
JP 2025517969 A2025-06-12859Q12931Espacenet
JP 2025517970 A2025-06-121210Q12931Espacenet
KR 1020250017231 A2025-02-044431Q12931Espacenet
JP 2024112982 A2024-08-214513Q12931Espacenet
US 11694765 B22023-07-04154Q12931Espacenet

1 to 10 of 60

See all 60 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,180

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTRAP1 papersNewest fiscal year
P30CA010815Consolidated Basic Cancer Research Program172025
ZIASC010074HSP90 and HSP70 Chaperone Proteins and Interactors in Cellular Signal Transduction142025
P30CA008748Cancer Center Support Grant132025
P30CA016672Cancer Center Support Grant62025
ZIABC011032Post-translational modifications of Hsp9062025
R50CA211199Integrative Approach to Comprehensive Analysis of High Throughput Data on a Cancer Center Level42025
P30CA013696Cancer Center Support Grant32025
P30CA014051Cancer Center Support (Core) Grant32025
R01EY021205Characterization of purified myocilin: glaucoma as a protein misfolding disease32025
R35GM139584Regulatory mechanisms of the Hsp90 chaperone machinery32025

1 to 10 of 1,180Source NIH's project files

See all 1,180 nih grants

Papers1,889

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Coordinated regulation of the metaboproteome by Hsp90 chaperones controls metabolic plasticity.iScience202642761197PubTator, text miningPubMed
A poly-L-lysine-functionalized electrochemical immunosensor enables highly sensitive detection of tumor necrosis factor receptor-associated protein 1.Turk J Chem202642683372PubTator, text miningPubMed
The pro-tumorigenic functions of cancer-associated adipocytes are dependent on the mitochondrial chaperone tumor necrosis factor receptor-associated protein 1.Signal Transduct Target Ther202642509229PubTator, text miningPubMed
Isoform-selective HSP90 inhibition as a precision therapeutic strategy for neurodegenerative and metabolic diseases.Prog Neuropsychopharmacol Biol Psychiatry202642508631PubTator, text miningPubMed
HSP90 inhibition partially rescues alternative splicing dysregulation in cell models of myotonic dystrophy.J Biol Chem202642486259PubTator, text miningPubMed
Target deconvolution of a selective HepG2 cytotoxic hit identifies GSTP1 and TRAP1 as candidate molecular targets.RSC Adv202642433452PubTator, text miningPubMed
Plasma proteomics analysis of vitamin C supplementation in people with type 2 diabetes.Nutr Diabetes202642373594PubTator, text miningPubMed
TRAP1 ablation improves mitochondrial cristae and oxidative phosphorylation in pancreatic cancer stem cells.Cancer Drug Resist202642267195PubTator, text miningPubMed
Retraction Note: Knockdown of TRAP1 promotes cisplatin-induced apoptosis by promoting the ROS-dependent mitochondrial dysfunction in lung cancer cells.Mol Cell Biochem202642234383PubTator, text miningPubMed
Prognostic model construction and drug prediction in colorectal cancer using mitochondrial programmed cell death-related genes.Clin Transl Oncol202642184077PubTator, text miningPubMed

1 to 10 of 1,889

See all 1,889 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10131

GET https://conductscience.org/api/genes/v1/10131/patents?page=2